Article courtesy of Dr. Nicholas DiNubile, Vice President of the A4M, an orthopedic surgeon specializing in sports medicine, best selling author, keynote speaker, and one of our medical editors who is dedicated to keeping you healthy in body, mind and spirit.
We’ve extended the warranty on the human heart, and people are living longer. We’ve improved care for skin, and people look better. But it’s your frame that gets you where you need to go whenever you need to get there. Without the proper care, your bones and joints can all too easily become the limiting factor in your enjoyment of life. Have you outlived the warranty on your frame? Would you like an extended warranty?
I have come to believe that the achievement of longevity will bring the challenge of durability to the forefront of modern healthcare.
According to a study published in the European Journal of Preventive Cardiology brushing your teeth frequently is linked to a lower risk of atrial fibrillation and heart failure.
Poor oral hygiene leads to bacteria in the blood which causes inflammation in the body based on previous research; inflammation increases the risk of atrial fibrillation and heart failure and this study examined the connection between oral hygiene and occurrence of these conditions.
161,286 participants between the ages of 40–79 with no history of heart failure or atrial fibrillation who were part of the Korean National Health Insurance System were enrolled in this study; participants had a routine medical exam between 2003–2004 and information on weight, height, lifestyle, illnesses, lab tests, oral health, and oral hygiene behaviors was collected.
Blueberries are more than just delicious, these little functional foods have been subject to many studies, and now they have been found to have another beneficial ability attributed to their antioxidant rich portfolio, that is the ability to help reduce the risk of heart disease according to a study published in The American Journal of Clinical Nutrition.
This study found that daily consumption one one cup of blueberries over the course of six months resulted in improved arterial function and cholesterol levels in adults with metabolic syndrome. 138 overweight and obese adults aged 50+ with metabolic syndrome were involved in the double blinded and placebo controlled parallel study.
Metabolic syndrome is a term for a cluster of conditions that includes high blood sugar, high triglycerides, and high blood pressure as well as increasing the risk of developing heart disease and Type 2 diabetes.
Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging. Thanks to LastPass for sponsoring this video. Click here to start using LastPass: https://ve42.co/VeLP
What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions — they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.
To counter this decline, we can activate the body’s own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.
Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.
Special thanks to: Professor David Sinclair, check out his book “Lifespan: Why We Age & Why We Don’t Have To“ Assistant Professor David Gold Noemie Sierra (for polyp images) Genepool Productions for telomere animations from Immortal: https://ve42.co/immortal Epigenetics animations (DNA, histones, methylation etc) courtesy of: http://wehi.tv Animation: Etsuko Uno Art and Technical Direction: Drew Berry Sound Design: Francois Tetaz & Emma Bortignon Scientific Consultation: Marnie Blewitt Courtesy of Walter and Eliza Hall Institute of Medical Research.
Filming, editing and animation by Jonny Hyman and Derek Muller.
Columbia scientists have captured the first images of a new gene editing tool that could improve upon existing CRISPR-based tools. The team developed the tool, called INTEGRATE, after discovering a unique “jumping gene” in Vibrio cholerae bacteria that could insert large genetic payloads in the genome without introducing DNA breaks.
In the new study, published today in Nature, the researchers harnessed a Nobel Prize-winning technique called cryo-electron microscopy to freeze the gene editing complex in action, revealing high-resolution details about how it works.
“We showed in our first study how to leverage INTEGRATE for targeted DNA insertions in bacterial cells,” says Sam Sternberg, Ph.D., assistant professor of biochemistry & molecular biophysics at Columbia University Vagelos College of Physicians and Surgeons, who led the research with Israel Fernandez, Ph.D., assistant professor of biochemistry & molecular biophysics at Columbia. “These new images, a wonderful collaboration with Israel Fernández’s lab, explain the biology with incredible molecular detail and will help us improve the system by guiding protein engineering efforts.”
In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route—catastrophic macropinocytosis.
In mouse xenograft studies, the inhibitor acted synergistically with a common chemotherapy drug, cyclophosphamide, to reduce tumor growth. Thus macropinocytosis, a rarely described form of cell death, may aid in the treatment of cancer.
“Understanding the signaling pathways underlying macropinocytosis-associated cell death is an important step in developing additional effective strategies to treat neoplasms that are resistant to apoptosis induced by chemotherapy,” said Mohammad Athar, Ph.D., professor in the University of Alabama at Birmingham Department of Dermatology.
Researchers at the University of Helsinki have discovered a novel system to generate an artificially enveloped oncolytic adenovirus to direct the immune response against cancer.
Virus-based cancer vaccines are nowadays considered an interesting approach in the field of cancer immunotherapy. Targeting tumor-associated antigens is proven to be effective. However, the identification of these antigens remains challenging.
Researchers at the Faculty of Pharmacy, Manlio Fusciello, from the research group led by Professor Vincenzo Cerullo, and Dr. Flavia Fontana, from the research group led by Professor Hélder Santos, and their co-workers, have developed ExtraCRAd, a novel cancer vaccine platform, consisting of an oncolytic adenovirus wrapped in an artificial envelope made of cancer-cell membrane. Oncolytic virus therapy uses modified viruses that can infect and destroy tumor cells but don’t harm normal cells.
Inhale flu viruses after vaccination, and the body responds with an explosion of flu-fighting antibodies, courtesy of a deep-seated memory in the immune system, a response scientists are now finding relies heavily on a complex biological conversation—” crosstalk” between the immune and central nervous systems.
A new investigation underway at the Feinstein Institutes for Medical Research in New York is revealing an interdependence between the immune and nervous system responses to any form of immunization. It has long been known that mammals store memories in the nervous and immune systems. Asking whether the two systems worked together in response to infiltrators—foreign antigens—marks a new line of scientific inquiry.
In their investigation, Feinstein researchers led by Dr. Kevin Tracey have found that antibody responses to immunization require sensory neurons. The research is posted on bioRxiv (pronounced “bio-archive”), a compilation of prepublished studies in the biological sciences.
A computational model could improve the selection of tumor antigens for personalized cancer vaccines that are now in early-stage clinical trials.
Every cell in the human body is coated with fragments of proteins called antigens that tell the immune system what’s inside the cell. Antigens presented on cells that are infected by foreign invaders or have become rogue cancers prompt an immune attack. Such antigens are often used in vaccines to spur immune responses against, for example, viruses like the flu. But to make vaccines that effectively stimulate attack against cancer, researchers need to predict exactly which tumor-specific antigens will be displayed on tumor cells and hence would be the best ones to put in a cancer vaccine.
Now, scientists at the Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute, and Massachusetts General Hospital have developed a new computational tool that could help with this task. The researchers turned to machine learning to analyze a diverse set of more than 185,000 human antigens that they discovered, and generated a new set of rules that predict which antigens are presented on the surface of a person’s cells. The findings, published today in Nature Biotechnology, could aid in the development of new treatments that stimulate the immune system to attack cancer as well as viruses and bacteria.
Hayley Harrison is on a constant Roll… Here she sent me privately this video of the great Bill Faloon… I have not completed the video as yet… But the beginning is awesome I will watch late tonight during my down time… Great Respect to Life Extension and Bill Faloon and Neal Francis Vanderee two of the Longevity Movements most interesting characters and the movements many activists such as Hayley “the watchful” Harrison… AEWR.
My mission is to drastically improve your life by helping you break bad habits, build and keep new healthy habits to make you the best version of yourself.
This video is my interview of longevity pioneer Bill Faloon on December 17, 2019.
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