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Category: biotech/medical – Page 2,090

FDA Approval Granted for Simplified Ventilator Design From Particle Physics Community

In a little over a month, a team of physicists and engineers from around the world took a simplified ventilator design from concept all the way through approval by the U.S. Food and Drug Administration. This major milestone marks the ventilator as safe for use in the United States under the FDA’s Emergency Use Authorization, which helps support public health during a crisis.

The Mechanical Ventilator Milano, or MVM, is the brainchild of physicist Cristiano Galbiati. The Gran Sasso Science Institute and Princeton University professor, who normally leads a dark matter experiment in Italy called DarkSide-20k, found himself in lockdown in Milan, a city hit hard by COVID-19. Hearing reports of ventilator shortages and wanting to help, Galbiati reached out to fellow researchers to develop a ventilator with minimal components that could be quickly produced using commonly available parts.

“The sense of crisis was palpable, and I knew the availability of ventilators was critical,” said Galbiati, who obtained his Ph.D from the University of Milan. “We had been doing some complicated projects in physics that required working with gases, and I thought it our duty to find a way to push oxygen into the lungs of patients.”

‘Cutting edge’ ventilator enters race to beat coronavirus

A “cutting edge” alternative ventilator for coronavirus patients has been developed by a taskforce. The ‘exovent’ is a reinvention of the traditional iron lung, which saved the lives of countless polio victims during the 20th century.

Unlike the usual ventilators, which are positive pressure ventilators (PPV), the exovent is a non-invasive negative pressure ventilation (NPV) device, which could be used both in intensive care or on an ordinary hospital ward.

www.cambridge-news.co.uk/…/cambridge-coronavirus-ventillato…

Developed by a task force including Cambridge-based Marshall Aerospace and Defence Group, it can be manufactured in parallel with other ventilator designs.

Study suggests polymer composite could serve as lighter, non-toxic radiation shielding

A new study from researchers at North Carolina State University suggests that a material consisting of a polymer compound embedded with bismuth trioxide particles holds tremendous potential for replacing conventional radiation shielding materials, such as lead.

The trioxide compound is lightweight, effective at shielding against ionizing radiation such as , and can be manufactured quickly—making it a promising material for use in applications such as , medical imaging and .

“Traditional radiation shielding materials, like lead, are often expensive, heavy and toxic to human health and the environment,” says Ge Yang, an assistant professor of nuclear engineering at NC State and corresponding author of a paper on the work. “This proof-of-concept study shows that a bismuth trioxide compound could serve as effective radiation shielding, while mitigating the drawbacks associated with traditional shielding materials.”

Neuroplasticity In Action

Neuroplasticity is the brain’s ability to change under the influence of experience and activities. Several aspects of neuroplasticity are noteworthy: neurogenesis (development of new nerve cells) and synaptogenesis (development of new contacts between nerve cells) among them. Neuroplasticity used to be thought of as a limited phenomenon, mostly restricted to the early years of life. More recently it has been demonstrated that neuroplasticity continues throughout life, even in advanced age. This provides the conceptual basis for a wide range of therapeutic efforts aiming to slow the detrimental effects of aging on the brain and to treat various brain disorders.

What are the factors influencing neuroplasticity? The question is compelling both as a scientific challenge and because of the therapeutic promise of neuroplasticity once we know how to control and harness it. Among such factors, the environmental factors influencing neuroplasticity are particularly intriguing. It turns out that a strong relationship exists between what people do with their brains and how their brains age.

Both anecdotal observations and formal research suggest that education confers a protective effect against dementia. Highly educated people are less likely to succumb to its effects. Robert Katzman was the first to note that the prevalence of dementia, including Alzheimer’s disease, is lower in people with advanced education. The MacArthur Foundation Research Network on Successful Aging sponsored a study of the predictors of cognitive change in older persons. Education emerged as by far the most powerful predictor of cognitive vigor in old age.

Secretive Jasons to offer advice on how to reopen academic labs shut

‘s COVID-19 reporting is supported by the Pulitzer Center.

A group of prominent academic scientists that has been advising the U.S. government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security—the impact of COVID-19 on academic research. And this time it’s personal.

Last month, some 30 members of Jason began to tackle the thorny question of how to reopen university laboratories safely in the midst of the coronavirus pandemic. Nobody is paying for the study, a rare departure for the group, whose work is usually financed by government agencies and often involves classified information. But the study’s leader, Massachusetts Institute of Technology (MIT) physicist Peter Fisher, says several federal agencies have expressed interest in the group’s analysis of the technical challenges facing every university that wants to resume research operations without jeopardizing the health of the faculty, students, and staff who work in those labs.

How to boost plant biomass: Biologists uncover molecular link between nutrient availability, growth

Plant scientists have long known that crop yield is proportional to the dose of nitrogen fertilizer, but the increased use of fertilizers is costly and harmful to the environment. Until now, the underlying mechanisms by which plants adjust their growth according to the nitrogen dose has been unknown—a key finding that could help enhance plant growth and limit fertilizer use.

In a new study published in the Proceedings of the National Academy of Sciences (PNAS), plant genomic scientists at New York University’s Center for Genomics & Systems Biology discovered the missing piece in the molecular link between a plant’s perception of the nitrogen dose in its environment and the dose-responsive changes in its biomass.

Taking a novel approach, the NYU researchers examined how increasing doses of nitrogen created changes in ’ genome-wide expression as a function of time. They then used mathematical models to investigate the rate of change of messenger RNA (mRNA) for thousands of genes within the genome to this experimental set up.

Blood Factors Reverse Epigenetic Age

Crucially, plasma treatment of the old rats reduced the epigenetic ages of blood, liver and heart by a very large and significant margin, to levels that are comparable with the young rats. According to the six epigenetic clocks, the plasma fraction treatment rejuvenated liver by 73.4%, blood by 52%, heart by 52%, and hypothalamus by 11%. The rejuvenation effects are even more pronounced if we use the final versions of our epigenetic clocks: liver 75%, blood 66%, heart 57%, hypothalamus 19%. According to the final version of the epigenetic clocks, the average rejuvenation across four tissues was 54.2%.

Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood.

Epigenetic changes

One of the proposed reasons we age are the changes to gene expression that our cells experience as we get older; these are commonly called epigenetic alterations. These alterations harm the fundamental functions of our cells and can increase the risk of cancer and other age-related diseases.

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