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Category: biotech/medical – Page 2,460

Examining trapped ion technology for next generation quantum computers

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Quantum computers (QC) are poised to drive important advances in several domains, including medicine, material science and internet security. While current QC systems are small, several industry and academic efforts are underway to build large systems with many hundred qubits.

Towards this, computer scientists at Princeton University and physicists from Duke University collaborated to develop methods to design the next generation of quantum computers. Their study focused on QC systems built using trapped ion (TI) technology, which is one of the current front-running QC hardware technologies. By bringing together computer architecture techniques and device simulations, the team showed that co-designing near-term hardware with applications can potentially improve the reliability of TI systems by up to four orders of magnitude.

Their study was conducted as a part of the Software-Tailored Architecture for Quantum co-design (STAQ) project, an NSF funded collaborative research effort to build an trapped-ion quantum computer and the NSF CISE Expedition in Computing Enabling Practical-Scale Quantum Computing (EPiQC) project. It was published recently in the 2020 ACM/IEEE International Symposium on Computer Architecture.

State Reports No COVID-19 Deaths Since Yesterday; ‘First Time In Months:’ Governor

COVID-19 hospitalizations in Connecticut increased by 14 since Monday, but the state is reporting no new coronavirus-related deaths for the “first time in months,” Governor Ned Lamont announced at a press conference Tuesday afternoon.

“I’m paid to worry,” the governor said when talking about the hospitalizations increasing. “I would worry if I saw our admissions in our hospitals going up and that’s why you saw hospitalizations going up. That’s not what happened. We’ve added between about 20 and 30 new COVID cases a day into our hospitals. That’s consistent. That’s been consistent for the last few weeks. What is happened is there are many fewer discharges. It’s not something I worry about, just something I note to you.”

According to the state Department of Health, 5,745 tests have been administered since yesterday, and just 57 new cases were reported. Lamont said the state’s positive test percentage remains around one percent.

An intriguing—but far from proven—HIV cure in the ‘São Paulo Patient’

A 36-year-old man in Brazil has seemingly cleared an HIV infection—making him the proof of principle in humans of a novel drug strategy designed to flush the AIDS virus out of all of its reservoirs in the body. But scientists caution that the success hasn’t been long or definitive enough to label it a cure…so granted it worked, not so fast.

Vitamin and antiviral drugs appear to clear AIDS virus, but it could still be hiding out in tissue reservoirs.

High Blood Pressure May Lead to Low Brain Volume

Having hypertension in midlife (ages 40 through 60) is associated with elevated risk of cognitive impairment and Alzheimer’s dementia later in life, even more so than having the so-called Alzheimer’s gene.

“It is clear that cerebral vascular disease”—that is, hardening of the arteries inside our brain—“and cognitive decline travel hand in hand,” something I’ve addressed before. “However, the independent association of AD [Alzheimer’s disease] with multiple AVD [atherosclerotic vascular disease] risk factors suggests that cholesterol is not the sole culprit in dementia.”

As I discuss in my video Higher Blood Pressure May Lead to Brain Shrinkage, one of the most consistent findings is that elevated levels of blood pressure in midlife, ages 40 through 60, is associated with elevated risk of cognitive impairment and Alzheimer’s dementia later in life—in fact, even more so than having the so-called Alzheimer’s gene.

More Humanin Increases Chances for Healthier Living to 100

Aging/longevity/heathspan fans!!

Higher levels of humanin, a peptide encoded in the small genome of the mitochondria, in the body is linked to longer lifespans and better health.

Aging Journal – The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

The scientists observed that species which are already predisposed to long life, including the naked mole rat had high levels of humanin, while mice, in contrast, experience a 40% decrease in humanin over the first 18 months of their life and primates experienced a similar notable decrease between the ages of 19 and 25.

Fighting Antibody Cocktail Being Tested in Thousands of People

An antibody cocktail designed to prevent and treat COVID-19 is now entering late-stage clinical trials, according to reports.

When naturally infected with COVID-19, the body generates Y-shaped molecules called antibodies that latch onto the virus and mark it for destruction, or hinder its ability to infect healthy cells, Live Science previously reported. These antibodies can be drawn from recovered COVID-19 patients and injected into sick patients to bolster their immune systems against the virus, a treatment known as convalescent plasma therapy.

Novavax Secures $1.6 Billion from U.S. Government for COVID-19 Vaccine Program

Gaithersburg, Md.-based Novavax said the funding will allow the company to participate in Operation Warp Speed, the government’s program that has a goal of supporting the development of hundreds of millions of vaccine doses by 2021. The funding granted to Novavax will support the late-stage clinical development of the vaccine candidate, including a pivotal Phase III study. Additionally, the funds will be used to establish large-scale manufacturing in order to deliver 100 million doses of NVX‑CoV2373 by the end of the year.

Stanley C. Erck, president and chief executive officer of Novavax, said the company was honored to partner with Operation Warp Speed, a program that is supporting multiple shots on goal against COVID-19 by backing multiple vaccine projects, including Moderna’s mRNA program and AstraZeneca’s vaccine candidate.

“The pandemic has caused an unprecedented public health crisis, making it more important than ever that industry, government and funding entities join forces to defeat the novel coronavirus together. We are grateful to the U.S. government for its confidence in our technology platform, and are working tirelessly to develop and produce a vaccine for this global health crisis,” Erck said in a statement.

Among older adults, statin use tied to decreased risk of death

Study after study has shown that statins can prevent heart attacks, strokes and death in middle-aged adults. But in 28 major clinical trials of statins, only 2 percent of participants have been 75 years or older. This means that even though older adults are at greater risk of heart disease and death, there is scant data on whether statins should be prescribed for them.

A new study led by investigators from Brigham and Women’s Hospital and VA Boston Healthcare System leverages national data from the U.S. Veterans Health Administration Services and Centers for Medicare & Medicaid Services to shed new light on the role statins may play for older adults who have not yet experienced a , stroke or other cardiovascular event. In their retrospective analysis, the researchers found that the risk of dying from any cause was lower by 25 percent among veterans who were using statins compared to those who were not treated with statins. The risk of dying from a cardiovascular event, such as a heart attack or stroke, was lower by 20 percent. The team’s results are published in JAMA.

“Based on these data, age is not a reason to not prescribe statins,” said lead and corresponding author Ariela Orkaby, MD, MPH, a physician scientist at VA Boston Health Care System and in the Division of Aging at the Brigham. “Statins are commonly studied and prescribed for middle-aged adults but understudied in people over age 75. One of the most remarkable things about our results is that we found the benefit of statins held true regardless of whether a person was older or younger or had a condition such as dementia.”

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