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Category: biotech/medical – Page 2571

An international team of researchers has identified 83 new DNA changes that strongly determine human height as well as also help predict a person’s risk of developing certain growth disorders.

Height is mostly determined by the information encoded in the human DNA — children from tall parents tend to be taller and those from short parents are shorter.

“Of these 83 genetic variations, some influence adult height by more than 2 cm, which is enormous,” said Guillaume Lettre, Professor at Montreal Heart Institute in Canada.

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Bring to life those old biology and museum specimens back to life. Sort of.

Let’s see Ray Kurzweils prediction of bringing people back from the dead may not be that too far off with this recent discovery. BTW — he may be interested in this one.

(Natural News) Rare animals have been sitting in glass jars on museum shelves across the world for decades, but very little is often known about these specimens. And many people would say that is exactly where they belong: on a shelf, as an object of the past simply to be remembered and admired from afar.

However, a recent scientific breakthrough may be able to breathe new life into these long-extinct species. A new technique for extracting DNA has been developed, and it’s something researchers believe could be used to help bring these long-gone animals into the realm of genomic study. (RELATED: Follow more news about scientific breakthroughs at Scientific.news)

Rare animal specimens are kept in liquid-filled jars as a form of preservation. The liquid preservative, such as formalin, often come with consequences, however. As these creatures are left in the liquid, there is a large amount of DNA fragmenting going on — which makes them less than ideal subjects for DNA extraction.

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Can science really enable us stick around on Earth forever? Experts haven’t developed ways to make us invincible, immortal beings who are unsusceptible to physical trauma or starvation. However, studies have been going on to make aging just another preventable disease. Effectively stalling the deterioration of our bodies would then mean humans could live indefinitely.

Peter Diamandis, co-founder of San Diego-based genotype research facility Human Longevity, Inc., spoke at the Singularity University in California last September about challenging aging and the deterioration of the body. The key to unlocking an indefinite lifespan was to improve the repair mechanisms of the body, said Diamandis. His research teams consider the possibility of using stem cells or nanomachines to regenerate our bodies.

Last year, researchers from the Stanford University School of Medicine have used chromosome extensions that dramatically increased the rate of cell division, a growth mechanism of our bodies that weakens over time. The development hints at a chance to turn back the biological clock.

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A year on and we catch up with two kids who were genetically engineered to treat their cancer. This is the future of medicine.

By Michael Le Page.

Two children treated with gene-edited cells to kill their cancers are both doing well more than a year later. The baby girls were both given the experimental treatment only as a last resort, but clinical trials of the therapy are now getting underway in children and adults in the UK.

An 11-month-old girl called Layla was the first to get the treatment, in June 2015. When the team who treated her at Great Ormond Street Hospital in London revealed details in November 2015, they stressed that it was too soon to say if she was cured.

Continue reading “Gene editing has saved the lives of two children with leukaemia” | >

Oh, the logic of objections against rejuvenation! bigsmile

If you’ve ever tried to advocate for rejuvenation, you know it is hard. Usually, people deem the idea as crazy/impossible/dangerous well before you get to finish your first sentence. Living too long would be boring, it would cause overpopulation, ‘immortal’ dictators, and what you have. However, you’ve probably never heard anyone use the same arguments to say that we should not cure individual age-related diseases. This is largely because people have little to no idea about what ageing really is, and how it cannot be untangled from the so-called age-related pathologies. These are nothing more, nothing less, than the result of the life-long accumulation of several types of damage caused by the body’s normal operations. Unlike infectious diseases, the diseases of old age are not the result of a pathogen attack, but essentially of your own body falling apart. As I was saying, people are largely unaware of this fact, and therefore expect that the diseases of ageing could be cured one by one without having to interfere with the ageing process itself, as if the two weren’t related at all. The result of this false expectation would be that you could cure Alzheimer’s, Parkinson’s, etc., but somehow old people would still drop dead around the age of 80 just because they’re old. That’s like saying they died of being healthy.

Back to reality, this can’t be done. To cure the diseases of old age, you need to cure ageing itself. If, for whatever reason, you think that curing ageing as a whole would be a bad idea and it should not be done, the only option is to not cure at least some of the root causes of ageing. Consequently, some age-related pathologies would remain as untreatable as they are today.

Now, the typical objections raised against rejuvenation tend to sound reasonable at first. To some, the statement ‘We should not cure ageing because it would lead to overpopulation’ sounds self-evident. However, if we consider the implications of this statement, things start getting crazy. As said, not curing ageing implies not curing some of its root causes, which in turn implies not curing some age-related diseases. Therefore, the sentence ‘We should not cure ageing’ implies ‘We should not cure [insert age-related disease here] ‘. What happens when we reformulate typical objections to rejuvenation in this fashion?

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I really wanna know why people don’t get this.

For more information on Aubrey de Grey, please visit our website www.tedxmuenchen.de

Dr. Aubrey de Grey is a biomedical gerontologist based Mountain View, California, USA, and is the Chief Science Officer of SENS Research Foundation, a California-based 501©(3) biomedical research charity that performs and funds laboratory research dedicated to combating the aging process. He is also Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging. He received his BA in computer science and Ph.D. in biology from the University of Cambridge. His research interests encompass the characterisation of all the accumulating and eventually pathogenic molecular and cellular side-effects of metabolism (“damage”) that constitute mammalian aging and the design of interventions to repair and/or obviate that damage.

Continue reading “How we can finally win the fight against aging” | >

Scientists at the Salk Institute have found that intermittent expression of genes normally associated with an embryonic state can reverse the hallmarks of old age. This approach, which not only prompted human skin cells in a dish to look and behave young again, also resulted in the rejuvenation of mice with a premature aging disease, countering signs of aging and increasing the animals’ lifespan by 30 percent. The early-stage work provides insight both into the cellular drivers of aging and possible therapeutic approaches for improving human health and longevity.

Turning back time: Salk scientists reverse signs of aging

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