Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1,900

It’s hard to piece together the full history of human evolution from piles of old bones. But now, scientists have made use of a new method to study proteins in dental enamel of an 800,000-year-old human species, helping place it in the family tree.

Although Homo sapiens is the only human species still alive today, the road to get here is paved with extinct relatives. And untangling how they’re all related to each other is a task that scientists continue to wrestle with. The timeline is usually determined through various dating processes, both on the bones themselves and the sediment layers they’re found in. Relationships between species are then determined from this timeline, and by examining the structures and features of the bones to track the progress of evolution.

For the new study, researchers at the University of Copenhagen have used a new tool called palaeoproteomics to get a more precise picture. This involves sequencing proteins from ancient remains, and it works on samples that are far too old to have intact DNA. In this case, the team applied it to the 800,000-year-old teeth of a mysterious, archaic human species called Homo antecessor.

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Could used for anything to reduce size just like an ant man suit :3.

Scientists can put all kinds of useful materials in the polymer before they shrink it such as metals, quantum dots and DNA. Pictured is the machine used to shrink objects.

The polyacrylate forms the scaffold over which other materials can be attached.

It is then bathed in a solution that contains molecules of fluorescein, which attach to the scaffold when they are activated by laser light.

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Dr. Derek Yach, Founder, President, and Board Member of The Foundation for a Smoke-Free World (FSFW), joined me on ideaXme (http://radioideaxme.com/) to discuss his group’s work in the core areas of Agriculture and Livelihoods, Industry Transformation, and Health, Science, and Technology (Disclosure — FSFW is funded ~$US1 Billion by Philip Morris International, but take a listen to full story…) — #Ideaxme #Smoking #Vaping #Tobacco #Cessation #AlternativeUses #HarmReduction #WHO #CDC #Health #Wellness #Longevity #Biotechnology #LifeExtension #Aging #IraPastor #Bioquark #Regenerage World Health Organization (WHO) CDC CDC Global United Nations Philip Morris International.

Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Dr. Derek Yach, founder, president, and board member of The Foundation for a Smoke-Free World, and passionate advocate for health promotion and disease prevention. Dr Yach’s objective is to end smoking in this generation. We investigated to see how that might be achieved.

Disclosure: The Foundation for a Smoke-Free World has received its initial funding pledge of $80 million USD annually for 12 years, beginning in 2018 from Philip Morris International (PMI) — The Foundation has a nonprofit status as a US 501c3 organization, and by law and policy must operate completely independently from PMI, and cannot engage in activities designed to support PMI’s interests. Further, PMI can have no involvement or say in their work.

Ira Pastor Comments:

The World Health Organization (WHO) estimates that we currently have over 1.1 billion smokers on earth, and that tobacco kills more than 8 million people each year. More than 7 million of those deaths are the result of direct tobacco use while around 1.2 million are the result of non-smokers being exposed to second-hand smoke.

Continue reading “ENDING SMOKING In This Generation” | >

Research involving bowhead whales has suggested that it may one day be possible to extend the human lifespan to 200 years.

From the demigods of Greek mythology to the superheroes of 20th century comic books, we’ve been intrigued by the idea of human enhancement for quite a while, but we’ve also worried about negative consequences. Both in the Greek myths and modern comics and television, each enhanced human has been flawed in some way.

In the area of lifespan enhancement, for instance, Tithonus, though granted eternal life, shrunk and shriveled into a grasshopper, because his immortal girlfriend Eos, forgot to ask Zeus to give him eternal youth. Achilles, while super strong and agile, had a weak spot at the back of his heal, and Superman would lose his power if exposed to “kryptonite”. As for Khan’s people, their physical superiority, both physical and mental, made them overly ambitious, causing a third world war that nearly destroyed humanity in the Star Trek backstory.

Using genetic modification, nanotechnology, bionics, reconstructive surgery, hormones, drugs or any combination of these approaches, real-life human enhancement is looking ever more achievable. As with the fictional examples, the idea of enhancement being a double-edged sword will surely remain part of the discussion. At the same time, though, because enhancement means mastering and manipulating human physiology and the basis of consciousness and self-awareness, the road to enhancement will be paved with advances beneficial to the sick and the disabled. This point must be at center stage when we weigh the pluses and minuses in various enhancement categories, especially physical capability, mental function, and lifespan.

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We have the technology to potentially add a 47th chromosome, to compound as it were, a new human entity. The implications are enormously consequential.

C.S. Lewis warned about our final mastery over nature, and the inevitable drift into a future world where knowledge about the old world completely vanishes, where what once was, irretrievably transforms into something else:

… We do not look at trees either as Dryads or as beautiful objects while we cut them into beams: The first man who did so may have felt the price keenly, and the bleeding trees in Virgil and Spenser may be far-off echoes of that primeval sense of impiety … The great minds know very well that the object, so treated, is an artificial abstraction, that something of its reality has been lost.[1]

I say with confidence that I can’t swim the Pacific, but for a whale, it’s possible. Like whales, to the extent we can exploit the full measure of our form, we may insure the survival of those that follow in our wake.[2] But, what happens when “form” transforms a species, not in response to Darwinian adaptation, but by design? Does it improve its sustainability or work at cross purposes, perhaps creating another species?1 About 32,000 years ago, canines were probably the first animals altered by humans. Bully for us, we tamed the wolf. In some cases hybridization changes the number of chromosomes carried by the crossbreed. The mule for example has 63 versus 64 carried by the dam (female horse parent) and 62 carried by the sire (male donkey parent).2 The different structure and number renders mules superior to horses or donkeys in some respects, but brings with it infertility.

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:oooo.

Precision oncology relies on accurate discovery and interpretation of genomic variants, enabling individualized diagnosis, prognosis and therapy selection. We found that six prominent somatic cancer variant knowledgebases were highly disparate in content, structure and supporting primary literature, impeding consensus when evaluating variants and their relevance in a clinical setting. We developed a framework for harmonizing variant interpretations to produce a meta-knowledgebase of 12,856 aggregate interpretations. We demonstrated large gains in overlap between resources across variants, diseases and drugs as a result of this harmonization. We subsequently demonstrated improved matching between a patient cohort and harmonized interpretations of potential clinical significance, observing an increase from an average of 33% per individual knowledgebase to 57% in aggregate. Our analyses illuminate the need for open, interoperable sharing of variant interpretation data. We also provide a freely available web interface (search.cancervariants.org) for exploring the harmonized interpretations from these six knowledgebases.

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