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In this video, Drs Irina and Mike Conboy talk about their theory of why we age and introduce Neutral Blood Exchange, which came from their original parabiosis experiments documented in a 2005 paper.

Our guests today are Drs. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley. their discovery of the rejuvenating effects of young blood through parabiosis in a seminal paper published in Nature in 2005 paved the way for a thriving field of rejuvenation biology. The Conboy lab currently focuses on broad rejuvenation of tissue maintenance and repair, stem cell niche engineering, elucidating the mechanisms underlying muscle stem cell aging, directed organogenesis, and making CRISPR a therapeutic reality.

Papers mentioned in this video.
Plasma dilution improves cognition and attenuates neuroinflammation in old mice.
https://pubmed.ncbi.nlm.nih.gov/33191466/
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.
https://pubmed.ncbi.nlm.nih.gov/32474458/
Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
https://pubmed.ncbi.nlm.nih.gov/15716955/

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Great exclusive interview by longevity expert, PhD. Professor, Systems Biology. Director, Chronic Metabolic and Rare Diseases Systems Biology Initiative (ChroMe RaDSBIn) facebook.com/LifetimeTrustnet/posts/1021975448543419


Dr. Ancha Baranova interview on longevity and Covid technologies.

She discovered many biomarkers for chronic liver diseases, cancer and other illnesses, a biosynthesis of the melanin in human adipose, two novel properties of cell-free DNA, and a variety of novel functions for known biomolecules.

The findings, published in Nature Communications, could have important implications for human health: minis have been found at every type of synapse studied so far, and defects in miniature neurotransmission have been linked to range of neurodevelopmental disorders in children. Figuring out how a reduction in miniature neurotransmission changes the structure of synapses, and how that in turn affects behavior, could help to better understand neurodegenerative disorders and other brain conditions.


Summary: Study reveals how miniature release events help to keep neurons intact and preserve motor neuron function in aging insects.

Source: EPFL

Neurons communicate through rapid electrical signals that regulate the release of neurotransmitters, the brain’s chemical messengers. Once transmitted across a neuron, electrical signals cause the juncture with another neuron, known as a synapse, to release droplets filled with neurotransmitters that pass the information on to the next neuron. This type of neuron-to-neuron communication is known as evoked neurotransmission.

However, some neurotransmitter-packed droplets are released at the synapse even in the absence of electrical impulses. These miniature release events — or minis — have long been regarded as ‘background noise’, says Brian McCabe, Director of the Laboratory of Neural Genetics and Disease and a Professor in the EPFL Brain Mind Institute.

Representatives of numerous pathogenic fungal species are finding new habitat on microplastic particles in the soil and could thus be one of the possible causes of an increase in fungal infections. Researchers from Bayreuth, Hannover and Munich demonstrated this in a new study. Using high-throughput methods, the scientists analyzed fungal communities from soil samples taken from sites near human settlements in western Kenya. The findings of this research have been published in the journal Scientific Reports.

This study is the first to focus on fungal communities on in the . Many of the species detected belong to groups of fungi that are pathogenic to plants, animals and humans. Pathogenic microfungi are able to colonize the otherwise inhospitable surfaces of particles due to their characteristic adhesive lifestyle. Furthermore, they are able to withstand strong solar radiation and heat to which they are exposed on soil surfaces.

“We were able to observe all stages of fungal biofilm formation on the microplastic particles recovered from the . In doing so, we were able to demonstrate that fungi not only grow, but also reproduce in the so-called plastisphere. The data we obtained from microscopic examinations and DNA analyses supports the assumption that fungi systematically colonize microplastics in the soil. Moreover, they provide evidence that microplastics in soil accumulate certain pathogenic fungal species: some species dangerous to humans, including black fungi and cryptococcal yeast fungi, are present on the surfaces of microplastic particles in higher concentrations than in the surrounding soil. Our study therefore justifies the presumption that microplastics in soil are a potential source of fungal infections,” says Gerasimos Gkoutselis M.Sc., lead author of the study and doctoral student at the University of Bayreuth’s Department of Mycology.