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Category: biotech/medical – Page 1629

Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of—and a treatment for—a previously unknown severe auto inflammatory syndrome affecting an 18-year-old girl since infancy.

The technology, tailored to the patient’s own genetic code at a single cell level, helped the researchers characterize an unknown mutation in a gene called JAK1 that caused the patient’s immune system to be permanently turned on, resulting in rashes over much of her skin, growth abnormalities, kidney failure, allergic hypersensitivities, and an unusual inflammatory condition throughout the digestive tract.

The study, led by Dusan Bogunovic, Ph.D., Associate Professor of Microbiology, and Pediatrics, at the Icahn School of Medicine at Mount Sinai, faculty member of The Mindich Child Health and Development Institute and the Precision Immunology Institute at Mount Sinai, and Director of the Center for Inborn Errors of Immunity, was published in the August 3 issue of the journal Immunity. The discovery points toward new ways to study how genetic diseases manifest and presents a model of personalized diagnosis and treatment for patients with genetic diseases.

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Moderna is charging between $32 to $37 per dose for its coronavirus vaccine for some customers, under cheaper “pandemic pricing,” it said Wednesday.

The Cambridge, Massachusetts-based company is currently in discussion for larger volume agreements that will have a lower price, Moderna CEO Stephane Bancel said on a conference call discussing the company’s second-quarter financial results.

“We are working with governments around the world and others to ensure a vaccine is accessible regardless of ability to pay,” he said. “We’re currently in a pandemic as defined by WHO. At Moderna, like many experts, we believe the virus is not going away and there will be a need to vaccinate people or give them a boost for many years to come.”

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In COVID-19, the sense of smell can diminish, vanish, or oddly skew, for weeks or months. The loss usually starts suddenly and is more than the temporarily dulled chemical senses of a stuffy nose from the common cold. As researchers followed up mounting reports of loss of olfaction, a surprising source of perhaps the longest-lasting cases emerged: stem cells in the olfactory epithelium.

A Common Symptom

Facebook groups may be ahead of the medical literature in providing vivid descriptions of the loss of olfaction as people swap advice and compare how long they’ve been unable to smell. The experiences can be bizarre, but at the same time, shared.

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face_with_colon_three yay closer to foglet bodies: 3.

Is the T-1000 no longer science fiction?

It is a human dream to realize a robot with automatic mechanical functions similar to the robots presented in several science-fiction movies and series such as “Ex Machina”, “Black Mirror”, “The Terminator”, etc.

More specifically, the idea of a liquid-metal-based robot able to transform its structure from solid to liquid, slip through narrow channels, and self-repair from any physical damage has always fascinated the scientific community engaged in cutting-edge technological discoveries. Beside the science-fiction background, micromachines able to gain energy from chemical reactions are attracting lots of attention as they emerged as ideal candidates for microrobots used in the field of microfabrication, detection/sensing, and personalized drug delivery.

Continue reading “Liquid-Metal-Driven Micromachines for the Next Cutting-edge Technology” | >

The Centers for Disease Control and Prevention (CDC) warned parents and doctors Tuesday that it expects another outbreak this year of a rare but life-threatening condition that mostly affects children.

Outbreaks of acute flaccid myelitis (AFM), a serious neurologic condition that can cause paralysis, typically peak every two years between August and November.

The last peak occurred in 2018, when 238 cases were reported to the CDC.

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It’s no secret that healthcare costs have risen faster than inflation for decades. Some experts estimate that healthcare will account for over 20% of the US GDP by 2025. Meanwhile, doctors are working harder than ever before to treat patients as the U.S. physician shortage continues to grow. Many medical professionals have their schedules packed so tightly that much of the human element which motivated their pursuit of medicine in the first place is reduced.

In healthcare, artificial intelligence (AI) can seem intimidating. At the birthday party of a radiologist friend, she gently expressed how she felt her job would be threatened by AI in the coming decade. Yet, for most of the medical profession, AI will be an accelerant and enabler, not a threat. It would be good business for AI companies as well to help, rather than attempt to replace, medical professionals.

In a previous article, I expressed three ways in which I consistently see AI adding value: speed, cost and accuracy. In healthcare, it’s no different. Here are three examples of how AI will change healthcare.

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Consuming a single dose of the psychedelic brew ayahuasca can result in lasting changes in higher-order cognitive brain networks, according to a new study published in the Journal of Psychopharmacology.

Ayahuasca, a concoction used for centuries by indigenous Amazon tribes, contains the powerful psychedelic drug dimethyltryptamine (DMT) and monoamine oxidase inhibitors. The brew is typically prepared using leaves from the Psychotria viridis shrub and the bark of the Banisteriopsis caapi vine.

The new neuroimaging research suggests that ayahuasca may produce long-lasting effects on mood by altering the functional connectivity of the brain’s salience and default mode networks.

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To that end, Barry Prentice, who leads the Canadian company Buoyant Aircraft Systems International, hopes to use airships to transport pre-built structures for schools and housing to remote parts of Canada that lack good roads.

And earlier this year, French airship company Flying Whales (I mean, how can you not adore that name?) received $23 million in funding from the government of Quebec to build cargo-carrying Zeppelins.

Given our current pandemic-dominated reality, it’s hard to imagine a future of seamless global travel of any kind, much less on an airship. But that future will, thankfully, arrive (though when is anyone’s guess). As calls for climate action get louder and the costs associated with airships drop—as the cost of any new technology tends to do with time—we may find ourselves going retro and being ferried across the globe by giant helium-filled balloons.

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