Human stem cells—the biological jack of all trades—have revolutionized modern medicine, with their ability to transform into specialized cell types.
But the current approach, which requires specialized instructive protein molecules known as growth factors, comes with risks, including the potential development of unwanted tissue, i.e., a tumor.
Researchers at Texas A&M University, however, have discovered a gentler approach.
Many large cities (Seoul, Tokyo, Shenzhen, Singapore, Dubai, London, San Francisco) serve as test beds for autonomous vehicle trials in a competitive race to develop “self-driving” cars. Automated ports and warehouses are also increasingly automated and robotized. Testing of delivery robots and drones is gathering pace beyond the warehouse gates. Automated control systems are monitoring, regulating and optimizing traffic flows. Automated vertical farms are innovating production of food in “non-agricultural” urban areas around the world. New mobile health technologies carry promise of healthcare “beyond the hospital.” Social robots in many guises – from police officers to restaurant waiters – are appearing in urban public and commercial spaces.
Tokyo, Singapore and Dubai are becoming prototype ‘robot cities,’ as governments start to see automation as the key to urban living.
With advances in stem cell research and nanotechnology helping us fight illnesses from heart disease to superbugs, is the fusion of biology and technology speeding us towards a sci-fi future — part human, part synthetic?
In Ridley Scott’s seminal blockbuster Blade Runner, humanity has harnessed bio-engineering to create a race of replicants that look, act and sound human — but are made entirely from synthetic material.
We may be far from realising that sci-fi future, but synthetics are beginning to have a profound effect on medicine.
In a talk given today at the American Association for Cancer Research’s annual meeting, Google researchers described a prototype of an augmented reality microscope that could be used to help physicians diagnose patients. When pathologists are analyzing biological tissue to see if there are signs of cancer — and if so, how much and what kind — the process can be quite time-consuming. And it’s a practice that Google thinks could benefit from deep learning tools. But in many places, adopting AI technology isn’t feasible. The company, however, believes this microscope could allow groups with limited funds, such as small labs and clinics, or developing countries to benefit from these tools in a simple, easy-to-use manner. Google says the scope could “possibly help accelerate and democratize the adoption of deep learning tools for pathologists around the world.”
The microscope is an ordinary light microscope, the kind used by pathologists worldwide. Google just tweaked it a little in order to introduce AI technology and augmented reality. First, neural networks are trained to detect cancer cells in images of human tissue. Then, after a slide with human tissue is placed under the modified microscope, the same image a person sees through the scope’s eyepieces is fed into a computer. AI algorithms then detect cancer cells in the tissue, which the system then outlines in the image seen through the eyepieces (see image above). It’s all done in real time and works quickly enough that it’s still effective when a pathologist moves a slide to look at a new section of tissue.
Human stem cells have shown potential in medicine as they can transform into various specialized cell types such as bone and cartilage cells. The current approach to obtain such specialized cells is to subject stem cells to specialized instructive protein molecules known as growth factors. However, use of growth factors in the human body can generate harmful effects including unwanted tissue growth, such as a tumor.
Researchers at Texas A&M University have explored a new class of clay nanoparticles that can direct stem cells to become bone or cartilage cells.
Dr. Akhilesh Gaharwar, an assistant professor in the Department of Biomedical Engineering, and his students have demonstrated that a specific type of two-dimensional (2-D) nanoparticles, also known as nanosilicates, can grow bone and cartilage tissue from stem cells in the absence of growth factors. These nanoparticles are similar to flaxseed in shape, but 10 billion times smaller in size. Their work, “Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates,” has been published in Proceedings of the National Academy of Sciences this week.
Researchers at the University of Washington have developed a product that uses peptides to promote the regrowth of tooth enamel in order to treat dental cavities.
An end to tooth decay?
There are multiple regenerative medicine approaches being developed to combat tooth decay; for example, earlier this year, we discussed a method that uses gsk3 antagonists to spur the regeneration of teeth. This is a similar approach that is showing promising results.
