Binary Defense researchers have identified a bug in the Emotet malware and have been using it to prevent the malware from making new victims.
Category: biotech/medical – Page 1,778
New research into malaria suggests targeting enzymes from the human host, rather than from the pathogen itself, could offer effective treatment for a range of infectious diseases, including COVID-19.
WASHINGTON (Reuters) — Chinese government-linked hackers targeted biotech company Moderna Inc, a U.S.-based coronavirus vaccine research developer, this year in a bid to steal data, according to a U.S. security official tracking Chinese hacking.
China on Friday rejected the accusation that hackers linked to it had targeted Moderna.
Last week, the U.S. Justice Department made public an indictment of two Chinese nationals accused of spying on the United States, including three unnamed U.S.-based targets involved in medical research to fight the novel coronavirus.
Antibiotic resistance is an increasing health problem, but new research suggests it is not only caused by the overuse of antibiotics. It’s also caused by pollution.
Using a process known as genomic analysis, University of Georgia scientists found a strong correlation between antibiotic resistance and heavy metal contamination in an environment.
Jesse C. Thomas IV, an alumnus of the College of Public Health and the Savannah River Ecology Laboratory, found commonalities in soils contaminated with heavy metals on the U.S. Department of Energy’s Savannah River Site near Aiken, South Carolina.
The US Food and Drug Administration (FDA) has approved viltolarsen (Viltepso; NS Pharma) for the treatment of patients with Duchenne muscular dystrophy amenable to exon 53 skipping, making it only the second FDA-approved therapy for this specific DMD gene mutation.
The agent from NS Pharma, delivered via weekly intravenous infusion, was granted accelerated approval via its priority review, fast track, orphan drug, and rare disease designations after its new drug application was accepted earlier this year. In March, NS Pharma launched an expanded access program for qualified patients.
The approval was granted based on findings from a phase 2 clinical trial (NCT02740972) and long-term extension study, details of which were recently published in JAMA Neurology. Among 16 participants age 4 to 9, significant drug-induced dystrophin production was observed in both viltolarsen dose cohorts (40 mg/kg per week: mean, 5.7% [range, 3.2–10.3] of normal; 80 mg/kg per week: mean, 5.9% [range, 1.1–14.4] of normal), with 15 (94%) patients achieving dystrophin levels greater than 2% of normal and 14 of 16 (88%) achieving levels greater than 3% of normal.
Eukaryotic DNA Replication
Posted in biotech/medical
This video explains the details of eukaryotes, replication in eukaryotes and differences between prokaryotic DNA replication and eukaryotic DNA replication.
Malak Trabelsi Loeb
13-08-2020
Covid-19 did not only cause a health crisis around the world; It led to severe economic, social, and political challenges in various countries.
In response to the World Health Organization recommendations, governments imposed various precautionary measures in the course of managing its risks. Measures varied from mere social distancing to total lockdown and isolation in quarantine centers.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Currently, several vaccine candidates against SARS-CoV-2 are in clinical trials but approval of these vaccines is likely to take a long time before they are available for public use. In a previous report, the importance of passive immunity and how immunoglobulin (Ig)G collected from recovered coronavirus patients could help in the protection against COVID-19 and boost the immune system of new patients was reported. Passive immunity by immunoglobulin transfer is a concept employed by most mammals and bovine IgG has a role to play in human therapy. IgG is one of the major components of the immunological activity found in cow’s milk and colostrum. Heterologous transfer of passive immunity associated with the consumption of bovine immune milk by humans has been investigated for decades for its immunological activity against infections. This short review focuses on passive immunity and how microfiltered raw immune milk or colostrum collected from cows vaccinated against SARS-CoV-2 could provide short-term protection against SARS-CoV-2 infection in humans and could be used as an option until a vaccine becomes commercially available.
Currently, different academic institutions and pharmaceutical companies worldwide have started programs to develop and test vaccine candidates against SARS-CoV-2 in clinical trials. An S-glycoprotein-based vaccine is a promising approach that has attracted the attention of scientists, since S-glycoprotein can be directly recognized by the host’s immune system. For the first coronavirus (SARS-CoV-1), which was identified in Guangdong province, China, in November 2002, different vaccines were developed and tested in animal models. Some of these vaccines prevented animal infection after challenge with SARS-CoV-1. Kapadia et al. showed that neutralizing antibodies against SARS-CoV-1 could be detected in sera from mice immunized with S-glycoprotein of SARS-CoV-1 (10, 11).
The proposed mechanism of action described in the claim that 5G millimeter waves can generate SARS-CoV-2 in human cells violates fundamental principles of biology. Scientific evidence does not support a causal relationship between 5G and COVID-19. Many of the regions with the highest COVID-19 infection rates, such as Brazil, do not have 5G coverage, providing further evidence that 5G is not associated with the pandemic.
FULL CLAIM: 5G generates coronavirus in human skin cells
Scientists from 4 different Swiss universities describe how adhesion molecules activate autoaggressive immune cells and drive their infiltration in the nervous system in a model of multiple sclerosis.
Click to read the paper published in Frontiers in Immunology: https://fro.ntiers.in/tp1U
In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB) to reach the central nervous system (CNS), where they induce neuroinflammation. Here, we explored the role of intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in the activation of naïve myelin-specific T cells and in the subsequent migration of differentiated encephalitogenic Th1 and Th17 cells across the BBB in vitro and in vivo. While on antigen-presenting cells ICAM-1, but not ICAM-2 was required for the activation of naïve CD4+ T cells, endothelial ICAM-1 and ICAM-2 mediated both Th1 and Th17 cell migration across the BBB. ICAM-1/-2-deficient mice developed ameliorated typical and atypical EAE transferred by encephalitogenic Th1 and Th17 cells, respectively. Our study underscores important yet cell-specific contributions for ICAM-1 and ICAM-2 in EAE pathogenesis.
Multiple sclerosis (MS) is considered an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE), a prototypic animal model for MS, mimics many aspects of the acute inflammatory phase of the human disease (1). In EAE, naïve myelin-reactive CD4+ T cells are activated and differentiated in peripheral lymphoid tissue into encephalitogenic Th1 or Th17 cells, which travel in the blood circulation to the CNS. After crossing the blood-brain barrier (BBB) they next infiltrate in the CNS parenchyma, leading to clinical manifestation of the disease (2). EAE can be actively induced by immunization with CNS myelin antigens emulsified in complete Freund’s adjuvant (aEAE) or by injection of myelin-reactive CD4+ T cells into syngeneic naïve recipients (tEAE) (3, 4).
Activation of naïve CD4+ T cells during aEAE occurs in the draining peripheral lymph nodes (dLNs), where T cells recognize their cognate antigen (Ag) on antigen-presenting cells (APCs) forming periodic contacts between the T-cell receptor (TCR) and the myelin oligodendrocyte glycoprotein (MOG)aa35−55 peptide loaded major histocompatibility complex (pMHC) on the APCs, referred to as the immunological synapse (IS) (5, 6). The fate of naïve T cells is determined within hours after Ag exposure by interacting with APCs in LN. The interaction between the integrin lymphocyte function associated antigen-1 (LFA-1) on the T cells and its ligand intercellular adhesion molecule-1 (ICAM-1) on the APCs is suggested to be involved in modulating the IS. However, APCs additionally express ICAM-2, an alternate ligand of LFA-1.