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(HealthDay)—Get up off of the couch: Sitting too much may kill you even if you exercise regularly.

If you sit for six hours a day or more, your risk of dying early jumps 19 percent, compared with people who sit fewer than three hours, an American Cancer Society study suggests.

And, the study authors added, sitting may kill you in 14 ways, including: cancer; heart disease; stroke; diabetes; kidney disease; suicide; chronic (COPD); lung disease; liver disease; peptic ulcer and other ; Parkinson’s disease; Alzheimer’s disease; nervous disorders; and .

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Researchers at the University of Alabama at Birmingham have shown—for the first time—that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism.

This novel finding, reported in the journal Nature Medicine, is important because, despite significant advances to reveal the pathological mechanisms of persistent , effective treatment interventions are lacking.

Pulmonary fibrosis can develop after injuries like infections, radiation or chemotherapy, or it can have an unknown cause, as in , or IPF is a progressive, and ultimately fatal, that strikes more than 150,000 patients a year in the United States and more than 5 million worldwide.

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Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued to grow at an ever-increasing pace. Now, there are many researchers engaged in exploring senescent cells and their role in aging and disease.

Lately, there has been enthusiastic interest in developing therapies to remove these problematic senescent cells, but are there potentially better ways to deal with senescent cells beyond periodically purging them with senolytic drugs and therapies?

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LEAF’s monthly rejuvenation roundup is out!


July is here, and our upcoming conference in New York City is only a handful of days away! If you haven’t done so already, go and get your ticket now so that you can enjoy the June roundup fully relaxed, knowing that your seat is secured.

About our NYC conference

On the off chance you’ve missed the news about it, Ending Age-Related Diseases: Investment Prospects & Advances in Research is our first conference to be held in New York City. It will take place on July 12th at Cooper Union, and it will feature talks and panels with several great speakers, such as Dr. Vera Gorbunova from Rochester University, Dr. Vadim Gladyshev from Harvard Medical School, Dr. Aubrey de Grey from SENS Research Foundation, Dr. Kelsey Moody from Ichor Therapeutics, and many more. You can get your ticket here, and remember that Lifespan Heroes get 75% off the ticket price!

A being that can consciously alter its own DNA via technological intervention (i.e. cybernetic means) is what our Second Womb has been nurturing. We have used civilization to protect ourselves while we crack the code of our biological being. We started in the womb of the cave. Then moved on to the womb of the hut. Then the village, the city, and the state. All thew hile, we have been tinkering with our own DNA and the DNA of other species. To me, this is the real posthuman or transhuman — it is the creature that is actively editing its own biological blueprint through tech. This is what we’ve been doing since we started augmenting our bodies with clothing and animal skins. We’ve been modifying our ability to endure the slings and arrows of the cosmos.


What is human civilization? It is difficult to assert that other animals do not create their own civilizations — termites for instance meet some criteria for being categorized as cyborgs (building temperature-controlled mega structures). Animals communicate, express feelings, and have personalities. Octopi arrange furniture for would-be mates. Others engage in mating rituals. Some mourn the dead. Birds can solve simple math. Critters scheme, enterprise, forge bonds, and even produce art. What do we do that animals do not?

To our credit, we are the only animals that record, share, and develop history upon structures and materials outside of our bodies. We harness energy for massive projects. We farm, but again, so do leaf-cutter ants. But we create genetically novel vegetables and animals. We alter the global climate. Our enterprises are global, and given time and opportunity, our projects will eventually become exostellar. We do all this rather ferociously. Human history is a rather short explosion of civilization-building activities, and yet it might already have irrevocably altered the future of all life on this planet. No other creature has created a circumstance quite like that of human beings and our anthropocene project. For instance, unless we clean up the environment, the next few generations of plant and animal life are going to have be extremely resilient to radiation, Styrofoam, plastics, and other run-offs squeezed out from the human project. That is just a fact of life now on earth.

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