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Category: biotech/medical – Page 1662

Individual frequency can be used to specifically influence certain areas of the brain and thus the abilities processed in them — solely by electrical stimulation on the scalp, without any surgical intervention. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences have now demonstrated this for the first time.

Stroke, Parkinson’s disease and depression — these medical illnesses have one thing in common: they are caused by changes in brain functions. For a long time, research has therefore been conducted into ways of influencing individual brain functions without surgery in order to compensate for these conditions.

Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have taken a decisive step. They have succeeded in precisely influencing the functioning of a single area of the brain. For a few minutes, they inhibited exactly the area that processes the sense of touch by specifically intervening in its rhythm. As a result, the area that was less networked with other brain regions, its so-called functional connectivity, decreased, and thus also the exchange of information with other brain networks.

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The discovery has led to a new polymer that allows humans to integrate electronics into the brain after challenges with substances such as gold, steel and silicon resulted in scarring of organic tissue.

A major breakthrough in materials research may allow the human brain to link with artificial intelligence, it was announced at an American Chemical Society Fall 2020 event on Monday.

Scarring due to previously used materials can block electrical signals transmitted from computers to the brain, but University of Delaware researchers developed new types of polymers aimed at overcoming the risks.

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A Sound Treatment

Ultrasound is an oddball in the neuromodulation world. Similar to its better-known siblings, such as transcranial direct current stimulation (tDSC) or transcranial magnetic stimulation (TMS), ultrasound changes how neurons fire, which in turn changes their computational output—what we observe as learning, memory, and other behaviors. This idea, dubbed neuromodulation, has taken the neurological world by storm for its near “magical” efficacy for treating people with depression who don’t respond to antidepressants, or people with Parkinson’s disease whose movement patterns are severely disrupted.

Compared to first-generation neuromodulation, where the brain-tweaking gadget is surgically implanted into the brain, ultrasound offers a way to “hack” neural firings from the outside. In a way, the technology uses sound waves to mechanically “shake” the neurons in a circuit back into sequence, so they function in sync as needed and control subsequent outputs like learning, thinking, memory, and decision-making.

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Both genetic and non-genetic factors underlie the intratumoural heterogeneity that fuels cancer evolution. This Review discusses the application of single-cell multi-omics technologies to the study of cancer evolution, which capture and integrate the different layers of heritable information and reveal their complex interplay.

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Every dog owner has their own reasons for getting a pet, whether it is companionship, protection, or simply to have a furry friend to walk with. Each different breed comes with perks and challenges, and owners must be prepared to accommodate each type of dog’s unique health requirements to maximize their lifespan, because the reality is that some dogs are genetically predisposed to live much longer than others.

In order to determine the shortest and longest living dog breeds in the world, 24/7 Tempo reviewed the study, “Methods and mortality results of a health survey of purebred dogs in the UK,” published in the Journal of Small Animal Practice. Breeds for which there was little data or low response rates on surveys sent to owners were not considered. Breeds that are not officially recognized by the American Kennel Club were also not considered. Breed popularity data, as well as height and weight data, comes from the AKC. The height refers to the height of the dog’s shoulder.

Numerous studies have determined that there is a significant link between the size of a dog and the length of its lifespan — larger dogs have noticeably shorter lifespans than smaller dogs, as they age at a faster rate. Yet size and lifespan do not correlate exactly, as certain types of dogs are especially prone to maladies like cancer or heart problems.

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In the fight against Covid-19, cytokine storms are one of the most deadly factors that doctors are battling. This symptom in severe cases of the novel coronavirus can lead to excessive inflammation, swelling, pain, and loss of organ function. It can even cause the immune system to ramp up so much that it starts killing the body’s own cells — instead of just fighting the infection. In serious cases, this can lead to death, as we’ve seen in many cases of severe Covid-19.

In the last few months, researchers have been looking at whether cannabis, or it’s many chemical compounds, might help to fight this deadly effect by bringing down inflammation. Recently, we’ve seen positive results from studies suggesting that CBD, a compound in cannabis, may help fight these cytokine storms.

Now early results from an ongoing Israeli study are adding to the chorus of researchers suggesting that cannabis’ ingredients could be a game changing treatment in the fight against Covid-19. But this study says that terpenes, compounds that provide the aroma and flavor in cannabis and many other plants, may lead to even better results than CBD alone, and might outperform conventional treatments like corticosteroids. Reports from the study show that a combination of CBD with terpenes was 2 times more effective at inhibiting cytokine activity than dexamethasone, a corticosteroid which a recent study found to be an effective treatment for Covid-19 cytokine storms.

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A temperature of 130 degrees Fahrenheit (54.4 degrees Celsius) recorded in California’s Death Valley on Sunday by the US National Weather Service could be the hottest ever measured with modern instruments, officials say.

The reading was registered at 3:41 pm at the Furnace Creek Visitor Center in the Death Valley national park by an automated observation system—an electronic thermometer encased inside a box in the shade.

In 1913, a weather station half an hour’s walk away recorded what officially remains the world record of 134 degrees Fahrenheit (56.7 degrees Celsius). But its validity has been disputed because a superheated sandstorm at the time may have skewed the reading.

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Quantum computing requires meticulously prepared hardware and big budgets, but cloud-based solutions could make the technology available to broader business audiences Several tech giants are racing to achieve “quantum supremacy”, but reliability and consistency in quantum output is no simple trick Covid-19 has prompted some researchers to look at how quantum computing could mitigate future pandemics with scientific precision and speed Quantum computing (QC) has been theorized for decades and has evolved rapidly over the last few years. An escalation in spend and development has seen powerhouses IBM, Microsoft, and Google race for ‘quantum supremacy’ — whereby quantum reliably and consistently outperforms existing computers. But do quantum computers remain a sort of elitist vision of the future or are we on course for more financially and infrastructurally viable applications across industries?

Getting to grips with qubits How much do you know? Ordinary computers (even supercomputers) deploy bits, and these bits comprise of traditional binary code. Computer processes – like code – are made up of countless combinations of 0’s and 1’s. Quantum computers, however, are broken down into qubits. Qubits are capable of ‘superpositions’: effectively adopting both 1 and 0 simultaneously, or any space on the spectrum between these two formerly binary points. The key to a powerful, robust, and reliable quantum computer is more qubits. Every qubit added exponentially increases the processing capacity of the machine.

Qubits and the impact of the superposition give quantum computers the ability to process large datasets within seconds, doing what it would take humans decades to do. They can decode and deconstruct, hypothesize and validate, tackling problems of absurd complexity and dizzying magnitude — and can do so across many different industries.

Wherein lies the issue then? Quantum computing for everybody! We’re still a way off – the general consensus being, it’s 5 years, at least, before this next big wave of computing is seen widely across industries and use cases, unless your business is bustling with the budgets of tech giants like Google, IBM, and the like. But expense isn’t the only challenge.

Frail and demanding — the quantum hardware Quantum computers are interminably intricate machines. It doesn’t take much at all to knock a qubit out of the delicate state of superposition. They’re powerful, but not reliable. The slightest interference or frailty leads to high error rates in quantum processing, slowing the opportunity for more widespread use, and rendering ‘quantum supremacy’ a touch on the dubious side.

Continue reading “The quantum state of play — cloud-based QCaaS and Covid-19” | >

Background:Pantoea is a genus within the Enterobacterales whose members encompass free-living and host-associated lifestyles. Despite our growing understanding of the role of mobile genetic elements in the biology, ecology, and evolution of this bacterial group, few Pantoea bacteriophages have been identified and characterized.

https://www.liebertpub.com/doi/10.1089/phage.2019.

Background: Pantoea is a genus within the Enterobacterales whose members encompass free-living and host-associated lifestyles. Despite our growing understanding of the role of mobile genetic elements in the biology, ecology, and evolution of this bacterial group, few Pantoea bacteriophages have been identified and characterized.

Materials and Methods: A bacteriophage that could infect Pantoea agglomerans was isolated from barnyard soil. We used electron microscopy and complete genome sequencing to identify the viral family, and evaluated its host range across 10 different Pantoea species groups using both bacterial lawn and phage lawn assays. The latter assays were carried out using a scalable microplate assay to increase throughput and enable spectrophotometric quantitation. We also performed a phylogenetic analysis to determine the closest relatives of our phage.

Continue reading “Isolation and Characterization of vB_PagP-SK1, a T7-Like Phage Infecting Pantoea agglomerans” | >