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Amidst the ongoing threat of the California wildfires, a Tesla Model 3 owner has posted a brief demonstration of the electric sedan’s capability to maintain the air quality inside its cabin, despite the vehicle not being equipped with the Model S and X’s hospital-grade HEPA filter or a dedicated “Bioweapon Defense Mode.”

Elon Musk took to Twitter last week to offer the Model S and Model X as vehicles that can be used to transport people away from the ongoing CA wildfires. The Model S and X are capable of scrubbing the air inside the car, thanks to their large HEPA filters that are fitted with separate acid and alkaline gas neutralization layers. Later social media updates and anecdotes from Model S and X owners driving through the CA area indicate that Bioweapon Defense Mode helped maintain the air quality inside their vehicles.

In a follow-up tweet, Elon Musk noted that the Model 3’s air filtration system is not on the same “hospital-grade” level as that of the Model S and X, since the smaller vehicle does not have enough space to accommodate the HEPA filtration system in Tesla’s two flagship vehicles. This could be seen in the parts catalog for the vehicles, where the Model X HEPA filter was listed as “FILTER, HEPA, MDL X,” while the Model 3’s system was simply listed as “HVAC, CABIN FILTER, M3.”

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The Cancer Genome Atlas (TCGA) provides a high-quality resource of molecular data on a large variety of human cancers. Corces et al. used a recently modified assay to profile chromatin accessibility to determine the accessible chromatin landscape in 410 TCGA samples from 23 cancer types (see the Perspective by Taipale). When the data were integrated with other omics data available for the same tumor samples, inherited risk loci for cancer predisposition were revealed, transcription factors and enhancers driving molecular subtypes of cancer with patient survival differences were identified, and noncoding mutations associated with clinical prognosis were discovered.

Science, this issue p. eaav1898; see also p. 401.

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Government representatives from nearly 170 countries will this month consider whether to temporarily ban the release of organisms carrying gene drives — a controversial technology that can quickly propagate a chosen gene throughout a population. The technique has the potential to eradicate disease, control pests and alter entire ecosystems, but with unpredictable consequences — leading some groups to call for a global moratorium on its field applications.


Research is moving fast on the divisive genetic technology, which could help to eradicate diseases but also risks altering ecosystems in unpredictable ways.

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Michael B. Fossel, M.D., Ph.D. (born 1950, Greenwich, Connecticut) was a professor of clinical medicine at Michigan State University and is the author of several books on aging, who is best known for his views on telomerase therapy as a possible treatment for cellular senescence. Fossel has appeared on many major news programs to discuss aging and has appeared regularly on National Public Radio (NPR). He is also a respected lecturer, author, and the founder and former editor-in-chief of the Journal of Anti-Aging Medicine (now known as Rejuvenation Research).

Prior to earning his M.D. at Stanford Medical School, Fossel earned a joint B.A. (cum laude) and M.A. in psychology at Wesleyan University and a Ph.D. in neurobiology at Stanford University. He is also a graduate of Phillips Exeter Academy. Prior to graduating from medical school in 1981, he was awarded a National Science Foundation fellowship and taught at Stanford University.

In addition to his position at Michigan State University, Fossel has lectured at the National Institute for Health, the Smithsonian Institution, and at various other universities and institutes in various parts of the world. Fossel served on the board of directors for the American Aging Association and was their executive director.

Fossel has written numerous articles on aging and ethics for the Journal of the American Medical Association and In Vivo, and his first book, entitled Reversing Human Aging was published in 1996. The book garnered favorable reviews from mainstream newspapers as well as Scientific American and was published in six languages. A magisterial academic textbook on by Fossel entitled Cells, Aging, and Human Disease was published in 2004 by Oxford University Press.

Since his days as a teacher at Stanford University, Fossel has studied aging from a medical and scientific perspective with a particular emphasis on premature aging syndromes such as progeria, and since at least 1996 he has been a strong and vocal advocate of [telomerase therapy]] as a potential treatment of age-related diseases, disorders, and syndromes such as progeria, Alzheimer’s disease, atherosclerosis, osteoporosis, cancer, and other conditions. However, he is careful to qualify his advocacy of telomerase therapy as being a potential treatment for these conditions rather than a “cure for old age” and a panacea for age-related medical conditions, albeit a potential treatment that could radically extend the maximum human life span and reverse the aging process in most people. Specifically, Fossel sees the potential of telomerase therapy as being the single most effective point of intervention in a wide variety of age-related medical conditions. His new book, The Telomerase Revolution, (BenBella, 2015) gives a careful explanation of aging, age-related diseases, and the prospects for intervention, including upcoming human trials.

ASHEVILLE, North Carolina — A chickenpox outbreak at a private school now ranks as North Carolina’s largest since a vaccine for the virus became available more than 20 years ago, health officials say.

As of Friday, 36 students at Asheville Waldorf School had contracted the varicella virus, known to most as chickenpox. The school has one of the highest vaccination religious exemption rates in the state.

The viral infection manifests in an itchy rash in most cases and is not typically life-threatening. But the outbreak at Asheville Waldorf should cause concern, said Dr. Jennifer Mullendore of Buncombe County Department of Health and Human Services.

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A tiny transparent worm could be the key to finding out how to stop the frailty and ill health which often comes with old age.

British scientists are sending tens of thousands of worms into space in a government backed project to see if two drugs can prevent or slow down muscle wasting brought on by microgravity.

In space, the 1mm long c-elegans worms have nothing to push against to maintain their muscle mass and so quickly start losing strength, mirroring the effect experienced by elderly people back on Earth or those with conditions like muscular dystrophy.

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