Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1,283

We might be amidst a chip shortage, but if you enjoy reverse-engineering, there’s never a shortage of intriguing old chips to dig into – and the 2513N 5×7 character ROM is one such chip. Amidst a long thread probing a few of these (Twitter, ThreadReader link), [TubeTime] has realized that two address lines were shorted inside of the package. A Twitter dopamine-fueled quest for truth has led them to try their hand at making the chip work anyway. Trying to clear the short with an external PSU led to a bond wire popping instead, as evidenced by the ESD diode connection disappearing.

A dozen minutes of sandpaper work resulted in the bare die exposed, making quick work of the bond wires as a side effect. Apparently, having the bond pads a bit too close has resulted in a factory defect where two of the pads merged together. No wonder the PSU wouldn’t take that on! Some X-acto work later, the short was cleared. But without the bond wires, how would [TubeTime] connect to it? This is where the work pictured comes in. Soldering to the remains of the bond wires has proven to be fruitful, reviving the chip enough to continue investigating, even if, it appears, it was never functional to begin with. The thread continued on with comparing ROMs from a few different chips [TubeTime] had on hand and inferences on what could’ve happened that led to this IC going out in the wild.

Such soldering experiments are always fun to try and pull off! We rarely see soldering on such a small scale, as thankfully, it’s not always needed, but it’s a joy to witness when someone does IC or PCB microsurgery to fix factory defects that render our devices inoperable before they were even shipped. Each time that a fellow hacker dares to grind the IC epoxy layers down and save a game console or an unidentified complex board, the world gets a little brighter. And if you aren’t forced to do it for repair reasons, you can always try it in an attempt to build the smallest NES in existence!

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A team of scientists at Tufts University and Harvard University “have brought us a step closer to the goal of regenerative medicine” by using a drug cocktail to regrow a frog’s amputated legs.

Peer-reviewed study: https://www.science.org/doi/10.1126/sciadv.abj2164

Scientists say they have been able to help frogs regrow their legs for the first time. The next step? Try the procedure on mammals.

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He’s backing a new biotech company working on “cellular rejuvenation programming.”

It sure looks like Jeff Bezos has plans to cheat death.

The founder and former CEO of Amazon has reportedly made an investment in the freshly launched Altos Labs, a biotech startup focused on “cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine,” according to a January 19 press release. With $3 billion in backing on day one, Altos Labs has hit the ground running with what may be the single largest funding round for a biotech company, according to the Financial Times of London.

Altos Labs has an impressive roster of executives that includes experts formerly of GlaxoSmithKline, a health care company in the United Kingdom that primarily develops pharmaceuticals and vaccines; Genentech, a San Francisco-based biotech firm that created the first targeted antibody for cancer; and the National Cancer Institute. The quest to cheat death is as old as life itself, but this is an especially pedigreed bunch to take on the challenge.

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Xenotransplantation To Save And Extend Lives — Dr. David K.C. Cooper, MD, PhD, Massachusetts General Hospital, Harvard Medical School

Dr. David K. C. Cooper, MA, PhD, MD, MS, DSc (Med), FRCS, FACS, FACC, FAST, (https://researchers.mgh.harvard.edu/profile/27073950/David-Cooper) is a pioneering heart transplant surgeon and researcher in the field of xenotransplantation, which is defined as any procedure that involves the transplantation, implantation or infusion into a human recipient of live cells, tissues, or organs from a nonhuman animal source.

Dr. Cooper studied medicine in the UK at Guy’s Hospital Medical School (now part of King’s College London), and trained in general and cardiothoracic surgery in Cambridge and London.

Between 1972 and 1980, Dr. Cooper was a Fellow and Director of Studies in Medical Sciences at Magdalene College, Cambridge. In 1980 he took up an appointment in cardiac surgery at the University of Cape Town where, under Professor Christiaan Barnard, he had responsibility for patients undergoing heart transplantation.

In 1987, Dr. Cooper relocated to the Oklahoma Transplantation Institute in the USA where he continued to work in both the clinical and research fields.

Continue reading “Dr. David K. C. Cooper, MD, PhD. — MGH/Harvard — Xenotransplantation To Save And Extend Lives” | >

The COVID-19 pandemic brought about a seismic shift in the way organizations and offices operate. Working from home has become a preferred option for countless businesses and millions of employees around the globe. The work from home trend might continue in the future too, as it has proven not to affect business productivity adversely. Additionally, as per a McKinsey study, up to 278 business executives plan to reduce their office space by 30% even beyond the pandemic. Work from home is a seemingly viable option for employees for a variety of reasons, one of them being the possible arrival of the metaverse, a concept that will make traveling to a specific location for work redundant. This will affect one particular part of employees’ personal lives—domestic chores. There are more than a few reasons why IoT for smart cities and homes will play a significant role in optimizing household chores.

Domestic chores are an unavoidable yet necessary part of individuals’ personal lives. For instance, tasks such as cooking meals, managing laundry work and making timely lighting and plumbing repairs are hard to overlook, even if an important virtual business meeting is going on. In simple words, tasks such as cooking, cleaning, maintenance and task management act as distractions that stand in the way of remote organizational work. Resultantly, the productivity of remote employees is seriously affected by domestic chores. To state the obvious, remote working blurs the boundaries between the workspace and personal life. Work hours increasingly blend into the time that would normally be associated with completing household tasks. These are remote working problems that you probably know. The biggest problem of remote working is how it has regressed gender equality and the involvement of women in prominent positions at the workplace.

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Ground squirrels spend the end of summer gorging on food, preparing for hibernation. They need to store a lot of energy as fat, which becomes their primary fuel source underground in their hibernation burrows all winter long.

While hibernating, ground squirrels enter a state called torpor. Their metabolism drops to as low as just 1 percent of summer levels and their body temperature can plummet to close to freezing. Torpor greatly reduces how much energy the animal needs to stay alive until springtime.

That long fast comes with a downside: no new input of protein, which is crucial to maintain the body’s tissues and organs. This is a particular problem for muscles.

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When the results of his study came in, Kondwani Jambo was stunned.

He’s an immunologist in Malawi. And last year he had set out to determine just how many people in his country had been infected with the coronavirus since the pandemic began.

Jambo, who works for the Malawi-Liverpool-Wellcome Trust Clinical Research Programme, knew the total number of cases was going to be higher than the official numbers. But his study revealed that the scale of spread was beyond anything he had anticipated — with a huge majority of Malawians infected long before the omicron variant emerged. “I was very shocked,” he says.

So to fill in the true picture, Jambo and his collaborators turned to another potential source of information: a repository of blood samples that had been collected from Malawians month after month by the national blood bank. And they checked how many of those samples had antibodies for the coronavirus. Their finding: By the start of Malawi’s third COVID-19 wave with the delta variant last summer, as much as 80% of the population had already been infected with some strain of the coronavirus.

New findings from Malawi suggest the country has entered something akin to the endemic stage of the pandemic — along with many other African nations.

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New technologies have considerably improved scientists’ ability to locate the genetic variations that distinguish our DNA from that of other people. In some instances, these genetic differences give rise to diverse superhuman abilities. There is growing interest in identifying genes associated with special abilities, many of which seem to be inherited. Some consider people like Wim Hof a.k.a the iceman known for the Wim Hof method as a person with superhuman abilities.

As for the future, according to prominent scientists within 30 years, it will probably be possible to make essentially any kind of change to any kind of genome.

#superhuman #science #sciencetime.

Sources:
Supergenes — https://arep.med.harvard.edu/gmc/protect.html.

George Church — Genetic Superpowers: Changing Your Genome and Environment, Harvard Medical School.

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