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Category: biotech/medical – Page 1,367

Scientists use machine learning to get an unprecedented view of small molecules

A new machine learning model will help scientists identify small molecules, with applications in medicine, drug discovery and environmental chemistry. Developed by researchers at Aalto University and the University of Luxembourg, the model was trained with data from dozens of laboratories to become one of the most accurate tools for identifying small molecules.

Thousands of different small molecules, known as , transport energy and transmit cellular information throughout the human body. Because they are so small, metabolites are difficult to distinguish from each other in a blood sample analysis—but identifying these molecules is important to understand how exercise, nutrition, and metabolic disorders affect well-being.

Metabolites are normally identified by analyzing their mass and retention time with a separation technique called liquid chromatography followed by mass spectrometry. This technique first separates metabolites by running the sample through a column, which results in different flow rates—or retention times—through the measurement device.

How a common cold develops

Winter and rainy season is worst for those who have low immunity. Antibiotics have many side effects. But there high fever due to viral infection is also risky.

A cold is an infection caused by a virus. It’s a common and usually mild illness that affects the nose and throat. Find out more here: http://bit.ly/KV8y1c.

The content is intended for general information only and does not replace the need for personal advice from a qualified health professional.

Origins of Rare Childhood Cancer-Like Disease Identified

Until now, some researchers believed Langerhans cell histiocytosis (LCH), a rare and fatal form of cancer in children, is derived from immune cells called dendritic cells, while others believed that they originate from related immune cells called monocytes. A new study showed mutated LCH cells have properties similar to both monocytes and dendritic cells, as well as a relatively new type of dendritic cell called DC3.

FDA Approves Gene Therapy for Tough-to-Treat Bladder Cancer

MONDAY, Dec. 19, 2022 (HealthDay News) — Patients with a high-risk bladder cancer now have a new option to treat it.

The U.S. Food and Drug Administration on Friday approved a gene therapy called Adstiladrin, which is designed to work for patients who have what’s called high-risk non-muscle-invasive bladder cancer (NMIBC) that hasn’t responded to the standard treatment, Bacillus Calmette-Guérin (BCG), but hasn’t spread. BCG is a vaccine typically used for tuberculosis.

“This approval provides health care professionals with an innovative treatment option for patients with high-risk NMIBC that is unresponsive to BCG therapy,” Dr. Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, said in an agency news release. “Today’s action addresses an area of critical need. The FDA remains committed to facilitating the development and approval of safe and effective cancer treatments.”

New FDA-Approved Eyedrops Could Improve Close-Up Vision

Dec. 14, 2021 — A new FDA-approved eyedrop medicine could replace reading glasses for millions of Americans who have age-related blurry vision.

The product, called Vuity, was approved by the FDA in October and went on the market last week. The new medicine begins working in about 15 minutes and provides sharper vision for 6 to 10 hours.

Vuity is the first FDA-approved eyedrop to treat the condition known as presbyopia, which tends to affect people ages 40 and older. The prescription drug uses the eye’s natural ability to reduce its pupil size.

Life-changing: New gene therapy gel heals decades-old wounds from skin disease

A gene therapy gel for a blistering skin disease developed at Stanford Medicine has worked wonders in a double-blind, placebo-controlled clinical trial.

The gel, called B-VEC, was intended to treat dystrophic epidermolysis bullosa, a skin disease that results in large open wounds that last for decades. The condition is extremely painful, and the medical treatment is mostly limited to palliative care.

A New Drug Could Fight Both COVID and Cancer

University of Southern California and the Cleveland Clinic Florida Research and Innovation Center researchers have published new research on GRP78, a protein implicated in both COVID-19.

First identified in 2019 in Wuhan, China, COVID-19, or Coronavirus disease 2019, (which was originally called “2019 novel coronavirus” or 2019-nCoV) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has spread globally, resulting in the 2019–22 coronavirus pandemic.

Scientists Create An Artificial Neuron That Can Be Used To Reanimate Cockroach Limbs

Scientists are getting closer to producing prosthetic limbs that can sense touch. A team of researchers from Stanford University and Seoul National University have created an artificial nerve system that can not only sense differences in pressure but also read individual Braille letters. More amazingly still, they managed to hook the artificial nerves up to the leg of a cockroach and make the limb twitch.

“We take skin for granted but it’s a complex sensing, signaling and decision-making system,” says Stanford’s Zhenan Bao, co-author of the paper published in Science and whose lab has been developing the system, in a statement. “This artificial sensory nerve system is a step toward making skin-like sensory neural networks for all sorts of applications.”

The nerve circuit that the team developed is made up of three main components.

A Key to Cancer Research: The Origin-of-Life Molecule

Researchers from Spain and Denmark have discovered a technique for attacking cancer cells in the production of one of the origin-of-life molecules.

The molecule that gave rise to life, RNA

Ribonucleic acid (RNA) is a polymeric molecule similar to DNA that is essential in various biological roles in coding, decoding, regulation and expression of genes. Both are nucleic acids, but unlike DNA, RNA is single-stranded. An RNA strand has a backbone made of alternating sugar (ribose) and phosphate groups. Attached to each sugar is one of four bases—adenine (A), uracil (U), cytosine ©, or guanine (G). Different types of RNA exist in the cell: messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA).

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