Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1,915

Few recognize the vast implications of materials science.

To build today’s smartphone in the 1980s, it would cost about $110 million, require nearly 200 kilowatts of energy (compared to 2kW per year today), and the device would be 14 meters tall, according to Applied Materials CTO Omkaram Nalamasu.

That’s the power of materials advances. Materials science has democratized smartphones, bringing the technology to the pockets of over 3.5 billion people. But far beyond devices and circuitry, materials science stands at the center of innumerable breakthroughs across energy, future cities, transit, and medicine. And at the forefront of Covid-19, materials scientists are forging ahead with biomaterials, nanotechnology, and other materials research to accelerate a solution.

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Memory is the natural extension of attention and learning. The act of memory facilitates the formation, activation, and retention of circuits that contribute to the brain’s optimal functioning. Dr. Restak explains how we are the sum total of the memory we retain. Without memory, we wouldn’t know who we are.

The hippocampus, a portion of the brain located in the temporal lobe of each cerebral cortex, is the entry portal for information to be remembered. If the hippocampus is damaged, we have difficulty forming new memories.

This was demonstrated by Patient H. M., whose real name was Henry Molaison. He started having seizures when he was 10 years old. By age 20, he was completely incapacitated.

Since he could be felled with one of the sudden seizures at any time, he couldn’t work or form relationships, and lived at home with his mother. At age 27, in 1953, he underwent a new type of operation.

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A new weapon in the arsenal against the coronavirus may be sitting in your home entertainment console. A team led by physicist Chris Barty of the University of California, Irvine is researching the use of diodes from Blu-ray digital video disc devices as deep-ultraviolet laser photon sources to rapidly disinfect surfaces and the indoor air that swirls around us.

Barty, UC Irvine distinguished professor of physics & astronomy, said that such UV light sterilizers would be cheap compared to current medical- and scientific-grade systems and that it’d be possible to deploy them almost anywhere.

“If these sources are successful, I think you could build them into a mask and clean the air that’s coming in and out of you,” he said. “Or you could set these things up in the air circulation ducts of major buildings, and the airflow that goes through could be sterilized.”

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More than 100 teams around the world are racing to develop a coronavirus vaccine. Dr. Ofer Levy and a group of Harvard Medical School researchers are among them, but the vaccine they’re working on is a little different. It’s specifically designed for those most vulnerable to the disease: the elderly.

“Most vaccines are developed with a one-size-fits-all concept,” Levy told Business Insider. “Academic centers and companies typically develop a vaccine assuming that you will respond to the vaccine the same way, whether you’re a man or a woman, whether you’re young or elderly, whether you live in the US or Africa, whether you give the vaccine in the summer or winter, whether you give it in the morning or the evening.”

Vaccines generally aren’t as effective for the elderly. A Harvard lab is working on a COVID-19 vaccine that would be most effective for them.

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Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with non-cytotoxic compounds is poorly understood. Here we show that vitamin C anticancer activity is limited by the up-regulation of the stress-inducible protein heme-oxygenase-1. The fasting-mimicking diet selectivity reverses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cells, consequently increasing reactive iron, oxygen species, and cell death; an effect further potentiated by chemotherapy. In support of a potential role of ferritin in colorectal cancer progression, an analysis of The Cancer Genome Atlas Database indicates that KRAS mutated colorectal cancer patients with low intratumor ferritin mRNA levels display longer 3- and 5-year overall survival. Collectively, our data indicate that the combination of a fasting-mimicking diet and vitamin C represents a promising low toxicity intervention to be tested in randomized clinical trials against colorectal cancer and possibly other KRAS mutated tumors.

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Three critically ill patients at Baptist Hospital in Miami were the first in the U.S. to be successfully treated with stem cells.

The patients were suffering from acute respiratory distress syndrome, or ARDS, and doctors infused them intravenously with cells derived from the lining of umbilical cords.

These are called mesenchymal stem cells and within days after the infusion, the patients who needed 100% oxygen on ventilator support, saw their requirement slashed in half. This significant reduction was also accompanied by a drop in inflammatory markers, meaning that the harmful inflammation crippling the lungs was not only arrested but reversed, according to Baptist Health South

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DNA damage is common to our cells, but when we’re young our bodies can fix it pretty easily. Unfortunately we lose that ability over time, leading to many of the symptoms of aging that we know all too well. A new study from MIT has found that reactivating a certain enzyme improves repair of DNA damage in neurons, which helps Alzheimer’s patients and others with cognitive decline.

Previous studies by the team have shown that an enzyme called HDAC1 seems to be involved in DNA repair in neurons. For the new study, the researchers examined what happens when HDAC1 doesn’t do its job.

The team engineered mice to be deficient in HDAC1, and monitored their health compared to normal mice. Things looked good during the animals’ youth – there were no differences in DNA damage or behavior between the two groups. But as they aged, the decline became clear.

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If you’re interested in superlongevity and superintelligence, then I have a book to recommend., by Sonia Contera, is a book about the intersection of biotech and nanotech. Interesting and well written for the layman, the book covers some of the latest developments in nanotechnology as it applies to biological matters. Although there are many topics, I was primarily interested in the DNA nanobots, DNA origami, and the protein nanotechnology sections. My interest is piqued in these arenas due to my expectation that DNA nanobots and protein nanobots, as well as complex self-assembled custom nanostructures, are going to be key to some of the longevity technologies and some of the possible substrates for mind uploading that are key to superlongevity and superintelligence. There are also sections in the book on 3D bioprinted organs — progress and possibilities, as well as difficulties.

There is even a section that clearly was written specifically to address a discussion that has engaged my friends, Dinorah Delfin and Dan Faggella. The title is:

FUTURE DEVICES: QUANTUM PHYSICS MEETS BIOLOGY MEETS NANOTECHNOLOGY

Now, some might be tempted to consider that particular combination to be “woo woo”, however, please keep in mind the author’s credentials. Sonia Contera is a professor of biological physics in the Department of Physics at the University of Oxford.

Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology, advances in nanoscience and technology are transforming how people think about life and treat human health.

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