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Scientists created ‘cyborg cells’ that are partially alive, but can be programmed

Scientists have managed to do something truly groundbreaking. According to a new paper published in Advanced Science, researchers have created programmable cyborg cells that could help revolutionize medicine and environmental cleanup efforts. The new research, which was carried out by researchers at the University of California, Davis, shows that it is possible to create semi-living cyborg cells that retain the capabilities of living cells, but are unable to divide and grow.

What’s Next?: The 2023 Healthcare Industry Trend Report

In 2023, the US healthcare industry is again facing several significant challenges, including ongoing high inflation rates, labor shortages, and the persistent impact of the COVID-19 pandemic. Despite continued difficulties, leaders in the space are working to find innovative solutions to improve the current system while looking ahead at the promising future of medicine that appears to have already arrived.

From artificial intelligence-based medicine to breakthroughs in precision neuroscience, we outline key trends expected to shape the healthcare landscape in 2023 and beyond.

The 2023 Trend Report: Impactful Healthcare Innovations to Watch.

Goodbye coffee, hello brain stimulation? People are zapping their brains at home to clear brain fog

𝐏𝐞𝐨𝐩𝐥𝐞 𝐚𝐫𝐞 𝐳𝐚𝐩𝐩𝐢𝐧𝐠 𝐭𝐡𝐞𝐢𝐫 𝐛𝐫𝐚𝐢𝐧𝐬 𝐚𝐭 𝐡𝐨𝐦𝐞 𝐭𝐨 𝐢𝐦𝐩𝐫𝐨𝐯𝐞 𝐟𝐨𝐜𝐮𝐬 𝐚𝐧𝐝 𝐜𝐥𝐞𝐚𝐫 𝐛𝐫𝐚𝐢𝐧 𝐟𝐨𝐠. 𝐁𝐮𝐭 𝐢𝐬 𝐢𝐭 𝐬𝐚𝐟𝐞?

In 2021, Craig Gibbons was diagnosed with Lyme disease. His doctor prescribed him antibiotics, but the medication failed to eliminate one of his most debilitating symptoms: a lasting brain fog that made it difficult for him to focus or recall information.

So he went with a different approach: at-home brain stimulation.

Over the past few years, Gibbons had been experimenting with transcranial direct current stimulation, or tDCS, which delivers weak electrical currents to the brain through electrodes attached to the head.


Anna Wexler, an assistant professor of medical ethics and health policy at the University of Pennsylvania, studies why and how people use brain stimulation at home. She’s found that people are using the devices to treat mental health disorders or to improve mental performance.

“Depression and anxiety are the top two indications for people,” Wexler said. “But other reasons people used it for were for enhancement, so to improve focus, to improve memory, things like that.”

Engineering Cyborg Bacteria Through Intracellular Hydrogelation

Synthetic biology has made major strides towards the holy grail of fully programmable bio-micromachines capable of sensing and responding to defined stimuli regardless of their environmental context. A common type of bio-micromachines is created by genetically modifying living cells.[ 1 ] Living cells possess the unique advantage of being highly adaptable and versatile.[ 2 ] To date, living cells have been successfully repurposed for a wide variety of applications, including living therapeutics,[ 3 ] bioremediation,[ 4 ] and drug and gene delivery.[ 5, 6 ] However, the resulting synthetic living cells are challenging to control due to their continuous adaption and evolving cellular context. Application of these autonomously replicating organisms often requires tailored biocontainment strategies,[ 7-9 ] which can raise logistical hurdles and safety concerns.

In contrast, nonliving synthetic cells, notably artificial cells,[ 10, 11 ] can be created using synthetic materials, such as polymers or phospholipids. Meticulous engineering of materials enables defined partitioning of bioactive agents, and the resulting biomimetic systems possess advantages including predictable functions, tolerance to certain environmental stressors, and ease of engineering.[ 12, 13 ] Nonliving cell-mimetic systems have been employed to deliver anticancer drugs,[ 14 ] promote antitumor immune responses,[ 15 ] communicate with other cells,[ 16, 17 ] mimic immune cells,[ 18, 19 ] and perform photosynthesis.

Quantifying Biological Age: Blood Test #1 in 2023

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Ideal blood pressure may remodel brain clearance pathways linked to brain health, dementia

𝐈𝐝𝐞𝐚𝐥 𝐛𝐥𝐨𝐨𝐝 𝐩𝐫𝐞𝐬𝐬𝐮𝐫𝐞 𝐦𝐚𝐲 𝐫𝐞𝐦𝐨𝐝𝐞𝐥 𝐛𝐫𝐚𝐢𝐧 𝐜𝐥𝐞𝐚𝐫𝐚𝐧𝐜𝐞 𝐩𝐚𝐭𝐡𝐰𝐚𝐲𝐬 𝐥𝐢𝐧𝐤𝐞𝐝 𝐭𝐨 𝐛𝐫𝐚𝐢𝐧 𝐡𝐞𝐚𝐥𝐭𝐡, 𝐝𝐞𝐦𝐞𝐧𝐭𝐢𝐚

𝘾𝙡𝙤𝙨𝙚 𝙧𝙚𝙫𝙞𝙚𝙬 𝙤𝙛 𝙈𝙍𝙄 𝙨𝙘𝙖𝙣𝙨 𝙛𝙤𝙪𝙣𝙙 𝙢𝙤𝙧𝙚 𝙞𝙣𝙩𝙚𝙣𝙨𝙞𝙫𝙚 𝙝𝙞𝙜𝙝 𝙗𝙡𝙤𝙤𝙙 𝙥𝙧𝙚𝙨𝙨𝙪𝙧𝙚 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 (𝙩𝙖𝙧𝙜𝙚𝙩𝙚𝙙 𝙩𝙤 𝙖𝙘𝙝𝙞𝙚𝙫𝙚 𝙖 𝙨𝙮𝙨𝙩𝙤𝙡𝙞𝙘 𝙥𝙧𝙚𝙨𝙨𝙪𝙧𝙚 𝙡𝙚𝙨𝙨 𝙩𝙝𝙖𝙣 120 𝙢𝙢 𝙃𝙜) 𝙬𝙖𝙨 𝙢𝙤𝙧𝙚 𝙚𝙛𝙛𝙚𝙘𝙩𝙞𝙫𝙚 𝙩𝙝𝙖𝙣 𝙖 𝙡𝙚𝙨𝙨-𝙞𝙣𝙩𝙚𝙣𝙨𝙚 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 𝙜𝙤𝙖𝙡 𝙤𝙛 140 𝙢𝙢 𝙃𝙜 𝙨𝙮𝙨𝙩𝙤𝙡𝙞𝙘 𝙞𝙣 𝙖𝙘𝙝𝙞𝙚𝙫𝙞𝙣𝙜 𝙖 𝙥𝙤𝙨𝙞𝙩𝙞𝙫𝙚 𝙨𝙩𝙧𝙪𝙘𝙩𝙪𝙧𝙖𝙡 𝙘𝙝𝙖𝙣𝙜𝙚 𝙞𝙣 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣’𝙨 𝙥𝙚𝙧𝙞𝙫𝙖𝙨𝙘𝙪𝙡𝙖𝙧 𝙨𝙥𝙖𝙘𝙚𝙨: 𝙥𝙖𝙩𝙝𝙬𝙖𝙮𝙨 𝙩𝙝𝙖𝙩 𝙖𝙧𝙚 𝙞𝙢𝙥𝙤𝙧𝙩𝙖𝙣𝙩 𝙩𝙤 𝙘𝙡𝙚𝙖𝙧𝙞𝙣𝙜 𝙩𝙤𝙭𝙞𝙣𝙨 𝙖𝙣𝙙 𝙤𝙩𝙝𝙚𝙧 𝙗𝙮𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙨.

𝙄𝙛 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣 𝙘𝙖𝙣𝙣𝙤𝙩 𝙥𝙧𝙤𝙥𝙚𝙧𝙡𝙮 𝙘𝙡𝙚𝙖𝙧 𝙢𝙚𝙩𝙖𝙗𝙤𝙡𝙞𝙘 𝙗𝙮𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙨, 𝙩𝙝𝙚𝙮 𝙖𝙘𝙘𝙪𝙢𝙪𝙡𝙖𝙩𝙚 𝙖𝙣𝙙 𝙢𝙖𝙮 𝙘𝙤𝙣𝙩𝙧𝙞𝙗𝙪𝙩𝙚 𝙩𝙤 𝙩𝙝𝙚 𝙙𝙚𝙫𝙚𝙡𝙤𝙥𝙢𝙚𝙣𝙩 𝙤𝙛 𝙙𝙚𝙢𝙚𝙣𝙩𝙞𝙖, 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙨𝙖𝙞𝙙.


Embargoed until 4 a.m. CT/5 a.m. ET, Thursday, Feb. 2, 2023

(NewMediaWire) — February 2, 2023 — DALLAS Among people who received more intensive treatment for high blood pressure, evaluations of MRI scans indicated a positive change in brain structures involved in its ability to clear toxins and other byproducts, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2023. The meeting, held in person in Dallas and virtually, Feb. 8–10, 2023, is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health.

The study is the first to examine whether intensive blood pressure treatment may slow, or reverse structural changes related to the volume of the brain’s perivascular spaces, areas of the brain around the blood vessels that are involved in the clearance of toxins and other byproducts. These areas tend to enlarge as people get older or have more cardiovascular risk factors.

Clinical trials show encouraging safety profile for brain-computer interface turning thoughts into action

PROVIDENCE, R.I. [Brown University] — More than two decades ago, a team of Brown University researchers set out with an ambitious goal to provide people with paralysis a revolutionary neurotechnology capable of turning thoughts about movement into actual action, using a tiny device that would one day be implanted in the surface of the brain. Their work led to an ongoing, multi-institution effort to create the BrainGate brain-computer interface, designed to allow clinical trial participants with paralysis to control assistive devices like computers or robotic limbs just by thinking about the action they want to initiate.

Open Access Paper:

https://n.neurology.org/content/early/2023/01/13/WNL.


In an important step toward a medical technology that could help restore independence of people with paralysis, researchers find the investigational BrainGate neural interface system has low rates of associated adverse events.

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