Lifeboat Foundation

A woman is already pregnant with the next CRISPR baby, according to He Jiankui, the Chinese scientist who claims to have already created the world’s first genetically edited babies.

Bombshell: He made the claim about the early-stage pregnancy on the second day of an international gene-editing summit at the University of Hong Kong. “There is another one, another potential pregnancy,” he said on stage. He defended his work, saying he feels “proud” to have used gene-editing techniques to make the twin girls HIV resistant. “This is not just for this case, but for millions of children. They need this protection. [An] HIV vaccine is not available,” he said.

Irresponsible: After his presentation, He was quizzed by audience members about his work. Nobel laureate David Baltimore said that proceeding with germ-line editing in this way was “irresponsible” and criticized He for not being more open. “I think there has been a failure of self-regulation by the scientific community because of the lack of transparency,” he said. It also emerged that none of He’s presentation slides had contained information about the implanted embryos—or the babies—when they were submitted to the conference organizers.

Continue reading “A second CRISPR pregnancy is already under way, claims Chinese scientist” »

Antibiotics have emerged as potentially lifespan-enhancing drugs, according to the results of new research carried out in the UK.

Genetic experiments that eliminate “senescent” cells – older cells, which lose the ability to divide – have already been proven to alleviate age-related dysfunction in model organisms.

Now, scientists have shown for the first time that an FDA-approved antibiotic – Azithromycin – can effectively target and eliminate senescent cells in culture.

Continue reading “Antibiotics eliminate senescent cells associated with ageing” »

Giulio Prisco ‘s key point: “My first reaction to Satoshi’s white paper was like, here’s a possibly viable implementation of an internet currency independent of nation states, which can be used for online payments with strong privacy. My current description of bitcoin is exactly the same.”

Forget the ongoing bitcoin crash. Forget that you lost 80 percent of your crypto wealth since Christmas last year. If you HODL, Crypto Santa will make you filthy rich by Christmas next year.

The world’s most famous genetic tool has a major diversity problem.

It appears that researchers in China have facilitated the birth of the first “designer baby” – actually babies, twin girls who are supposedly genetically resistant to HIV.

The scientist who created the embryos, as well as some American scientists like Harvard’s George Church, have praised the beneficent intent to producing a child who is resistant to disease.

Who could argue with such good intentions?

Continue reading “A Scientist Explains Why The Alleged CRISPR Babies News Is More Shocking Than You Might Realise” »

Harvard University geneticist George Church says reaction to experiments has been “extreme”.

PANC-1 human pancreatic cancer cells are characterized by their ability to proliferate aggressively under hypovascular and hypoxic conditions in the tumor microenvironment, displaying a remarkable tolerance to nutrition starvation. The antiausterity strategy is a new approach in anticancer drug discovery aiming at the identification of potent agents that inhibit preferentially the survival of tumor cells during a limited supply of nutrients and oxygen. The new 5,8′-coupled naphthyldihydroisoquinoline alkaloid ancistrolikokine E₃ (4), isolated from the Congolese liana Ancistrocladus likoko, showed potent preferential cytotoxicity against PANC-1 cells under nutrient-deprived conditions, with a PC₅₀ value of 2.5 μM, without exhibiting toxicity in normal, nutrient-rich medium. The compound was found to induce dramatic alterations in cell morphology, leading to cell death. Moreover, it inhibited significantly PANC-1 cell migration and colony formation in a concentration-dependent manner. This study on 4 provides the first live evidence of the effect of a naphthyldihydroisoquinoline alkaloid against PANC-1 cells in nutrient-deprived medium. Mechanistic investigations conducted suggest that compound 4 is a potent inhibitor of the activation of the Akt/mTOR pathway. Furthermore, it inhibited the expression levels of the key autophagy regulators Atg5, Atg12, Beclin-1, LC3-I, and LC3-II. The results demonstrated that ancistrolikokine E₃ (4) is a potent early-stage inhibitor of the autophagy pathway in PANC-1 human pancreatic cancer cells. Ancistrolikokine E₃ (4) and related naphthylisoquinoline alkaloids are promising potential lead compounds for anticancer drug development based on the antiausterity strategy.

Cryoablation — the destruction of cancer cells through freezing — shows early indications of effectiveness in treating women with low-risk breast cancers, according to research being presented today at the annual meeting of the Radiological Society of North America (RSNA). Researchers said that over the four years of the study, there has only been one case of cancer recurrence out of 180 patients.

3D bioprinting continues to diversify as more and more companies and research organizations join the field, each bringing their own take on the technology to the table. French collaborative platform 3D.fab has an intriguing approach towards bioprinting that involves a freeform robot capable of directly printing on a part of the body. In the video below, the BioAssemblyBot prints what appears to be a bandage directly on an arm:

Continue reading “3D.fab’s BioAssemblyBot Wants to 3D Print Skin onto People” »