Researchers are now calling for a set of guidelines, similar to those used in animal research, to guide the humane use of brain organoids and other experiments that could achieve consciousness. In June, the US National Academies of Sciences, Engineering, and Medicine began a study with the aim of outlining the potential legal and ethical issues associated with brain organoids and human-animal chimaeras.
A handful of experiments are raising questions about whether clumps of cells and disembodied brains could be sentient, and how scientists would know if they were.
An international team of researchers has developed a multifunctional skin-mounted microfluidic device that is able to measure stress in people in multiple ways. In their paper published in Proceedings of the National Academy of Sciences, the group describes their device and how it could be useful.
Prior research has shown that long-term stress can damage a person’s health. It can lead to diabetes, depression, obesity and a host of other problems. Some have suggested that one of the ways to combat stress is to create a means for alerting a person to their heightened stress so that they might take action to reduce it. To that end, prior teams have developed skin-adhesive devices that that collect sweat samples. The tiny samples contain small amounts of cortisol, a hormone that can be used as a marker of stress levels. In this new effort, the researchers have improved on these devices by developing one that measures more than just cortisol levels and is much more comfortable.
The researchers began with the notion that in order to convince people to wear a device full time, it had to be both useful and comfortable. The solved the latter issue by making their device out of soft materials that adhere gently to the skin. They also used a skeletal design for their microfluidic sweat-collection apparatus—a flexible mesh. They also added more functionality. In addition to cortisol, their device is able to measure glucose and vitamin C levels. They also added electrodes underneath that are able to measure sweat rate and electrical conductivity of the skin, both of which change in response to stress. They also added a wireless transmitter that sends all of the data to a nearby smartphone running the device’s associated app.
Crews working on the largest U.S. experiment designed to directly detect dark matter completed a major milestone last month, and are now turning their sights toward startup after experiencing some delays due to global pandemic precautions.
U.S. Department of Energy officials on Sept. 21 formally signed off on project completion for LUX-ZEPLIN, or LZ: an ultrasensitive experiment that will use 10 metric tons of liquid xenon to hunt for signals of interactions with theorized dark matter particles called WIMPs, or weakly interacting massive particles. DOE’s project completion milestone is called Critical Decision 4, or CD-4.
Dark matter makes up an estimated 85 percent of all matter in the universe. We know it’s there because of its observed gravitational effects on normal matter, but we don’t yet know what it is. LZ is designed to detect the two flashes of light that occur if a WIMP interacts with the nucleus of a xenon atom.
Online health care and medtech AI have risen in prominence in the country as the government seeks more equal access to medicines and treatment for its citizens, spread across a vast land mass. The urgency has been heightened by the impact from Covid-19 – with Indonesia recently overtaking the Philippines as the hardest-hit country in Southeast Asia.
Indonesia’s fast-growing manufacturing sector also presents opportunities for medtech innovation as well as research and development.
Overactivity in the subgenual anterior cingulate cortex underlies several key symptoms of depression, anxiety, and heart disease.
Summary: Over-activity in the subgenual anterior cingulate cortex underlies several key symptoms of depression, anxiety, and heart disease.
Source: University of Cambridge
Over-activity in a single brain region called the subgenual anterior cingulate cortex (sgACC) underlies several key symptoms of mood and anxiety disorders, but an antidepressant only successfully treats some of the symptoms.
KENNEDY SPACE CENTER (FL), October 19, 2020 – The Center for the Advancement of Science in Space (CASIS) and the National Science Foundation (NSF) announced three flight projects that were selected as part of a joint solicitation focused on leveraging the International Space Station (ISS) U.S. National Laboratory to further knowledge in the fields of tissue engineering and mechanobiology. Through this collaboration, CASIS, manager of the ISS National Lab, will facilitate hardware implementation, in-orbit access, and astronaut crew time on the orbiting laboratory. NSF invested $1.2 million in the selected projects, which are seeking to advance fundamental science and engineering knowledge for the benefit of life on Earth.
This is the third collaborative research opportunity between CASIS and NSF focused on tissue engineering. Fundamental science is a major line of business for the ISS National Lab, and by conducting research in the persistent microgravity environment offered by the orbiting laboratory, NSF and the ISS National Lab will drive new advances that will bring value to our nation and spur future inquiries in low Earth orbit.
Microgravity affects organisms—from viruses and bacteria to humans, inducing changes such as altered gene expression and DNA regulation, changes in cellular function and physiology, and 3D aggregation of cells. Spaceflight is advancing research in the fields of pharmaceutical research, disease modeling, regenerative medicine, and many other areas within the life sciences. The selected projects will utilize the ISS National Lab and its unique environment to advance fundamental and transformative research that integrates engineering and life sciences.
“This is kind of a nice bookend to 16 years of research,” says Deisseroth, a neuroscientist and bioengineer at Stanford University. “It took years and years for us to sort out how to make it work.”
“The result is described this month in the journal Nature Biotechnology.”
“Optogenetics involves genetically engineering animal brains to express light-sensitive proteins—called opsins—in the membranes of neurons.”
Optogenetics can now control neural circuits at unprecedented depths within living brain tissue without surgery.
