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Category: biotech/medical – Page 2,374

Prospective Validation of an Electronic Health Record–Based, Real-Time Suicide Risk Model

Importance Numerous prognostic models of suicide risk have been published, but few have been implemented outside of integrated managed care systems.

Objective To evaluate performance of a suicide attempt risk prediction model implemented in a vendor-supplied electronic health record to predict subsequent suicidal ideation and suicide attempt.

Design, Setting, and Participants This observational cohort study evaluated implementation of a suicide attempt prediction model in live clinical systems without alerting. The cohort comprised patients seen for any reason in adult inpatient, emergency department, and ambulatory surgery settings at an academic medical center in the mid-South from June 2019 to April 2020.

WWII codebreaker Turing honored on UK’s new 50-pound note

LONDON (AP) — The rainbow flag flew proudly Thursday above the Bank of England in the heart of London’s financial district to commemorate World War II codebreaker Alan Turing, the new face of Britain’s 50-pound note.

The design of the bank note was unveiled before it is being formally issued to the public on June 23, Turing’s birthday. The 50-pound note is the most valuable denomination in circulation but is little used during everyday transactions, especially during the coronavirus pandemic as digital payments increasingly replaced the use of cash.

The new note, which is laden with high-level security features and is made of longer-lasting polymer, completes the bank’s rejig of its paper currencies over the past few years. Turing’s image joins that of Winston Churchill on the five-pound note, novelist Jane Austen on the 10-pound note and artist J. M. W. Turner on the 20-pound note.

How Humans Develop Larger Brains Than Other Apes

Summary: Using brain organoid models, researchers have identified how the brain grows much larger and has three times as many neurons, as the brains of chimpanzees and gorillas.

Source: UK Research and Innovation.

A new study is the first to identify how human brains grow much larger, with three times as many neurons, compared with chimpanzee and gorilla brains. The study, led by researchers at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, UK, identified a key molecular switch that can make ape brain organoids grow more like human organoids, and vice versa.

Medicine 2.0 – Successful Repair of Aging Damage

Antiaging expert Aubrey de Grey says there is a 50% chance that we reach longevity escape velocity by 2035.

I now think there is a 50% chance that we will reach longevity escape velocity by 2036. After that point (the “Methuselarity”), those who regularly receive the latest rejuvenation therapies will never suffer from age-related ill-health at any age.

— Aubrey de Grey (@aubreydegrey) March 142021

More Than Words: Using AI to Map How the Brain Understands Sentences

Summary: Combining neuroimaging data with artificial intelligence technology, researchers have identified a complex network within the brain that comprehends the meaning of spoken sentences.

Source: university of rochester medical center.

Have you ever wondered why you are able to hear a sentence and understand its meaning – given that the same words in a different order would have an entirely different meaning?

A novel marker of adult human neural stem cells discovered

Should interest those into links on aging/longevity and neuroscience.

The mammalian center for learning and memory, hippocampus, has a remarkable capacity to generate new neurons throughout life. Newborn neurons are produced by neural stem cells (NSCs) and they are crucial for forming neural circuits required for learning and memory, and mood control. During aging, the number of NSCs declines, leading to decreased neurogenesis and age-associated cognitive decline, anxiety, and depression. Thus, identifying the core molecular machinery responsible for NSC preservation is of fundamental importance if we are to use neurogenesis to halt or reverse hippocampal age-related pathology.

While there are increasing number of tools available to study NSCs and neurogenesis in mouse models, one of the major hurdles in exploring this fundamental biological process in the human brain is the lack of specific NSCs markers amenable for advanced imaging and in vivo analysis. A team of researchers led by Dr. Mirjana Maletić-Savatić, associate professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, and Dr. Louis Manganas, associate professor at the Stony Brook University, decided to tackle this problem in a rather unusual way. They reasoned that if they could find proteins that are present on the surface of NSCs, then they could eventually make agents to “see” NSCs in the .

“The ultimate goal of our research is to maintain neurogenesis throughout life at the same level as it is in the young brains, to prevent the decline in our cognitive capabilities and reduce the tendency towards mood disorders such as depression, as we age. To do that, however, we first need to better understand this elusive, yet fundamental process in humans. However, we do not have the tools to study this process in live humans and all the knowledge we have gathered so far comes from analyses of the postmortem brains. And we cannot develop tools to detect this process in people because existing NSC markers are present within cells and unreachable for in vivo visualization,” Maletić-Savatić said. “So, in collaboration with our colleagues from New York and Spain, we undertook this study to find surface markers and then develop tools such as ligands for positron emission tomography (PET) to visualize them using advanced real-time in vivo brain imaging.”

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