That’s what Marji Klima, executive assistant at the Alcor Life Extension Foundation in Scottsdale, Arizona, told me over email this week. She was referring to Dr. James Hiram Bedford, a former University of California-Berkeley psychology professor who died of renal cancer on Jan. 12, 1967. Bedford was the first human to be cryonically preserved—that is, frozen and stored indefinitely in the hopes that technology to revive him will one day exist. He’s been at Alcor since 1991.
His was the first of 300 bodies and brains currently preserved in the world’s three known commercial cryonics facilities: Alcor; the Cryonics Institute in Clinton Township, Michigan; and KrioRus near Moscow. Another 3,000 people still living have arranged to join them upon what cryonicists call “deanimation.” In other words, death.
Mel Gibson is an actor and filmmaker. Neil Riordan, PA, PhD is one of the early pioneers and experts in applied stem cell researchttps://www.cellmedicine.com/
Nearly 500 years ago in what we now call Mexico, a disease started rippling through the population. Red spots appeared on the skin, accompanied by wretched vomiting, bleeding from multiple orifices, and eventually, death. Combined with an invasion from Europe and horrific droughts, it was generally not a pleasant time or place to be alive.
It bore the name cocoliztli, meaning ‘pestilence,’ and it killed between five and 15 million people in just three years. As many plagues were at the time, it proved deadly and mysterious, burning through entire populations. Occurring centuries before John Snow’s work on cholera gave rise to epidemiology, data on the disease’s devastation was sparse. Over the years, researchers and historians attempted to pin the blame for the illness on measles, plague, viral hemorrhagic fevers like Ebola, and typhoid fever—a disease caused by a variation of the bacteria Salmonella enterica.
In a paper published this week in Nature Ecology & Evolution, researchers present evidence that the latter was the most likely candidate in this cast of microbial miscreants. The study was pre-printed in biorxiv last year. The researchers detected the genome of a different variety of Salmonella enterica (the specific variety is Paratyphi C) in teeth of individuals buried in a cemetery historically linked to the deadly outbreak.
But it remains to be seen whether drug regulators will go along with a new way of making medicines. To do so, agencies like the U.S. Food and Drug Administration will need to rewrite their rules for validating the safety of medicines. Instead of signing off on the production facility and manufactured drug samples, regulators would have to validate that reactionware produces the desired medication. Cronin agrees it’s a hurdle. But he argues that future printed reactors could simply include a final module containing standard validation tests that produce a visual readout, much like a pregnancy test. “I think it’s manageable.”
Digitized chemistry on demand could also undermine drug counterfeiters.
The finding was a milestone in the field of anti-aging science. Professor Judith Campisi, Ph.D., a celebrity in the anti-aging field, and lead author of the study remarked
“Imagine the possibility of taking a pill [rapamycin] for a few days or weeks every few years, as opposed to taking something with side effects every day for the rest of your life. It’s a new way of looking at how we could deal with age-related maladies.” – Judith Campisi, PhD
Campisi’s discovery suggests that a person could take rapamycin intermittently, say, once a week, shutting down the chronic inflammation. Because the zombie cells haven’t gone away, they will eventually find their footing and start the inflammatory ball rolling once again. A person on this regimen would repeat the dosage intermittently and substantially reduce inflammation.
In a new study, MIT scientists have developed nanoparticles that deliver the CRISPR gene editing system, eliminating the need to use viruses for delivery.
Using the new delivery technique, the gene editors were able to cut out genes in about 80 percent of liver cells, the best success rate ever achieved with CRISPR in adult animals. Speaking about the success of the project, Daniel Anderson, senior author of the study and an associate professor in MIT’s Department of Chemical Engineering, said.
High-tech warfare at knife-fight ranges: that’s the ugly future of urban combat. If you thought Baghdad was bad, with its roughly six million people, imagine a “megacity” of 10 or 20 million, where the slums have more inhabitants than some countries. Imagine a city of the very near future where suspicious locals post every US military movement on Twitter with digital photos and GPS-precise coordinates. Imagine roadside bombs that fly because the bad guys downloaded blueprints for a kamikaze mini-drone and built it with their 3D printer.
As the US pulls out of the mountains and deserts of Afghanistan, the Navy and Air Force may be looking to the wide-open Pacific, but the Army is increasingly concerned about the cramped alleyways of Third World cities. (The Marines, as usual, have a foot in both worlds). Chief of Staff Ray Odierno’s personal Strategic Studies Group — now led by hybrid warfare expert David Johnson — is working on the subject, as is the Army’s think tank and teaching institution, Training and Doctrine Command (TRADOC). This August, after months of seminars, simulations, and study, the Army War College will host a “deep future wargame” set in a megacity, probably a coastal one, circa 2035.
“We talk about the danger of failed states: Imagine a failed megacity,” offers Col. Kevin Felix of TRADOC’s Army Capability Integration Center (ARCIC), which plays a leading role in organizing the wargame. Even a partial breakdown of security and public services could put thousands of people in peril — or under the rule of drug gangs, as in Brazil’s infamous favelas; or of terrorist groups, like Hezbollah in parts of Lebanon. In those parts of the city, Felix told me, “there may be order, but I wouldn’t define it as law and order.”
