It’s not often that a failed clinical trial leads to a scientific breakthrough.
When patients in the UK started showing adverse side effects during a cancer immunotherapy trial, researchers at La Jolla Institute for Immunology (LJI) Center for Cancer Immunotherapy and University of Liverpool went back through the data and worked with patient samples to see what went wrong.
Their findings, published recently in Nature, provide critical clues to why many immunotherapies trigger dangerous side effects—and point to a better strategy for treating patients with solid tumors.
Reimagining A Healthier Future for All — Dr. Pat Verduin PhD, Chief Technology Officer, Colgate, discussing the microbiome, skin and oral care, and healthy aging from a CPG perspective.
Dr. Patricia Verduin, PhD, (https://www.colgatepalmolive.com/en-us/snippet/2021/circle-c…ia-verduin) is Chief Technology Officer for the Colgate-Palmolive Company where she provides leadership for product innovation, clinical science and long-term research and development across their Global Technology Centers’ Research & Development pipeline.
Dr. Verduin joined Colgate Palmolive in 2007 as Vice President, Global R&D. Previously she served as Vice President, Scientific Affairs, for the Grocery Manufacturers Association, and from 2000 to 2006, she held the position of Vice President, Research & Development, at ConAgra Foods.
Dr. Verduin started her career with 17 years at Nabisco, serving in multiple roles, including plant manager and scientist. She earned her undergraduate degree from the University of Delaware, holds an MBA from Fairleigh Dickinson University and a PhD in Food Science from Rutgers University.
Colgate-Palmolive Company (https://www.colgatepalmolive.com/) is an American multinational consumer products company specializing in the production, distribution and provision of household, health care, personal care and veterinary products, with a mission of re-imagining a healthier future for all people, their pets and our planet.
A growing group of startups and established logistics firms have created a multi-billion-dollar industry applying artificial intelligence and other cutting-edge… See more.
LONDON, May 3 (Reuters) — Over the last two years a series of unexpected events has scrambled global supply chains. Coronavirus, war in Ukraine, Brexit and a container ship wedged in the Suez Canal have combined to delay deliveries of everything from bicycles to pet food.
In response, a growing group of startups and established logistics firms has created a multi-billion dollar industry applying the latest technology to help businesses minimize the disruption.
Interos Inc, Fero Labs, KlearNow Corp and others are using artificial intelligence and other cutting-edge tools so manufacturers and their customers can react more swiftly to supplier snarl-ups, monitor raw material availability and get through the bureaucratic thicket of cross-border trade.
In removing cilia from human pluripotent stem cells, Freedman and his colleagues sought to understand what would happen in their subsequent transformation into tissues and organoids. As it happened, the cilia-free stem cells appeared normal but were unable to fully realize new forms.
“It was surprising to me that, at a certain point after they were turning into tissues, they seemed to break down,” Freedman said. “They struggled to transform into anything sophisticated. I think one lesson from this is that the cilia help get cells through their final stage of development.”
It was first reported in 2000 that PKD could stem from defects in cilia, but the mechanism of damage that causes cysts to form has escaped scientists. By creating cilia-free stem cells that harbor disease, Freedman said, the researchers now have a framework with which to test and compare molecular actions in the cilia.
Estimates put this industry’s worth at a staggering $610 billion by 2025. 😳
The Renaissance philosopher Montaigne quipped that “death has us by the scruff of the neck at every moment.” He could have added: until, finally, it strangles us. But what if we knew how to escape death’s chokehold? What if we could avoid death and live forever?
Immortality might seem like the stuff of science fiction, yet it’s increasingly becoming the focus of real science. In 2013, Google launched Calico, a biotech firm whose objective is to “solve” death. PayPal co-founder Peter Thiel, meanwhile, has pledged to “fight” death. And last year, it was reported Amazon chairman Jeff Bezos had invested in Altos Labs, a company that plans to “rejuvenate” cells in order to “reverse disease.” (Bezos owns The Washington Post.)
Tesla Giga Shanghai has resumed over 80% production along with several other companies, according to Chinese official Zhang Hongtao — the chief engineer of the Shanghai Economics and Information Technology Commission.
China created a “whitelist” to support companies resuming production and minimize the impact of Covid along the supply chain. As of Saturday, April 30, approximately 1,854 companies have made it onto the whitelist, including Tesla, and are authorized to resume work.
During a press conference, Zhang stated that Shanghai created a second list of 1,188 companies that can resume work. According to the Global Times, the companies fall into the automobile manufacturing, equipment manufacturing, and biomedicine sector.
We still don’t know just how the first life emerged on Earth. One suggestion is that the building blocks arrived here from space; now, a new study of several carbon-rich meteorites has added weight to this idea.
Using new, extremely sensitive analysis techniques for these meteorites, a team led by scientists from Hokkaido University in Japan detected organic compounds that form the very backbone of the nucleic acid molecules common to all life as we know it – DNA and RNA.
Using new analyses, scientists have just found the last two of the five informational units of DNA and RNA that had yet to be discovered in samples from meteorites. While it is unlikely that DNA could be formed in a meteorite, this discovery demonstrates that these genetic parts are available for delivery and could have contributed to the development of the instructional molecules on early Earth. The discovery, by an international team with NASA researchers, gives more evidence that chemical reactions in asteroids can make some of life’s ingredients, which could have been delivered to ancient Earth by meteorite impacts or perhaps the infall of dust.
All DNA and RNA, which contains the instructions to build and operate every living being on Earth, contains five informational components, called nucleobases. Until now, scientists scouring extraterrestrial samples had only found three of the five. However, a recent analysis by a team of scientists led by Associate Professor Yasuhiro Oba of Hokkaido University, Hokkaido, Japan, identified the final two nucleobases that have eluded scientists.
Nucleobases belong to classes of organic molecules called purines and pyrimidines, which have a wide variety. However, it remains a mystery why more types haven’t been discovered in meteorites so far.
