Lifeboat Foundation

How close are we to creating a synthetic human genome?

Creating humans is also an ethical minefield. Unsettled questions about who might own a synthetic human genome abound. Boeke warns that ownership could come down to who ends up funding the project development. Rob Carlson, a co-author of the GP-Write proposal, is even more skeptical of the idea of a patented artificial human genome, pointing out via email that “as soon as there is any possibility of a synthetic genome being used to germinate a live human, then ownership is obviously out of the question anyway…because you are now talking about owning a person.”

Continue reading “Synthetic genomics – Inside the effort to create entire genomes from scratch” »

BEIJING: The head of a leading hospital in China’s central city of Wuhan, the epicentre of a coronavirus outbreak, died of the disease on Tuesday (Feb 18), state television said, becoming the second prominent Chinese doctor to have succumbed to the pathogen.

Liu Zhiming, the director of Wuhan Wuchang Hospital, died at 10.30am, it said.

Newborn screening covers more than 30 conditions. Yet, with genome sequencing, we could screen newborns for several thousand genetic conditions.

In the surveys’ open-ended responses about risks of genome sequencing, parents and clinicians both expressed concerns about psychological distress related to difficult or uncertain results. Clinicians were more likely to raise concerns about returning results for adult-onset conditions, unnecessary parental stress over health problems that might never actually occur, and the possibility of future discrimination against the child on the basis of their genomic information.

Continue reading “Is It Too Soon to Consider Genome Sequencing for Newborns?” »

BEIJING—Clinical trials being conducted in Wuhan to test Gilead Sciences Inc.’s antiviral drug, a promising remedy for the new coronavirus, are going more slowly than hoped for as the drugmaker struggles to recruit qualified patients, underscoring the challenges in quickly developing drugs during outbreaks.

The trials, aimed at testing more than 700 patients infected with the Wuhan coronavirus, have succeeded in recruiting fewer than 200 people after 10 days.

A total of 168 patients with severe symptoms, and 17 patients with mild and moderate symptoms, were recruited at 11 medical institutes across Wuhan, Zhang Xinmin, an official from China’s Ministry of Science and Technology, said at a Saturday press conference.

Continue reading “Gilead’s Coronavirus Drug Trial Slowed by Lack of Eligible Recruits” »

At some point in their life almost everyone will develop a cavity in their teeth and about 70% of the global population will experience varying degrees of gingivitis. Regular brushing is the best way to prevent dental disease, but sometimes that is not enough as microscopic plaque can be left behind after brushing your teeth.

According to the Health 2000 Population Survey over half of Finns aged 30+ suffer from gum disease; and research indicates that undetected oral and chronic infections can contribute to the occurrence of many diseases such as cardiovascular disease, diabetes, and lung cancer as well as increasing the risk of premature delivery.

Aalto University and Helsinki University Hospital researchers have founded Koite Health which is launching a method for home use in the coming weeks that can kill streptococcus mutans bacteria as well as the bacteria that can cause gingivitis, which has been shown to reduce the markers indicating early gingivitis and plaque formation.

James W. Clement is a longevity researcher who was the 12th person on the planet to have his DNA sequenced. In 2010 James launched his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School. Since then Clement has read 20,000 medical research papers on longevity and has acquired one of the largest DNA databases of supercentenarians, the youngest of whom is 106 years old. Most recently James W. Clement is the author of the Switch: Ignite your metabolism with intermittent fasting, protein cycling, and keto. Finally, I know James personally and have gone to visit his previous research lab in Apple Valley, California, so I can honestly say that he is among the most humble humans and the hardest-working longevity researchers that I have ever seen. I have learned a lot from Clement and I hope you do too.

During this 2 hour interview with James W. Clement, we cover a variety of interesting topics such as: Clement’s journey from being a lawyer to becoming a full-time longevity researcher; the name and story behind Better Humans; why James is a transhumanist; why we have to first make it to 100 before we start taking “magic pills”; the switch between mTOR and autophagy; the importance of intermittent fasting, its time and duration; the connection between gut bacteria and dopamine; why the biggest problem of our diet is the overconsumption of both dairy and meat; protein cycling and why we can’t sustain autophagy indefinitely; the dangers of coconut oil; why all centenarian blue zones in the world eat high-carb diets and why we should try keto.

My favorite quote that I will take away from this interview with James W. Clement is:

Magnetic resonance imaging is no longer confined to radiology departments. The U.S. Food and Drug Administration announced Wednesday that it has provided clearance to the “world’s first” bedside MRI system, according to an announcement.

Hyperfine said it will begin shipping its portable, low-field modalities this summer. It’s 510(k) clearance falls on the same day that Yale researchers reported the device can accurately and safely image patient’s brains for stroke. Those preliminary results are set to be presented next week at the American Stroke Association’s International conference in Los Angeles, the group announced.

“We’ve flipped the concept from having to get patients to the MRI to bringing the MRI to the patients,” said Kevin Sheth, MD, senior author and a chief physician at Yale School of Medicine. “This early work suggests our approach is safe and viable in a complex clinical care environment.”

In the blink of an eye, the US cases jump from 15 to 29.

Fourteen Americans evacuated from the Diamond Princess cruise ship on US-chartered flights have tested positive for novel coronavirus, the US departments of State and Health and Human Services said.

The passengers were among more than 300 Americans who had been quarantined on the ship since February 4 at the Japanese port city of Yokohama.

Continue reading “300 Americans evacuated from the Diamond Princess cruise ship are back in the US, including 14 who have coronavirus” »

They beat us at chess and trivia, supplant jobs by the thousands, and are about to be let loose on highways and roads as chauffeurs and couriers.

Now, fresh signs of robot supremacy are emerging on Wall Street in the form of machine stock analysts that make more profitable investment choices than humans. At least, that’s the upshot of one of the first studies of the subject, whose preliminary results were released in January.

Buy recommendations peddled by robo-analysts, which supposedly mimic what traditional equity research departments do but faster and at lower costs, outperform those of their flesh-and-blood counterparts over the long run, according to Indiana University professors.