Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2283

This is not hyperbole. AMR already leads to at least 700,000 deaths every year. But the impact goes further — resistant genes in people and animals cross ecological, species and geographical borders. Progress against diseases including HIV, malaria and tuberculosis is threatened globally. In 2016, the World Health Organization reported that nearly half a million people developed drug-resistant tuberculosis. Even cancer patients are more at risk as most treatments suppress the immune system and would, along with several routine surgical operations, become too risky without effective antibiotics.

The world urgently needs a new financing model for antibiotics.

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A small team of Israeli scientists think they might have found the first complete cure for cancer.

“We believe we will offer in a year’s time a complete cure for cancer,” said Dan Aridor, of a new treatment being developed by his company, Accelerated Evolution Biotechnologies Ltd. (AEBi), which was founded in 2000 in the ITEK incubator in the Weizmann Science Park. AEBi developed the SoAP platform, which provides functional leads to very difficult targets. “Our cancer cure will be effective from day one, will last a duration of a few weeks and will have no or minimal side-effects at a much lower cost than most other treatments on the market,” Aridor said. “Our solution will be both generic and personal.”

It sounds fantastical, especially considering that an estimated 18.1 million new cancer cases are diagnosed worldwide each year, according to reports by the International Agency for Research on Cancer. Further, every sixth death in the world is due to cancer, making it the second leading cause of death (second only to cardiovascular disease).

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Attitudes about life extension have significantly changed within the last decade.

While medical schools have had the idea that aging should be brought under medical control for over a century, the explicit desire to greatly extend one’s life remained rare – until very recently. A new study by YouGov, a market intelligence company that researches multiple topics, found that, today, one in five Americans agrees with the statement “I want to live forever.” Is this the result of some sort of bias, or does it mean that we are reaching a turning point, after which society will start boldly and unambiguously clamoring for the cure for aging?

The desire for a long life

The wish to remain healthy and young and live significantly longer has accompanied humanity since its dawn. The most ancient myths and the very first pieces of literature, such as the Epic of Gilgamesh, tried to explain human aging and mortality, and they pictured heroes who pursued ways to live indefinitely or to save their loved ones. These early motivations are woven into modern religions, and they eventually caused life and health to be considered universal human rights that have to be valued and protected.

Continue reading “The American Public Increasingly Desires Life Extension” | >

#OpenAccess #FullArticle The results of a new clinical trial have shown the safety and efficacy of the interoperable Artificial Pancreas System smartphone app (iAPS), which can interface wirelessly with leading continuous glucose monitors (CGM), insulin pump devices, and decision-making algorithms. The clinical trial and the app, which runs on an unlocked smartphone, are described in an article published in Diabetes Technology & Therapeutics (DTT), a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Diabetes Technology & TherapeuticsVol. 21, No. 1Original ArticlesFree AccessSunil Deshpande,…

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A movie montage for modern artificial intelligence might show a computer playing millions of games of chess or Go against itself to learn how to win. Now, researchers are exploring how the reinforcement learning technique that helped DeepMind’s AlphaZero conquer chess and Go could tackle an even more complex task—training a robotic knee to help amputees walk smoothly.

Computer algorithms help prosthetics wearers walk within minutes rather than requiring hours of training.

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CRISPR/Cas9 is a form of genetic editing that holds a lot of promise, such as the killing of cancer cells, but also comes with some hefty warnings, such as that it may cause DNA damage. So far, scientists have been using CRISPR/Cas9 in a variety of plants and animals to edit genetic information, including attempts to practice what is called ‘active genetics’.

This last approach is an attempt to edit the genome that controls which of the two copies of a gene is passed to the next generation. But the technique is complicated and rife with obstacles so thus far been used only on insects. Not anymore!

A team of biologists has now achieved the world’s first CRISPR/Cas9-based approach to control genetic inheritance in a mammal.

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Researchers have achieved a new kind of chimeric first, producing sheep-human hybrid embryos that could one day represent the future of organ donation – by using body parts grown inside unnatural, engineered animals. Scientists have created the first interspecies sheep-human chimera, introducing human stem cells into sheep embryos, resulting in a hybrid creature that’s more than 99 percent sheep – but also a tiny, little bit like you and me.

Admittedly, the human portion of the embryos created in the experiment – before they were destroyed after 28 days – is exceedingly small, but the fact it exists at all is what generates considerable controversy in this field of research.

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