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Category: biotech/medical – Page 267

Physicists demonstrate 3,000 quantum-bit system capable of continuous operation

One often-repeated example illustrates the mind-boggling potential of quantum computing: A machine with 300 quantum bits could simultaneously store more information than the number of particles in the known universe.

Now process this: Harvard scientists just unveiled a system that was 10 times bigger and the first quantum machine able to operate continuously without restarting.

In a paper published in the journal Nature, the team demonstrated a system of more than 3,000 (or qubits) that could run for more than two hours, surmounting a series of technical challenges and representing a significant step toward building the super computers, which could revolutionize science, medicine, finance, and other fields.

This Popular Diet Seems to Reduce Gum Disease, Scientists Say

There’s something rather special about the Mediterranean diet: already associated with a lower risk of Alzheimer’s disease, early death, poor mental health, and more besides, a new study links the diet to better gum health too.

The study, carried out by researchers from King’s College London and the University of Catania in Italy, involved 195 participants with an average age of 49, who were given a health check-up and quizzed on their dietary habits.

Those participants who stuck more closely to the plant-rich Mediterranean diet were less likely to have gum disease, the data showed – especially those who didn’t eat much red meat.

A review of the sufficient conditions for consciousness

In a recently published article, I reviewed over 100 years of neuroscience research to see if some brain regions are more important than others for consciousness. What I found suggests scientists who study consciousness may have been undervaluing the most ancient regions of human brains.

Consciousness is usually defined by neuroscientists as the ability to have subjective experience, such as the experience of tasting an apple or of seeing the redness of its skin.

The leading theories of consciousness suggest that the outer layer of the human brain, called the cortex (in blue in figure 1), is fundamental to consciousness. This is mostly composed of the neocortex, which is newer in our evolutionary history.

The human subcortex (figure 1, brown/beige), underneath the neocortex, has not changed much in the last 500 million years. It is thought to be like electricity for a TV, necessary for consciousness, but not enough on its own.

There is another part of the brain that some neuroscientific theories of consciousness state is irrelevant for consciousness. This is the cerebellum, which is also older than the neocortex and looks like a little brain tucked in the back of the skull (figure 1, purple). Brain activity and brain networks are disrupted in unconsciousness (like in a coma). These changes can be seen in the cortex, subcortex and cerebellum.

As part of my analysis I looked at studies showing what happens to consciousness when brain activity is changed, for example, by applying electrical currents or magnetic pulses to brain regions.

These experiments in humans and animals showed that altering activity in any of these three parts of the brain can alter consciousness. Changing the activity of the neocortex can change your sense of self, make you hallucinate, or affect your judgment.

Continue reading “A review of the sufficient conditions for consciousness” | >

New Huntington’s Disease Therapy Slows Patients’ Disease by 75%

Huntington’s disease is a genetic disorder that is caused by an unusual number of repeats in the huntingtin gene; there make the gene too long, and lead to the production of a toxic protein in brain cells. Symptoms of the disease tend to arise when a person is in their 30s or 40s and it is typically fatal within 20 years. New work may change that, however.

Sugar fingerprints offer faster, more reliable diagnoses for fungal infections

Hospitals worldwide, including Germany, face a growing problem with fungal infections, with an estimated 6 million cases and 3.8 million deaths each year. According to the World Health Organization (WHO), Candida—a common fungus most people encounter at least once in life—is a top concern. While many know it from mild, superficial infections such as thrush, Candida (especially C. auris and C. albicans) can also reach the bloodstream and cause life-threatening disease.

This is increasingly happening in clinics around the world, where Candida finds an ideal target in weakened patients—after major surgery or chemotherapy, for example. Candida can also cling to medical equipment, like catheters, tubes, or prostheses, forming slimy biofilms that are highly resistant to antifungal drugs.

The European Center for Disease Prevention and Control has recently echoed the WHO in sounding the alarm and calling for better prevention, faster diagnosis, and more effective treatment.

Time-released gel packs a one-two punch against aggressive brain tumors

High-grade gliomas are aggressive brain tumors with poor prognosis, largely because even after surgical removal, infiltrative residual tumor cells often regrow during the latency before radiotherapy, leading to recurrence. The standard chemoradiotherapy only modestly improves survival. A crucial window of vulnerability arises post-surgery, before radiotherapy begins, where residual tumor cells are not well addressed by systemic chemotherapy.

Prof. Feng-Huei Lin and Dr. Jason Lin from National Taiwan University have designed a local post-surgical gel packing with sequential delivery of platinum agents that could maintain therapeutic drug concentrations intracranially and synergize with subsequent radiotherapy to eliminate tissue. Their study is published in the Chemical Engineering Journal.

The cutting-edge drug-delivery gel can be directly injected into the surgical cavity following tumor resection. This gel provides sustained local delivery of platinum-based anticancer agents, ensuring effective eradication for residual glioma tissue that remain after surgery. The gel is designed to maximize the therapeutic impact while minimizing systemic exposure.

New Study Finds Evidence of Hepatitis C Virus in Cells Lining Human Brain

Observational studies of psychiatric diseases such as schizophrenia, bipolar disorder and major depression have long tied viral infections with behavioral symptoms in these disorders, but scientists have been unable to find direct evidence of suspected viruses in the brain. Experts say that’s possibly because viruses may not get directly inside the brain, but may target the brain lining instead.

After testing that idea using postmortem human brain samples and the electronic medical records of 285 million patients, a team of Johns Hopkins Medicine scientists says it has found such evidence in the form of the liver-damaging hepatitis C virus in the human brain’s choroid plexus, a collection of cells that make up the lining of the fluid-filled cavities, or ventricles, and — notably — produce the cerebrospinal fluid that protects the brain and spinal cord…

…’Our findings show that it’s possible that some people may be having psychiatric symptoms because they have an infection, and since the hepatitis C infection is treatable, it might be possible for this patient subset to be treated with antiviral drugs and not have to deal with psychiatric symptoms,’ Sabunciyan says.

Growing evidence that the heart has a strong influence on thinking and feeling

The influence of the heart and circulatory system occurs within milliseconds, and every single heartbeat plays a role. The role of the heart in the psyche and cognition is evident in the high coincidence of cardiovascular diseases, such as high blood pressure and heart attack, and mental illnesses, such as depression and anxiety disorders.

There are a number of explanations for this high coincidence, but none of them have been definitively proven yet. For example, negative psychological reactions to a diagnosis of cardiovascular disease are cited as a reason for the development of mental illness. On the other hand, an unhealthy lifestyle in the presence of mental illness is considered a risk factor for the development of cardiovascular disease.

The concept is based on integrated brain–body states. Every , such as a heartbeat or any change in blood pressure or metabolism, is automatically accompanied by a mental or psychological process. This means that the two are inextricably linked.

Chronic Insomnia May Spark Changes in The Brain That Trigger Dementia

Staring at the ceiling while the clock blinks 3am doesn’t only sap energy for the next day. A large, long-running US study of older adults has now linked chronic insomnia to changes inside the brain that set the stage for dementia.

The researchers, from the Mayo Clinic in the US, followed 2,750 people aged 50 and over for an average of five and a half years. Every year the volunteers completed detailed memory tests and many also had brain scans that measured two telltale markers of future cognitive trouble: the buildup of amyloid plaques, and tiny spots of damage in the brain’s white matter – known as white-matter hyperintensities.

Participants were classed as having chronic insomnia if their medical records contained at least two insomnia diagnoses a month apart – a definition that captured 16 percent of the sample.

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