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Category: biotech/medical – Page 1,802

“It seems like they may be onto something,” Dr. Valery Fitzhugh, a Rutgers University pathologist who didn’t work on the study, told the NYT. “If it’s real, it could change the way we look at disease in this region.”

The fourth pair of salivary glands are better hidden than the other three, which are right beneath our skin and can be manipulated through the surface. So unless doctors were explicitly looking for them, it’s feasible to see how the easily-damaged glands went undiscovered all this time.

“The location is not very accessible, and you need very sensitive imaging to detect it,” study author Dr. Wouter Vougel, a radiation oncologist at the Netherlands Cancer Center, told the NYT.

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Imagine a mobile phone charger that doesn’t need a wireless or mains power source. Or a pacemaker with inbuilt organic energy sources within the human body.

Australian researchers led by Flinders University are picking up the challenge of “scavenging” invisible power from low-frequency vibrations in the surrounding environment, including wind, air or even contact-separation energy (static electricity).

“These so-called triboelectric nanogenerators (or TENGs) can be made at low cost in different configurations, making them suitable for driving such as personal electronics (mobile phones), biomechanics devices (pacemakers), sensors (temperature/pressure/chemical sensors), and more,” says Professor Youhong Tang, from Flinders University’s College of Science and Engineering.

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Just like humans, microbes have equipped themselves with tools to recognize and defend themselves against viral invaders. In a continual evolutionary battle between virus and host, CRISPR-Cas act as a major driving force of strain diversity in host-virus systems.

A new study led by Professor of Life Sciences Shai Pilosof (Ben-Gurion University of the Negev, Beer-Sheva, Israel), Professor of Microbiology Rachel Whitaker (University of Illinois Urbana-Champaign), and Professor of Ecology and Evolution Mercedes Pascual (University of Chicago) highlights the role of diversified immunity in mediating -pathogen interactions and its eco-evolutionary dynamics. The study also included Professor of Bioengineering and Bliss Faculty Scholar Sergei Maslov (University of Illinois Urbana-Champaign), Sergio A. Alcal´a-Corona (University of Chicago), and Ph.D. graduate students Ted Kim and Tong Wang (University of Illinois Urbana-Champaign).

Their findings were reported in the journal Nature Ecology & Evolution.

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Portable sequencing is making it possible for biologists to perform DNA analysis anywhere in the world. How is this technology reshaping the way they work?

Thanks to nanopore technology, scientists can now collect samples and sequence them anywhere. It is the concept of backpacking applied to scientific research.

French molecular biologist Anne-Lise Ducluzeau has experienced this first hand during her research in the freezing environment of Alaska. “I remember driving back home with my sequencing station on the passenger seat, it was −20ºF (−29ºC) but the car was warm and reads kept coming,” ‪relates Ducluzeau, who has been using a portable sequencer for her research for the past four years.

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Knowing which proteins are key to protection from disease, and the deficiencies in expression or activity that are hallmarks of disease, can inform individualized medicine and the development of new therapies.

Twenty years after the release of the human genome, the genetic “blueprint” of human life, an international research team, including the University of British Columbia’s Chris Overall, has now mapped the first draft sequence of the human proteome.

Their work was published Oct. 16 in Nature Communications and announced today by the Human Proteome Organization (HUPO).

“Today marks a in our overall understanding of human life,” says Overall, a professor in the faculty of dentistry and a member of the Centre for Blood Research at UBC. “Whereas the provides a complete ‘blueprint’ of , the human proteome identifies the individual building blocks of life encoded by this blueprint: proteins. ” Proteins interact to shape everything from life-threatening diseases to cellular structure in our bodies.”

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A team of New York University scientists has developed a method using holographic imaging to detect both viruses and antibodies. The breakthrough has the potential to aid in medical diagnoses and, specifically, those related to the COVID-19 pandemic.

“Our approach is based on physical principles that have not previously been used for diagnostic testing,” explains David Grier, a professor of physics at NYU and one of the researchers on the project, which is reported in the journal Soft Matter. “We can detect and viruses by literally watching them stick to specially prepared test beads.”

If fully realized, this proposed test could be done in under 30 minutes, is highly accurate, and can be performed by minimally trained personnel. Moreover, the method can test for either the (current infection) or antibodies (immunity).

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Pfizer has already made “several hundred thousand doses” of a potential coronavirus vaccine as it prepares to seek emergency use in the US by November.

The drugmaker told the Mail on Sunday that scientists in its main British lab have also unearthed drugs that could provide a potential complete cure for COVID-19, as opposed to merely a preventative vaccine.

The firm’s UK boss, Ben Osborn, said the company is manufacturing the huge stockpile of its current vaccine candidate in Belgium “at risk and at scale,” calling it “tremendously exciting.”

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Article. The research/article indicates that childhood trauma can not only impact the current generation, but future generations. Biochemical signals are sent to the germ cells, modifying the expression of some genes and/or the DNA structure.

Traumatic experiences can have a lasting impact, so children that suffer through them can feel their effects for a lifetime. Work has also shown that trauma can change the way genes are expressed, through epigenetics. Epigenetic changes do not alter the sequence of genes but they alter the biochemistry of DNA, and these changes are sometimes passed down to future generations through germ cells. Scientists have been working to learn more about how traumatic events get embedded in the genetic code of germ cells.

Image credit: Pkist

New research reported in The EMBO Journal has used a mouse model to suggest that childhood trauma can influence the composition of blood, and this is the conduit for passing the impact down to offspring.

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“In a world first, a “cold-shock” protein has been found in the blood of regular winter swimmers at London’s Parliament Hill Lido.”

“The protein has been shown to slow the onset of dementia and even repair some of the damage it causes in mice.”

“Prof Giovanna Mallucci, who runs the UK Dementia Research Institute’s Centre at the University of Cambridge, says the discovery could point researchers towards new drug treatments which may help hold dementia at bay.”

Swimmers at a London lido aid understanding of what cold does to the body.

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