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Papers referenced in the video:

Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk:
https://www.jacc.org/doi/10.1016/j.jacc.2020.10.

The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling:
https://www.sciencedirect.com/science/article/pii/S0753332220309781

Joint distribution of lipoprotein cholesterol classes. The Framingham study:
https://pubmed.ncbi.nlm.nih.gov/6573877/

Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS):
https://pubmed.ncbi.nlm.nih.gov/20223457/

Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease:

Criticism of a recent video denouncing resveratrol.


Following Doctor Brad Stanfield’s latest ‘why I stopped video’, this last one about resveratrol and pterostilbene, many of you asked for my opinion, well here it is.

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Humans are distinguished from other species by several aspects of cognition. While much comparative evolutionary neuroscience has focused on the neocortex, increasing recognition of the cerebellum’s role in cognition and motor processing has inspired considerable new research. Comparative molecular studies, however, generally continue to focus on the neocortex. We sought to characterize potential genetic regulatory traits distinguishing the human cerebellum by undertaking genome-wide epigenetic profiling of the lateral cerebellum, and compared this to the prefrontal cortex of humans, chimpanzees, and rhesus macaque monkeys. We found that humans showed greater differential CpG methylation–an epigenetic modification of DNA that can reflect past or present gene expression–in the cerebellum than the prefrontal cortex, highlighting the importance of this structure in human brain evolution. Humans also specifically show methylation differences at genes involved in neurodevelopment, neuroinflammation, synaptic plasticity, and lipid metabolism. These differences are relevant for understanding processes specific to humans, such as extensive plasticity, as well as pronounced and prevalent neurodegenerative conditions associated with aging.

Citation: Guevara EE, Hopkins WD, Hof PR, Ely JJ, Bradley BJ, Sherwood CC (2021) Comparative analysis reveals distinctive epigenetic features of the human cerebellum. PLoS Genet 17: e1009506. https://doi.org/10.1371/journal.pgen.

Editor: Takashi Gojobori, National Institute of Genetics, JAPAN.

The CEO of Pfizer says that people who got the company’s version of the COVID-19 vaccine will likely need a booster shot within a year.

Albert Bourla made the announcement in an interview with CNBC correspondent Bertha Coombs that was filmed two weeks ago and released publicly on Thursday.

“Likely scenarios is there will likely be a need for a third dose somewhere between six and 12 months and then from there, there will be an annual vaccination,” says Bourla.