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Category: biotech/medical – Page 1,480

Wonder Drug Could Provide Protection Against Depression

With 17.3 million adult Americans affected, depression is one of the most prevalent mental disorders in the country. A gloomy or depressed mood that lasts for two weeks or more is considered major depression.

Depression is distinct from common mood swings and brief emotional reactions to problems in daily life. Depression may develop into a serious medical condition, particularly if it is recurring and of moderate to severe intensity. The afflicted individual may experience severe suffering and perform badly at work, in school, and with family. In the worst cases, depression might result in suicide.

Since its introduction in the late 1980s to prevent heart attack and stroke, statins have been hailed as a wonder drug and prescribed to tens of millions of individuals. However, some research has suggested that the medications may still have other benefits, particularly those for mental health. A recent study investigates the impact of statins on the emotional bias, a risk factor for depression. The study appears in Biological Psychiatry and was published by Elsevier.

How a particle accelerator works

Los Alamos National Lab

In early June 1972, the world’s most intense proton beam was delivered through nearly a mile of vacuum tanks at the Los Alamos Neutron Science Center, or LANSCE. As the facility has evolved over five decades, that proton beam is now delivered to five state-of-the-art experimental areas, including the Isotope Production Facility.

The Isotope Production Facility excels in the basic science and applied engineering needed to produce and purify useful isotopes that can then be produced at scale in the marketplace. In the fight against cancer, recent and current clinical trials are yielding promising results with the short-lived isotope actinium-225, which delivers high-energy radiation to a cancer tumor without greatly affecting the surrounding tissue.

‘LA-UR-22–25259′

Genetic discovery could spell mosquitoes’ death knell

A UC Riverside genetic discovery could turn disease-carrying mosquitoes into insect Peter Pans, preventing them from ever maturing or multiplying.

In 2018, UCR entomologist Naoki Yamanaka found, contrary to accepted scientific wisdom, that an important steroid hormone requires to enter or exit fruit fly cells. The hormone, ecdysone, is called the “molting hormone.” Without it, flies will never mature, or reproduce.

Before his discovery, textbooks taught that ecdysone travels freely across cell membranes, slipping past them with ease. “We now know that’s not true,” Yamanaka said.

DNA evolves at different rates, depending on chromosome structure

The structure of how DNA is stored in archaea makes a significant difference to how quickly it evolves, according to a new study by Indiana University researchers.

The study, led by molecular biologist Stephen Bell, Distinguished Professor and chair of the College of Arts and Sciences’ Department of Molecular and Cellular Biochemistry at Indiana University (IU) Bloomington, was recently published in Nature Microbiology. Its findings have the potential to impact research on the treatment of genetic diseases such as cancer.

“The most exciting thing we revealed is the idea that the shape of a DNA molecule can affect its ability to change,” Bell said. “In the early 20th century, modernist architecture had the idea that the form of a building should follow its function. But what we’re seeing in these organisms is that over time, form is actually affecting . How DNA is structured can change it, creating an evolutionary feedback loop.”

Dr. Jessica Whited, Ph.D. — Harvard University — Exploring The Biology Of Limb Regeneration

(https://hscrb.harvard.edu/labs/whited-lab/) is an Assistant Professor of Stem Cell and Regenerative Biology at Harvard University where her lab focuses on limb regeneration in axolotl salamanders and where they develop tools to manipulate gene expression during limb regeneration, and explore signaling events following wound healing that initiate the regenerative process.

Dr. Whited earned a B.A. in Philosophy and a B.S. in Biological Sciences from the University of Missouri, and obtained her Ph.D. in Biology from MIT, where she studied in Dr. Paul Garrity’s laboratory.

Dr. Whited’s thesis focused on molecular mechanisms controlling the development and maintenance of cellular architectures in the Drosophila nervous system. During this work, Dr. Whited became interested in processes that may be required long after initial developmental events to ensure cells do not revert to immature behaviors, as well as processes that provoke such events in response to injury. She worked in the laboratory of Dr. Cliff Tabin (Harvard Medical School Department of Genetics) as a postdoc studying total limb regeneration in axolotl salamanders. During this time, Whited developed several molecular tools that can be used to interrogate regenerating axolotl limbs, which is one of the core focuses of her lab today.

Dr. Whited is also Co-Founder of Matice Biosciences, a company leveraging regenerative biology for the next generation of skincare and consumer scar products.

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