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Engineers discover new process for synthetic material growth, enabling soft robots that grow like plants

An interdisciplinary team of University of Minnesota Twin Cities scientists and engineers has developed a first-of-its-kind, plant-inspired extrusion process that enables synthetic material growth. The new approach will allow researchers to build better soft robots that can navigate hard-to-reach places, complicated terrain, and potentially areas within the human body.

The paper is published in the Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed, multidisciplinary, high-impact scientific journal.

“This is the first time these concepts have been fundamentally demonstrated,” said Chris Ellison, a lead author of the paper and professor in the University of Minnesota Twin Cities Department of Chemical Engineering and Materials Science. “Developing new ways of manufacturing are paramount for the competitiveness of our country and for bringing new products to people. On the robotic side, robots are being used more and more in dangerous, remote environments, and these are the kinds of areas where this work could have an impact.”

Scientists Have Built Artificial Neurons That Fully Mimic Human Brain Cells

Circa 2015 face_with_colon_three


Researchers have built the world’s first artificial neuron that’s capable of mimicking the function of an organic brain cell — including the ability to translate chemical signals into electrical impulses, and communicate with other human cells.

These artificial neurons are the size of a fingertip and contain no ‘living’ parts, but the team is working on shrinking them down so they can be implanted into humans. This could allow us to effectively replace damaged nerve cells and develop new treatments for neurological disorders, such as spinal cord injuries and Parkinson’s disease.

“Our artificial neuron is made of conductive polymers and it functions like a human neuron,” lead researcher Agneta Richter-Dahlfors from the Karolinska Institutet in Sweden said in a press release.

Preparing for the BF-7 COVID-19 variant and flu season

PITTSBURGH (KDKA) — Move over, BA-4 and BA-5, there’s a new COVID-19 variant that’s spreading even as the push is on for the current round of boosters.

The word from the experts is to get the booster and don’t let your guard down. KDKA’s John Shumway spoke with CBS News medical expert Dr. David Agus — and some of what he had to say is a bit disconcerting.

Alpha, Beta, Gamma, Delta, Omicron, BA-4, BA-5, and now comes BF-7.

New Infectious Threats Are Coming. The U.S. Probably Won’t Contain Them

There needs to be a radical change to biological wetware in order to handle viruses. What is needed is either nanoparticles or an immunity to all diseases. Crispr is the main path for the biological singularity but it needs to be perfected first as the human body is still a black box due to restrictions. I do believe that mass spectrometry will essentially be key to see the inner world of human biology. Then crispr can make new parts essentially to evolve past our current limits. But either way the biological singularity is needed for survival of human beings for better health.


The coronavirus revealed flaws in the nation’s pandemic plans. The spread of monkeypox shows that the problems remain deeply entrenched.

Jennifer Garrison, Buck Institute | Reframing Health and Aging through the Lens of Reproduct

Foresight Biotech & Health Extension Meeting sponsored by 100 Plus Capital.
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Jennifer Garrison, Buck Institute.
Reframing Health and Aging through the Lens of Reproduct.

Jennifer Garrison is an assistant professor at the Buck Institute for Research on Aging and also holds appointments in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco (UCSF) and the Davis School of Gerontology at the University of Southern California. During her doctoral studies at UCSF with Jack Taunton, she discovered the molecular target of a natural product and elucidated a novel mechanism by which small molecules can regulate protein biogenesis.

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Towards the interpretability of deep learning models for multi-modal neuroimaging: Finding structural changes of the ageing brain

Brain-age (BA) estimates based on deep learning are increasingly used as neuroimaging biomarker for brain health; however, the underlying neural features have remained unclear. We combined ensembles of convolutional neural networks with Layer-wise Relevance Propagation (LRP) to detect which brain features contribute to BA. Trained on magnetic resonance imaging (MRI) data of a population-based study (n = 2,637, 18–82 years), our models estimated age accurately based on single and multiple modalities, regionally restricted and whole-brain images (mean absolute errors 3.37–3.86 years). We find that BA estimates capture ageing at both small and large-scale changes, revealing gross enlargements of ventricles and subarachnoid spaces, as well as white matter lesions, and atrophies that appear throughout the brain. Divergence from expected ageing reflected cardiovascular risk factors and accelerated ageing was more pronounced in the frontal lobe. Applying LRP, our study demonstrates how superior deep learning models detect brain-ageing in healthy and at-risk individuals throughout adulthood.

Analysis: Eisai’s trial success raises hope for Alzheimer’s prevention

CHICAGO, Sept 30 (Reuters) — Clear evidence this week that Eisai (4523.T) and Biogen’s (BIIB.O) drug lecanemab slows cognitive decline in early stage dementia has galvanized efforts among Alzheimer’s researchers toward a tantalizing goal — preventing dementia even before symptoms start.

Lecanemab is an antibody that targets and removes toxic clumps of a protein called amyloid beta that accumulate in the brains of patients with Alzheimer’s. Results from the companies’ 1,800-patient trial released on Tuesday showed convincingly that doing so also slows the advance of the mind-robbing disease.

In volunteers with mild cognitive impairment and early stage dementia, the drug showed a 27% reduction in cognitive decline after 18 months compared with those who got a placebo.

Scientists Discover That Chromosomes Are Fluid

Researchers from CNRS, the Curie Institute, and Sorbonne University have successfully physically acted on chromosomes in live cells for the first time. They found that, outside of cell division phases, chromosomes are actually very fluid—almost liquid—by subjecting to different forces using magnets. The study was recently published in the prestigious journal Science.

When they are not in their division phases, chromosomes are fluid, though not quite liquid. This discovery was made possible by the first-ever direct mechanical manipulation of chromosomes in the nucleus of live cells.

Previously, chromosomes, which are extraordinarily long DNA.

Chemical That Helps Cancer Grow And Spread By Disarming Immune System Identified

When cancer develops in the body, it begins with tumor cells that rapidly multiply and divide before spreading. But how are these nascent tumor cells able to evade the body’s immune system, which is designed to recognize and defend against such faulty cells? The answer to this long-unsolved topic may hold the key to more successful cancer treatments — medications that block tumors’ subversive moves and allow the immune system to do its job.

Researchers at Harvard Medical School have now discovered a mechanism through which tumor cells can disable the immune system, enabling the tumor to spread unchecked. The study, which was conducted primarily in mice and published today in Science, demonstrates that tumor cells with a certain mutation generate a chemical, known as a metabolite, that weakens adjacent immune cells, making them less capable of eliminating cancer cells.

The results underscore the crucial roles played by tumor metabolites in the deactivation of the immune system by malignancies. The findings also highlight the crucial part that the tumor microenvironment—the region around the tumor—plays in the development of cancer.

‘Love Hormone’ Oxytocin Could Mend a Broken Heart

Summary: Oxytocin, a hormone connected with bonding and love, could help to heal damage following a heart attack. Researchers found oxytocin stimulates stem cells from the heart’s outer layer and migrates into the middle layer where it develops into muscle cells that generate heart contractions. This could be used to promote the regeneration of heart cells following a heart attack.

Source: Frontiers.

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.