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Category: biotech/medical – Page 1,287

New York’s Gorbunova Aging Research Center team is encouraged by frailty results from SIRT6 activator trial.

SIRT6, the so-called “longevity sirtuin” has been making rather a name for itself.

SIRT6 is a protein with an important job. It is vital for both normal base excision repair and double-strand break repair of DNA damage – damage that can lead to genomic instability, which ultimately contributing to aging. These repairs decline with age but can be boosted with SIRT6 [1].

But SIRT6 has another string to its longevity bow; back in 2019, Vera Gorbunova, professor of biology at the University of Rochester, and her team, demonstrated an overexpression of SIRT6 protein leads to extended lifespan. The researchers also showed that the opposite is also true – a deficiency in SIRT6 can cause premature aging [2].

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MPXV was first discovered during a nonfatal outbreak at an animal facility in Copenhagen, Denmark, in 1958. The facility received a continual supply of Asian monkeys (mostly M. fascicularis) and rhesus macaques (Macaca mulatta), which were used for polio vaccine research. The first outbreak occurred 2 months after the monkeys had been received and the second outbreak occurred 4 months after the initial outbreak. The outbreaks occurred in M. fascicularis that had arrived from Singapore. Upon arrival, monkeys were treated with antibiotics and appeared in satisfactory health.

Monkeypox virus (MPXV) was discovered in 1958 during an outbreak in an animal facility in Copenhagen, Denmark. Since its discovery, MPXV has revealed a propensity to infect and induce disease in a large number of animals within the mammalia class from pan-geographical locations. This finding has impeded the elucidation of the natural host, although the strongest candidates are African squirrels and/or other rodents. Experimentally, MPXV can infect animals via a variety of multiple different inoculation routes; however, the natural route of transmission is unknown and is likely to be somewhat species specific. In this review we have attempted to compile and discuss all published articles that describe experimental or natural infections with MPXV, dating from the initial discovery of the virus through to the year 2012. We further discuss the comparative disease courses and pathologies of the host species.

Keywords: aerosol, animals, infection, intrabronchial, intradermal, intramuscular, intranasal, intratracheal, intravenous, outbreak, primates, subcutaneous.

Orthopoxviruses (OPVs) have host specificities ranging from narrow (e.g., ectromelia and variola [VARV]) to broad (e.g., cowpox and vaccinia [VACV]). Monkeypox virus (MPXV) has a broad host-range and is capable of infecting many species from across the globe. In nature, the major environs of MPXV are restricted to the Congo Basin (CB) and West Africa (WA). The MPXV virion is a brick-shaped enveloped virus of 200–250 nm, characterized by surface tubules and a dumbbell-shaped core. Humans and highly susceptible nonhuman primates (NHPs) infected with MPXV have near identical clinical manifestations compared to humans infected with VARV. For humans, the only obvious difference in clinical signs is the absence of lymphadenopathy in smallpox patients [1,2].

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As most of you know I have cancer called multiple myeloma and have had it for almost a decade now. Unfortunately medical bills are staggering, especially in the US. I am asking to reach a goal of $10,000 to help wipe out if not most of my medical debt and expenses. I have over 1,000 friends on Facebook. If each friend donated $8.00 this would help me not only reach but exceed my goal. Please consider helping:

If anyone needs proof of my diagnosis or medical debt please message me.

I have outlined my journey with cancer several years ago on Lifeboat Foundation’s blog: https://lifeboat.com/blog/2018/09/83169

Hi, my name is Nicholas and I was diagnosed with multiple myeloma several years ago. Medical bills are exceedingly expensive even with insurance. I am creating content on tiktok in hopes to create an income to help me cover such costs.

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They claimed that artificial intelligence can actually solve some of the hardest challenges that affect the delivery of dementia treatment to old people, especially those with Alzheimer’s disease.

In 2021, the National Library of Medicine revealed that more than 6.2 million U.S. residents are suffering from Alzheimer’s.

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Researchers from TU Delft have constructed the smallest flow-driven motors in the world. Inspired by iconic Dutch windmills and biological motor proteins, they created a self-configuring flow-driven rotor from DNA that converts energy from an electrical or salt gradient into useful mechanical work. The results open new perspectives for engineering active robotics at the nanoscale.

The article is now published in Nature Physics (“Sustained unidirectional rotation of a self-organized DNA rotor on a nanopore”).

Rotary motors have been the powerhouses of human societies for millennia: from the windmills and waterwheels across the Netherlands and the world to today’s most advanced off-shore wind turbines that drive our green-energy future.

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Researchers have developed a new chip-based beam steering technology that provides a promising route to small, cost-effective and high-performance lidar (or light detection and ranging) systems. Lidar, which uses laser pulses to acquire 3D information about a scene or object, is used in a wide range of applications such as autonomous driving, free-space optical communications, 3D holography, biomedical sensing and virtual reality.

“Optica l beam steering is a key technology for lidar systems, but conventional mechanical-based beam steering systems are bulky, expensive, sensitive to vibration and limited in speed,” said research team leader Hao Hu from the Technical University of Denmark. “Although devices known as chip-based optical phased arrays (OPAs) can quickly and precisely steer light in a non-mechanical way, so far, these devices have had poor beam quality and a field of view typically below 100 degrees.”

In Optica, Hu and co-author Yong Liu describe their new chip-based OPA that solves many of the problems that have plagued OPAs. They show that the device can eliminate a key optical artifact known as aliasing, achieving beam steering over a large field of view while maintaining high beam quality, a combination that could greatly improve lidar systems.

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A Purdue University chemical engineer has improved upon traditional methods to produce off-the-shelf human immune cells that show strong antitumor activity, according to a paper published in the peer-reviewed journal Cell Reports.

Xiaoping Bao, a Purdue University assistant professor from the Davidson School of Chemical Engineering, said CAR-neutrophils, or chimeric antigen receptor neutrophils, and engraftable HSCs, or , are effective types of therapies for blood diseases and cancer. Neutrophils are the most abundant white cell blood type and effectively cross physiological barriers to infiltrate solid tumors. HSCs are specific progenitor that will replenish all blood lineages, including neutrophils, throughout life.

“These cells are not readily available for broad clinical or research use because of the difficulty to expand ex vivo to a sufficient number required for infusion after isolation from donors,” Bao said. “Primary neutrophils especially are resistant to genetic modification and have a short half-life.”

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