Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 155

While current treatments for ailments related to aging and diseases like type 2 diabetes, Alzheimer’s, and Parkinson’s focus on managing symptoms, Texas A&M researchers have taken a new approach to fight the battle at the source: recharging mitochondrial power through nanotechnology.

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When we need to recharge, we might take a vacation or relax at the spa. But what if we could recharge at the cellular level, fighting against aging and disease with the microscopic building blocks that make up the human body?

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When we need to recharge, we might take a vacation or relax at the spa. But what if we could recharge at the cellular level, fighting against aging and disease with the microscopic building blocks that make up the human body?

The ability to recharge cells diminishes as humans age or face diseases. Mitochondria, often called the powerhouse of the cell, are central to energy production. When mitochondrial function declines, it leads to fatigue, tissue degeneration, and accelerated aging. Activities that once required minimal recovery now take far longer, highlighting the role that these organelles play in maintaining vitality and overall health.

While current treatments for ailments related to aging and diseases like type 2 diabetes, Alzheimer’s, and Parkinson’s focus on managing symptoms, Texas A&M researchers have taken a new approach to fight the battle at the source: recharging mitochondrial power through nanotechnology.

Read more | >

Ribonucleic acid (RNA) is a vital biological molecule that plays a significant role in the genetics of organisms and is essential to the origin and evolution of life. Structurally similar to DNA, RNA carries out various biological functions, largely determined by its spatial conformation, i.e. the way the molecule folds in on itself.

Now, a paper published in the journal Proceedings of the National Academy of Sciences (PNAS) describes for the first time how the process of RNA folding at low temperatures may open up a novel perspective on primordial biochemistry and the evolution of life on the planet.

The study is led by Professor Fèlix Ritort, from the Faculty of Physics and the Institute of Nanoscience and Nanotechnology (IN2UB) of the University of Barcelona, and is also signed by UB experts Paolo Rissone, Aurélien Severino, and Isabel Pastor.

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Last month, a team from North Carolina State University and Johns Hopkins University found a workaround. They embedded DNA molecules, encoding multiple images, into a branched gel-like structure resembling a brain cell.

Dubbed “dendricolloids,” the structures stored DNA files far better than those freeze-dried alone. DNA within dendricolloids can be repeatedly dried and rehydrated over roughly 170 times without damaging stored data. According to one estimate, each DNA strand could last over two million years at normal freezer temperatures.

Unlike previous DNA computers, the data can be erased and replaced like memory on classical computers to solve multiple problems—including a simple chess game and sudoku.

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The FDA approved amivantamab-vmjw in combination with standard chemotherapy for the treatment of certain adults with non-small cell lung cancer, according to the agent’s manufacturer.

The indication applies to adults with locally advanced or metastatic NSCLC with EGFR exon 19 deletions or L858R substitution mutations whose disease progressed on or following treatment with an EGFR tyrosine kinase inhibitor.

Amivantamab-vmjw (Rybrevant, Janssen) is an EGFR and mesenchymal epithelial transition (MET) factor bispecific antibody that targets activating and resistant EGFR and MET mutations and amplifications.

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