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Can We Really Live Forever? | Unveiled

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We’ve been raised with the belief that death is inevitable, and so during our lives we consider the legacy of what each of us leaves behind. But what if you had unlimited time to pursue your life’s work, your hobbies, and your dreams.

What if you didn’t have to die? As science and medicine advances, the average human lifespan continues to increase from better care and medicines that treat diseases. Some scientists say that in the near future, perhaps within the next 50 years, immortality might be within our grasp.

To begin to understand the aging process, we have to look at the laws of physics. There are four laws of thermodynamics, and the second law of thermodynamics basically implies that everything made up of atoms rusts, falls apart and disintegrates. We are all made of atoms, and those atoms must obey the second law of thermodynamics.

Currently there are drugs based on small molecules called senolytics which are designed to eliminate these zombie cells which refuse to die. This is a good thing, because such defective senescent cells persist to emit harmful chemicals that damage other healthy cells, and cause inflammation; a process that is one of the basic mechanisms of aging. But this is only a small part of the process.

Who shrank the drug factory? Briefcase-sized labs could transform medicine

Historically, the pharmaceutical industry has relied on economies of scale, mixing hundreds of litres of reagents in massive reaction chambers to make millions of doses of a single drug. Bio-MOD and related systems, however, cycle small amounts of chemicals through a series of thumb-sized chambers that can produce hundreds or thousands of doses of multiple drugs, all in less than 24 hours. Several teams have won support for this vision from the US military: the Defense Advanced Research Projects Agency (DARPA) has handed out more than US$15 million to support these do-it-yourself drug-makers.

Engineers are miniaturizing pharmaceutical production in the hope of making it portable and inexpensive.

Artificial wombs may soon become the future — but what are the risks?

The idea of growing babies outside the body has inspired novels and movies for decades.

Now, research groups around the world are exploring the possibility of artificial gestation. For instance, one group successfully grew a lamb in an artificial womb for four weeks. Australian researchers have also experimented with artificial gestation for lambs and sharks.

And in recent weeks, researchers in The Netherlands have received €2.9 million to develop a prototype for gestating premature babies.

Research team discovers epigenetic pathway that controls social behavior in carpenter ants

Through early adulthood, exposure to new experiences—like learning to drive a car or memorizing information for an exam—triggers change in the human brain, re-wiring neural pathways to imprint memories and modify behavior. Similar to humans, the behavior of Florida carpenter ants is not set in stone—their roles, whether it is protecting the colony or foraging for food, are determined by signals from the physical and social environment early in their life. But questions remain about how long they are vulnerable to epigenetic changes and what pathways govern social behavior in ants.

Now, a team led by researchers in the Perelman School of Medicine at the University of Pennsylvania discovered that a protein called CoRest, a neural repressor that is also found in humans, plays a central role in determining the of . The results, published today in Molecular Cell, also revealed that called Majors, known as “brawny” soldiers that protect colonies, can be reprogrammed to perform the foraging role—generally reserved for their sisters, the Minor ants—up to five days after they emerge as an adult ant. However, the reprogramming is ineffective at the 10-day mark, revealing how narrow the window of epigenetic plasticity is in ants.

“How becomes established in humans is deeply fascinating—we know it’s quite plastic especially during childhood and early adolescence—however, of course, we cannot study or manipulate this experimentally,” said the study’s senior author Shelley Berger, Ph.D., the Daniel S. Och University Professor in the departments of Cell and Developmental Biology and Biology, and director of the Penn Epigenetics Institute. “Ants, with their complex societies and behavior, and similar plasticity, provide a wonderful laboratory model to understand the underlying mechanisms and pathways.

How Gene Therapy can Help You Stop Aging, Build Muscles, and Fight Diseases

On this episode of Anti-Aging Hacks show, we get into the following topics:

1. What is Gene Therapy and how Practical is it?

2. How Gene Therapies or Gene Editing help you Stop Aging, Build Muscle and Fight Disease?

3. Could you take your body back to your much younger self?

My guest is Liz Parrish, and Liz is a humanitarian, entrepreneur, innovator, and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of regenerative medicine modalities, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and is a founding member of the International Longevity Alliance (ILA).

Here are the highlights from our conversation:

Continue reading “How Gene Therapy can Help You Stop Aging, Build Muscles, and Fight Diseases” | >

The gut may be the ticket to reducing chemo’s side effects

In a new study, scientists observed several simultaneous reactions in mice given a common chemotherapy drug: Their gut bacteria and tissue changed, their blood and brains showed signs of inflammation, and their behaviors suggested they were fatigued and cognitively impaired.

The research is the first to show these combined events in the context of chemotherapy, and opens the door to the possibility that regulating could not only calm chemo side effects like nausea and diarrhea, but also potentially lessen the memory and concentration problems many cancer survivors report.

More research is needed to further understand how the chemo-modified gut influences the in a way that can have an impact on behavior. The same lab at The Ohio State University is continuing mouse studies to test the relationship and running a parallel clinical trial in .

Engineer Finds Way to Pull Diseases From Blood Using Magnets

A British engineer has found a way to filter unwanted cells from blood using magnets — and his tool could be used in clinical trials as soon as next year.

Thanks to existing research, biochemical scientist George Frodsham knew it was possible to force magnetic nanoparticles to bind to specific cells in the body. But while other researchers did so primarily to make those cells show up in images, he wondered whether the same technique might allow doctors to remove unwanted cells from the blood.

“When someone has a tumour you cut it out,” he told The Telegraph. “Blood cancer is a tumour in the blood, so why not just take it out in the same way?”

Gene-editing Gets Major Funding

The program, called Somatic Cell Genome Editing, will be investing $190 million. (2018)

Last year, I wrote about a team of Chinese scientists having received ethical approval to perform a clinical trial of gene-editing. The goal was to test whether gene-editing may be a potential cure for cancer. The technology used for the trial is called CRISPR/Cas9, not exactly a household name. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. Cas9 stands for CRISPR associated protein 9, an RNA-guided DNA endonuclease enzyme. If you read all these words a few times, it can make your head hurt. The topic is complex, but I hope in this post to make it more understandable.

After reading about CRISPR more than a few times, I think I finally get the concept. I may not have this 100% right, but following is what I believe it is about. To imagine what gene-editing is, consider editing of a video. The software shows you each frame of the video. You select a frame you want to edit and display the frame in video editing software. You make the changes to look the way you want the frame to look, and then insert the frame back into the video. For example, the original video may have contained an unneeded “um” or “ah” or “eh” which added no value to the video.

Now, consider the similarity with gene-editing. The human body has T-cells which are an active participant in our immune system. A gene in the T-cells can produce a protein called PD-1 which disables the T-cells’ ability to trigger an immune response to fight cancer. A team of oncologists removed cells from an advanced stage lung cancer patient and edited the cells using CRISPR-Cas9. After editing out the gene which blocks the immune response, the cells were cultured and multiplied and then injected back into the patient.

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