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Category: biotech/medical – Page 1550

A team led by University of Minnesota Twin Cities researchers has discovered a groundbreaking one-step process for creating materials with unique properties, called metamaterials. Their results show the realistic possibility of designing similar self-assembled structures with the potential of creating “built-to-order” nanostructures for wide application in electronics and optical devices.

The research was published and featured on the cover of Nano Letters, a peer-reviewed scientific journal published by the American Chemical Society.

In general, metamaterials are made in the lab so as to provide specific physical, chemical, electrical, and optical properties otherwise impossible to find in naturally occurring materials. These materials can have which make them ideal for a variety of applications from optical filters and medical devices to aircraft soundproofing and infrastructure monitoring. Usually these nano-scale materials are painstakingly produced in a specialized clean room environment over days and weeks in a multi-step fabrication process.

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Moonshot Thinking For Aging, Mental Health, And Drug Re-Purposing — Dr. Tim R. Peterson.

Washington University in St. Louis.

Dr. Tim R. Peterson PhD. is Assistant Professor, in the Department of Medicine, at Washington University in St. Louis.

Continue reading “Dr. Tim R. Peterson — Moonshot Thinking For Aging, Mental Health, And Drug Re-Purposing” | >

Very interesting.

Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study conducted by researchers at the Spanish National Cancer Research Centre (CNIO) in collaboration with the COVID-IFEMA Field Hospital, published in the journal Aging. The study, led by Maria A. Blasco and whose first authors are Raúl Sánchez and Ana Guío-Carrión, postulates that telomere shortening as a consequence of the viral infection impedes tissue regeneration and that this is why a significant number of patients suffer prolonged sequelae.

Blasco was already developing a therapy to regenerate lung tissue in pulmonary fibrosis patients; she now believes that this treatment — which should still take at least a year and a half to become available — could also help those who have lung lesions remaining after overcoming COVID-19.

Telomeres and tissue regeneration

The Telomeres and Telomerase Group, led by Blasco at the CNIO, has been researching the role of telomeres in tissue regeneration for decades. Telomeres are structures that protect the chromosomes within each cell of the organism. It is known that telomere length is an indicator of ageing: each time a cell divides, its telomeres shorten until they can no longer perform their protective function and the cell, which now becomes damaged, stops dividing. Throughout life, cells are constantly dividing to regenerate tissues, and when they stop doing so because the telomeres are too short, the body ages.

Continue reading “Study links severe COVID-19 disease to short telomeres” | >

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature biosensors and drug-delivery containers. Pioneered at the California Institute of Technology in 2006, DNA origami has attracted hundreds of new researchers over the past decade, eager to build receptacles and sensors that could detect and treat disease in the human body, assess the environmental impact of pollutants, and assist in a host of other biological applications.

Although the principles of DNA are straightforward, the technique’s tools and methods for designing new structures are not always easy to grasp and have not been well documented. In addition, scientists new to the method have had no single reference they could turn to for the most efficient way of building DNA structures and how to avoid pitfalls that could waste months or even years of research.

That’s why Jacob Majikes and Alex Liddle, researchers at the National Institute of Standards and Technology (NIST) who have studied DNA origami for years, have compiled the first detailed tutorial on the technique. Their comprehensive report provides a step-by-step guide to designing DNA origami nanostructures, using state-of-the-art tools. Majikes and Liddle described their work in the Jan .8 issue of the Journal of Research of the National Institute of Standards and Technology.

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Gene therapies are opening up possibilities that were once reserved for science fiction.

At Harvard University, Professor of Genetics David Sinclair says he believes it’s possible to unlock the fountain of youth, and gene therapy is the key.

Sinclair spent two years trying to correct the vision of a mouse using gene therapy, and finally succeeded in doing it.

Although these discoveries are encouraging, Sinclair cautions that people set their expectations realistically.

Continue reading “Gene Therapies and the Promise of the Fountain of Youth” | >

Octopus and squid make strange evolutionary shortcuts in adaptation. Evolution is an intricate process of change.

By Jonny Lupsha, News Writer

According to Science Alert, species of squid and octopus may yet have some surprises in store for us. “In a surprising twist, scientists discovered that octopuses, along with some squid and cuttlefish species, routinely edit their RNA (ribonucleic acid) sequences to adapt to their environment,” the article said.

“When an organism changes in some fundamental way, it typically starts with a genetic mutation—a change to the DNA. Those genetic changes are then translated into action by DNA’s molecular sidekick, RNA.”

Continue reading “Octopuses, Some Squid Edit RNA Sequences to Adapt to Environment” | >

Methylation and demethylation of DNA, RNA and proteins has emerged as a major regulatory mechanism. Studying the function of these modifications would benefit from tools for their site‐specific inhibition and timed removal. S ‐Adenosyl‐L‐methionine (AdoMet) analogs in combination with methyltransferases (MTases) have proven useful to map or block and release MTase target sites, however their enzymatic generation has been limited to aliphatic groups at the sulfur atom. We engineered a SAM synthetase from Cryptosporidium hominis (PC‐ChMAT) for efficient generation of AdoMet analogs with photocaging groups that are not accepted by any WT MAT reported to date. The crystal structure of PC‐ChMAT at 1.87 Å revealed how the photocaged AdoMet analog is accommodated and guided engineering of a thermostable MAT from Methanocaldococcus jannaschii. PC‐MATs were compatible with DNA‐ and RNA‐MTases, enabling sequence‐specific modification (“writing”) of plasmid DNA and light‐triggered removal (“erasing”).

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Biotin is also known as vitamin H, named for the German words “Haar” and “Haut,” which mean hair and skin. This was due to the fact that even slight deficiencies cause hair thinning, skin rash or brittle fingernails. New research, just published in PNAS, now shows that some forms of severe neurodegeneration, like the frontotemporal dementia seen in Alzheimer’s and Parkinson’s, can directly result from lack of sufficient biotin.

The authors discovered this by looking at fruit flies with dementia. Now, before anyone chuckles, actually make a nice model of Alzheimer’s or other diseases when they are given the right . Human versions of defective MAPT (tau) genes cause these flies to develop tauopathies that resemble those that occur in our own brains. To delve deeper into the neurotoxicity of tau, they looked at over 7000 fly genes in a forward genetic screen before zeroing in on one significantly modified toxicity of the tauR406W mutant. This gene, Btnd, encodes the biotinidase enzyme that extracts biotin from food sources or recycles it from used enzymes.

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TOKYO (Reuters) — Men wearing traditional loin clothes and women dressed in white robes clapped and chanted before going into an ice water bath during a Shinto ritual at a Tokyo shrine on Sunday to purify the soul and pray for the end of the COVID-19 pandemic.

Only a dozen people took part in the annual event at Teppou-zu Inari Shrine, scaled down this year due to the health crisis, compared to over a hundred in early 2020. Spectators were not allowed at the event.

After doing warming-up exercises and chanting under a clear sky with outside temperatures at 5.1 degree Celsius (41.18 Fahrenheit), the nine male and three female participants went into a bath filled with cold water and large ice blocks. “I prayed that the coronavirus comes to an end as soon as possible,” said 65-year-old participant Shinji Ooi, who heads the Shrine’s ‘Yayoikai’ parishioner group, after the ritual.

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