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Human dental pulp stem cells: Applications in future regenerative medicine

Stem cells are pluripotent cells, having a property of differentiating into various types of cells of human body. Several studies have developed mesenchymal stem cells (MSCs) from various human tissues, peripheral blood and body fluids. These cells are then characterized by cellular and molecular markers to understand their specific phenotypes. Dental pulp stem cells (DPSCs) are having a MSCs phenotype and they are differentiated into neuron, cardiomyocytes, chondrocytes, osteoblasts, liver cells and β cells of islet of pancreas. Thus, DPSCs have shown great potentiality to use in regenerative medicine for treatment of various human diseases including dental related problems. These cells can also be developed into induced pluripotent stem cells by incorporation of pluripotency markers and use for regenerative therapies of various diseases. The DPSCs are derived from various dental tissues such as human exfoliated deciduous teeth, apical papilla, periodontal ligament and dental follicle tissue. This review will overview the information about isolation, cellular and molecular characterization and differentiation of DPSCs into various types of human cells and thus these cells have important applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as scientists working in the field of oral pathology and oral medicine.

Keywords: Human dental pulp stem cells, Mesenchymal stem cells, Dentin, Pluripotency, Stem cell therapy, Molecular markers.

Core tip: Human dental pulp stem cells (DPSCs) have shown a potentiality for the treatment of various human diseases including dental related problems. The review will overview the information about DPSCs, their isolation, cellular and molecular characterization, differentiation into various types of cells and their applications in regenerative therapies for various diseases. This review will be most useful for postgraduate dental students as well as the scientists working in the field of oral pathology, oral medicine and regenerative medicine.

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Heavy metals like arsenic and lead found in 45 packaged fruit juices, report finds

A new report out Wednesday says some popular fruit juices may contain heavy metal contaminants like lead, arsenic, and cadmium. Consumer Reports tested 45 packaged fruit juices and found measurable levels of heavy metal in every product. Long-term exposure to these metals could cause serious health risks, including kidney disease and certain types of cancer. Anna Werner reports.

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PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years? | Modern Wisdom Podcast #066

David Sinclair is a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul Glenn Centre for the Biological Mechanisms of Ageing.

Today we hear from a scientist at the cutting edge of longevity research as Professor Sinclair gives us a fascinating insight into the world of anti-ageing.

Expect to learn how and why we age, why stabilising the epigenetic landscape may enable a human to live for 1000 years, exactly what tactics Professor Sinclair is using himself to try and extend his life and how fasting, Sirtuins and NAD can be used to promote health and reduce diseases.

Extra Stuff:
David’s New Book — http://lifespanbook.com/
Follow David on Twitter — https://twitter.com/davidasinclair
Inside Tracker — https:// www.insidetracker.com
Recommended Books — https://www.amazon.co.uk/shop/chriswillx

Listen to all episodes online. Search “Modern Wisdom” on any Podcast App or click here:
iTunes: https://apple.co/2MNqIgw
Spotify: https://spoti.fi/2LSimPn
Stitcher: https://www.stitcher.com/podcast/modern-wisdom

I want to hear from you!! Get in touch in the comments below or head to…

Continue reading “PROFESSOR DAVID SINCLAIR | Can Humans Live For 1000 Years? | Modern Wisdom Podcast #066” | >

Cell injection helps restoration of lost muscle mass in mice

Anyone who’s been laid up for an extended period due to illness or injury will know how difficult it can be to get moving again. Long-term immobility can see a loss of muscle mass that can be hard to regain, especially for the elderly. In research on mice, a team at the University of Illinois at Urbana-Champaign have found that the injection of a type of cells known to promote blood vessel growth helps accelerate to restoration of muscle mass lost due to inactivity.

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CRISPR accuracy increased 50-fold

Biomedical engineers at Duke University, North Carolina, have developed a method for improving the accuracy of CRISPR genome editing by an average of 50-fold. They believe it can be easily translated to any of the technology’s continually expanding formats.

The approach adds a short tail to the guide RNA which is used to identify a sequence of DNA for editing. This added tail folds back and binds onto itself, creating a “lock” that can only be undone by the targeted DNA sequence.

“CRISPR is generally incredibly accurate, but there are examples that have shown off-target activity, so there’s been broad interest across the field in increasing specificity,” said Charles Gersbach, Professor of Biomedical Engineering at Duke. “But the solutions proposed thus far cannot be easily translated between different CRISPR systems.”

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