Lifeboat Foundation

Electric generators have a plethora of uses—ranging from automotive to aircraft to microgrids. There is currently a strong desire to reduce the size and increase the efficiency of the devices.

Researchers at Purdue University have come up with an effective way to reduce the size and increase the efficiency of the moderate- to low-power electric generators used in those applications.

A wound rotor synchronous machine contains a field winding—a group of insulated current-carrying coils—on the rotor used to create a rotating magnetic field and regulate the output voltage. Associated with this winding are losses, which generate heat that must be removed from the spinning rotor. Permanent magnets can also be used to generate the magnetic field with much less loss and heat generation, but this approach does not facilitate output voltage regulation.

A machine that speeds up evolution is revolutionizing genome design and selection of designer microbes.

For 50 years, evolutionary theory has emphasized the importance of neutral mutations over adaptive ones in DNA. Real genomic data challenge that assumption.

How can bee stings help in the battle against HIV? Could snake venom be used to treat high blood pressure? Kath Nightingale investigates.

The loss of complete segments of the esophagus often results from treatments for esophageal cancer or congenital abnormalities, and current methods to re-establish continuity are inadequate. Now, working with a rat model, researchers have developed a promising reconstruction method based on the use of 3D-printed esophageal grafts. Their work is published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Eun-Jae Chung, MD, PhD, Seoul National University Hospital, Korea, Jung-Woog Shin, PhD, Inje University, Korea, and colleagues present their research in an article titled “Tissue-Engineered Esophagus via Bioreactor Cultivation for Circumferential Esophageal Reconstruction”. The authors created a two-layered tubular scaffold with an electrospun nanofiber inner layer and 3D-printed strands in the outer layer. After seeding human mesenchymal stem cells on the inner layer, constructs were cultured in a bioreactor, and a new surgical technique was used for implantation, including the placement of a thyroid gland flap over the scaffold. Efficacy was compared with omentum-cultured scaffolding technology, and successful implantation and esophageal reconstruction were achieved based on several metrics.

Dr. Chung and colleagues from Korea present an exciting approach for esophageal repair using a combined 3D printing and bioreactor cultivation strategy. Critically, their work shows integration of the engineered esophageal tissue with host tissue, indicating a clinically viable strategy for circumferential esophageal reconstruction.”

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With that basic research, mankind found the first major clue to the origins of aging and death. They discovered that some cells in our bodies that may never die. These “immortal cells” and the philosophical shift in thinking they engendered, will likely change medicine as we know it.

Different African killifish species vary extensively in their lifespans—from just a few months to several years. Scientists from the Max Planck Institute for Biology of Ageing in Cologne investigated how different lifespans have evolved in nature and discovered a fundamental mechanism by which detrimental mutations accumulate in the genome causing fish to age fast and become short-lived. In humans, mutations accumulate mainly in the genes that are active in old age.

Russian biologist Denis Rebrikov plans to help five couples who are deaf try CRISPR gene-editing to avoid having a child that inherits the condition.