Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1330

The late 21st century belongs to Superhumans. Technological progress in the field of medicine through gene editing tools like CRISPR is going to revolutionize what it means to be human. The age of Superhumans is portrayed in many science fiction movies, but for the first time in our species history, radically altering our genome is going to be possible through the methods and tools of science.

The gene-editing tool CRISPR, short for clustered regularly interspaced short palindromic repeats, could help us to reprogram life. It gives scientists more power and precision than they have ever had to alter human DNA.

Genetic engineering holds great promise for the future of humanity. A growing number of scientists including David Sinclair believe that we will soon be able to engineer and change our genes in a way that will help us live longer and healthier lives.

But how much should we really tinker with our own nature? What is the moral responsibility of scientists and humans towards future generations?

Continue reading “The Era of Genetically Modified Superhumans” | >

If in space, no one can hear you scream, then what happens when DNA silently breaks in microgravity? Spoiler alert: it heals itself.

This is what a CRISPR experiment that won the Genes in Space 6 contest — SYFY WIRE was at the recent launch of the Genes in Space 8 experiment to the ISS — found out. DNA damage or breakage can mean the potential for degenerative diseases such as cancer, but the fact that it can also self-repair (and in microgravity!) has enormous implications for medical treatments above and below Earth’s atmosphere.

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Archaeologists have analysed DNA found in the remains of a woman who died 7,200 years ago in Indonesia — challenging previous theories around the migration of early humans.

The remains of the teenager, nicknamed Besse, were discovered in the Leang Panninge cave on Sulawesi in 2015.

It is believed to be the first time ancient human DNA has been discovered in Wallacea, a group of islands between mainland Asia and Australia.

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Two senior leaders in the US Food and Drug Administration’s vaccine review office are stepping down, even as the agency works toward high-profile decisions around Covid-19 vaccine approvals, authorizations for younger children and booster shots.

The retirements of Dr. Marion Gruber, director of the Office of Vaccines Research and Review at FDA’s Center for Biologics Evaluation and Research, and Dr. Philip Krause, deputy director of the office, were announced in an internal agency email sent on Tuesday and shared with CNN by the FDA.

In the email, CBER Director Dr. Peter Marks said Gruber will retire on October 31 and Krause is leaving in November. Marks thanked Gruber for her leadership throughout efforts to authorize and approve Covid-19 vaccines, and Krause for serving in a “key role in our interactions to address critical vaccine-related issues with our public health counterparts around the world.”

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Brent Nally interviews Dr Katcher about E5 plasma filtering. “What’s the purpose of anything if you’re gonna die?” E5 human trials perhaps by the end of 2022. All treated rats so far are still alive. “The question is how many times can we do this?” So far with rats it’s 3 times. He has not given out the specific E5 formula. Right now there is another party attempting to repeat his rat experiments.

Harold earned his PhD in Biology, is Chief Science Officer of Yuvan Research and is one of the discoverers of the breast cancer gene (BRCA1). Harold describes in his book, The Illusion of Knowledge, his personal story and journey developing E5 which may be extremely promising for the field of rejuvenation/biological age reversal. Read this May2020paper.

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Continue reading “Does E5 Reverse Aging? | Dr. Harold Katcher interview (August 2021)” | >

Circa 2015 Clues of the genetic material in vultures could give rise to humans that have immunity to nearly all bacteria and viruses.

WASHINGTON WASHINGTON (Reuters) — A diet of putrid rotting flesh may not be your cup of tea, but to the cinereous vulture, found across southern Europe and Asia, it is positively delightful. This tough bird, it turns out, is genetically wired to thrive on the stuff.

Researchers on Tuesday said they have sequenced the genome of this big scavenger, also called the Eurasian black vulture, identifying genetic traits that account for a stalwart stomach and powerful immune system that let it carry on eating carrion.

They pinpointed genetic features related to gastric acid secretion that help explain this vulture’s ability to digest carcasses and other features linked to its immune system defense against microbial and viral infections from decomposing flesh.

Continue reading “One tough bird: vulture’s genes help it thrive on rotting flesh” | >

Why not eradicate disease for everyone?

Zolgensma – which treats spinal muscular atrophy, a rare genetic disease that damages nerve cells, leading to muscle decay – is currently the most expensive drug in the world. A one-time treatment of the life-saving drug for a young child costs US$2.1 million.

While Zolgensma’s exorbitant price is an outlier today, by the end of the decade there’ll be dozens of cell and gene therapies, costing hundreds of thousands to millions of dollars for a single dose. The Food and Drug Administration predicts that by2025it will be approving 10 to 20 cell and gene therapies every year.

I’m a biotechnology and policy expert focused on improving access to cell and gene therapies. While these forthcoming treatments have the potential to save many lives and ease much suffering, health care systems around the world aren’t equipped to handle them. Creative new payment systems will be necessary to ensure everyone has equal access to these therapies.

Continue reading “New gene therapies may soon treat dozens of rare diseases, but million-dollar price tags will put them out of reach for many” | >

In order to find a way to trick the body into making new B cells, the researchers probed one of the ways that the body naturally replenishes its supply. Patients undergoing treatment for multiple sclerosis had their MBC stock depleted, at which point their body rapidly started to produce new B cells.

The team identified the specific hormones that shut B cell production down again once stores were replenished, and realized that deactivating the hormone results in the body producing extra B cells left and right. And going forward, they hope to turn that hormonal trick into a new rejuvenating treatment for the elderly and immunocompromised.

“We found specific hormonal signals produced by the old B cells, the memory cells, that inhibit the bone marrow from producing new B cells,” Melamed told The Jerusalem Post. “This is a huge discovery. It is like finding a needle in a haystack.”

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