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The Rise Of Genetic Engineering | Gene-Editing | Documentary

Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.

The Rise Of Genetic Engineering (2022)
Writers: Kyle McCabe, Christopher Webb Young.
Stars: Rodolphe Barrangou, George Church, Mary Beth Dallas.
Genre: Documentary.
Country: United States.
Language: English.
Release Date: August 24, 2022 (United States)

Synopsis:
Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.

Methods like this allow scientists to alter and ‘re-program’ the genetics of living organisms.

This episode shows scientists at large using gene-editing technologies to revolutionize the food supply chain, bolstering food crops to prevent famines, and even speed up reforestation efforts that will reverse global warming. Genetic Engineering in farm animals is helping scientists to ‘select’ desirable traits, like physical features and gender. Incredibly, one scientist is using gene-editing technologies to resurrect the DNA of extinct species, like the Wooly Mammoth!

Despite some public concern, gene-editing is definitely a cause for hope in the fight against genetic disorders in humans. It’s already reversing a type of congenital blindness in children. And with the hyper-precision afforded by PRIME editing being prepared for clinical trials, a much more hopeful world will be revealed for families in the future.

DNA Double Helix Splits Due to Invasive Nature of Unzipping Process

Scientists had a hard time reconstructing how complex molecular parts are being held together. However, that was before SISSA’s Cristian Micheletti and his team studied how the DNA double helix unzips when translocated at high velocity through a nanopore.

DNA Double Helix’s Unzipping

DNA has a double helix structure because it consists of two spiral chains of deoxyribonucleic acid. Its shape is reminiscent of a spiral staircase.

MIT is testing light and sound to combat Alzheimer’s

Our brains aren’t limited to producing just one type of brain wave at a time, but usually, one type is dominant, and the type it is can often be linked to your level of alertness: delta waves may dominate when you sleep, while gamma waves might dominate when you concentrate intensely.

The idea: Researchers have previously observed that people with Alzheimer’s — a devastating neurological disease affecting more than 6 million people in the US alone — may have weaker and less in-sync gamma waves than people who don’t have the disease.

In a series of past studies, MIT researchers demonstrated a deceptively simple way to increase the power and synchronization of these waves in mouse models of Alzheimer’s: expose the animals to lights flickering and/or sounds clicking at a frequency of 40 Hz.

Organoids — growing mini BRAINS

Organoids are an incredible tool for research into the brain. Cerebral organoids are created by growing human stem cells in a bioreactor. They might be the key to unlocking the answers to many of our questions about the brain. We explain how they’re made and some of the discoveries they’ve helped with so far!

✍ Script by Duranka Perera (https://www.durankaperera.com/)
✍ Thumb by “Broken” Bran — https://twitter.com/BranGSmith.

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Morag Forbes.
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Ronald Coleman Dees.
Alex Rofini.
Helen Whitley.

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What if You Give a Rat Human Brain Cells? You Can Control Its Behavior… — YouTube

Scientists transplanted human cerebral organoids (“minibrains”) into rats, to better study brain disorders. The neurons grown in vivo looked more like mature human brain cells than those grown in vitro, and they made better models of Timothy syndrome. The human minibrains formed deep connections with the rat brains, received sensory information, and drove the rat’s behavior.

More on how minibrains are grown and used, and the issue of organoid consciousness: https://www.youtube.com/watch?v=u6FGq7_t3Eo.

On the topic of organoid sentience and playing pong: https://www.youtube.com/watch?v=67r7fDRBlNc.

Support the channel: https://www.patreon.com/ihmcurious.

Sitcom music by John Bartmann: https://johnbartmann.com

Growing Mini-Brains in a Lab: Cerebral Organoids Could Save Your Life, But Has Science Gone Too Far?

Chapters:
0:00 Intro.
0:43 Growing Organoids.
2:57 Minibrains in Science & Medicine.
4:46 Giving Minibrains Psychedelics.
5:26 Minibrains With Eyes.
6:30 Can Minibrains Feel?
7:22 Looking For Consciousness.
9:03 The Future of Minibrain Research.
10:47 Human Minibrains Grafted Onto Mice.
12:10 What’s Next?

Videography by Island Fox Media.

Sound by Kutan Katas.

Patreon: https://www.patreon.com/IhmCurious.

Twitter: https://twitter.com/IhmCurious.

Music.

Inside a mini-brain (with eyes?) lab

If a free-floating brain could feel pain or ‘wake up,’ how would we know? That’s an important ethical question — and it’s one we need to ask more often as labs around the world create new organoids, or miniature human organs. To answer it we talked to Jay Gopalakrishnan at his ‘mini brain’ lab for centrosome and cytoskeleton biology in Düsseldorf, Germany.

STUDY: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00295-2

#brains #organoids #ethics #Germany #India.

More Science unscripted:

- Spotify — https://open.spotify.com/show/12TYXSLLcUf9nw7QVyBZXp.
- Apple — https://podcasts.apple.com/us/podcast/science-unscripted/id253428066
- Google — https://podcasts.google.com/feed/aHR0cHM6Ly9yc3MuZHcuY29tL3h…Y3JpcHRlZA
- Deezer: https://www.deezer.com/de/show/40077
- Amazon — https://music.amazon.co.uk/podcasts/d5edfb46-a6e2-4d31-b…unscripted.

DW science:

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