Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 1030

Basically the United States has alerts for the west Nile as it seems to be spreading across many states.

As temperatures warm, US health officials are braced for rising rates of West Nile virus, a disease transmitted by mosquitoes that can cause meningitis, paralysis, and death.

Oklahoma reported its first West Nile death of the year on Thursday, in a resident who had been hospitalized with the illness.

In 2021, eight people got sick and one died of West Nile virus in Oklahoma, according to the US Centers for Disease Control and Prevention. The virus often infects people without causing symptoms, but can be deadly if it reaches the brain.

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As space travel for recreational purposes is becoming a very real possibility, there could come a time when we are travelling to other planets for holidays, or perhaps even to live. Commercial space company Blue Origin has already started sending paying customers on sub-orbital flights. And Elon Musk hopes to start a base on Mars with his firm SpaceX.

This means we need to start thinking about what it will be like to live in space – but also what will happen if someone dies there.

After death here on Earth the human body progresses through a number of stages of decomposition. These were described as early as 1,247 in Song Ci’s The Washing Away of Wrongs, essentially the first forensic science handbook.

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Scientists will soon begin a clinical trial for a new liver disease treatment. The experimental treatment will hopefully help treat end-stage liver disease and reduce liver transplants. To do this, it will harness the natural regenerative power of the liver by growing an entirely new liver within the patient. It won’t just rely on one new liver, either. Instead, patients will grow multiple tiny livers in their bodies.

The process, which has shown success in mice, pigs, and dogs, involves injecting healthy liver cells into the patient’s lymph nodes. The cells then multiply inside the patient’s body, growing into tiny functioning versions of the larger organ. It’s an intriguing treatment for liver disease, and so far, it has improved liver function in animals that have received the treatment.

The clinical trial focuses on using the lymph nodes in the patients to create bioreactors that can grow the new livers. Not only would this give people dealing with liver disease more options, but it would also relieve pressure on an already overloaded transplant system. New Atlas reports that the participants will be divided into three primary groups.

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An unusual protein structure known as a “rippled beta sheet,” first predicted in 1953, has now been created in the laboratory and characterized in detail using X-ray crystallography.

The new findings, published in July in Chemical Science, may enable the rational design of unique materials based on the rippled sheet architecture.

“Our study establishes the rippled beta sheet layer configuration as a motif with general features and opens the road to structure-based design of unique molecular architectures, with potential for materials development and ,” said Jevgenij Raskatov, associate professor of chemistry and biochemistry at UC Santa Cruz and corresponding author of the paper.

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The skin is one of the largest and most accessible organs in the human body, but penetrating its deep layers for medicinal and cosmetic treatments still eludes science.

Although there are some remedies—such as nicotine patches to stop smoking—administered through the skin, this method of treatment is rare since the particles that penetrate must be no larger than 100 nanometers. Creating effective tools using such tiny particles is a great challenge. Because the particles are so small and difficult to see, it is equally challenging to determine their exact location inside the body—information necessary to ensure that they reach intended target tissue. Today such information is obtained through invasive, often painful, biopsies.

A novel approach, developed by researchers at Bar-Ilan University in Israel, provides an innovative solution to overcoming both of these challenges. Combining techniques in nanotechnology and optics, they produced tiny (nanometric) diamond particles so small that they are capable of penetrating skin to deliver medicinal and cosmetic remedies. In addition, they created a safe, laser-based optical method that quantifies nanodiamond penetration into the various layers of the skin and determines their location and concentration within body tissue in a non-invasive manner—eliminating the need for a biopsy.

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A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus—a finding that could lead to improved cancer diagnosis and treatment. Their findings were recently published in the Proceedings of the National Academy of Sciences.

DNA damage happens naturally in and most of the damage can be repaired by the cell itself. However, unsuccessful repair could lead to cancer.

“DNA in the nucleus is always moving, not static. The motion of its high-order complex, chromatin, has a direct role in influencing DNA repair,” said Jing Liu, an assistant professor of physics in the School of Science at IUPUI. “In yeast, past research shows that DNA damage promotes chromatin motion, and the high mobility of it also facilitates the DNA repair. However, in human cells this relationship is more complicated.”

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The infrared (IR) spectrum is a vast information landscape that modern IR detectors tap into for diverse applications such as night vision, biochemical spectroscopy, microelectronics design, and climate science. But modern sensors used in these practical areas lack spectral selectivity and must filter out noise, limiting their performance. Advanced IR sensors can achieve ultrasensitive, single-photon level detection, but these sensors must be cryogenically cooled to 4 K (−269 C) and require large, bulky power sources making them too expensive and impractical for everyday Department of Defense or commercial use.

DARPA’s Optomechanical Thermal Imaging (OpTIm) program aims to develop novel, compact, and room-temperature IR sensors with quantum-level performance – bridging the performance gap between limited capability uncooled thermal detectors and high-performance cryogenically cooled photodetectors.

“If researchers can meet the program’s metrics, we will enable IR detection with orders-of-magnitude improvements in sensitivity, spectral control, and response time over current room-temperature IR devices,” said Mukund Vengalattore, OpTIm program manager in DARPA’s Defense Sciences Office. “Achieving quantum-level sensitivity in room-temperature, compact IR sensors would transform battlefield surveillance, night vision, and terrestrial and space imaging. It would also enable a host of commercial applications including infrared spectroscopy for non-invasive cancer diagnosis, highly accurate and immediate pathogen detection from a person’s breath or in the air, and pre-disease detection of threats to agriculture and foliage health.”

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A multi-institute research team led by BGI-Research has used BGI Stereo-seq technology to construct the world first spatiotemporal cellular atlas of the axolotl (Ambystoma mexicanum) brain development and regeneration, revealing how a brain injury can heal itself. The study was published as a cover story in the latest issue of Science.

The research team analyzed the development and regeneration of salamander brain, identified the key neural stem cell subsets in the process of salamander brain regeneration, and described the reconstruction of damaged neurons by such stem cell subsets. At the same time, the team also found that brain regeneration and development have certain similarities, providing assistance for cognitive brain structure and development, while offering new directions for research and treatment of the nervous system.

In contrast to mammals, some vertebrates have the ability to regenerate multiple organs, including parts of the central nervous system. Among them, the axolotl can not only regenerate organs such as limbs, tail, eyes, skin and liver, but also the brain. The axolotl is evolutionarily advanced compared to other teleost, such as zebrafish, and its brain features a higher similarity to mammalian brain structure. Therefore, this study used the axolotl as an ideal model organism for research into brain regeneration.

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