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Speculation on 3D printed tissue coming to humans sooner than we think is backed by new pre-clinical findings from 3D bioprinting company Organovo (NASDAQ: ONVO). Though it will still be 3 – 5 years before the U.S. based Organovo apply for clearance of their liver tissue, that is still sooner than perhaps even the FDA had in mind.

Pre-clinical trial data shows that 3D bioprinted liver tissue has been successfully planted into lab-bred mice. The human liver-cell tissue shows regular functionality and, at this stage, is being explored as a suitable patch for the organ.

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There’s really no sector in the United States (or much of the world) that has been untouched by the development of advanced manufacturing technologies – and no one seems to be underestimating the importance of the further development of those technologies in order to keep the country competitive. To that end, in 2014 the government established the National Network for Manufacturing Innovation (NNMI), more commonly known as Manufacturing USA.

The program brought together the industrial, academic, nonprofit and governmental sectors to establish a network of advanced manufacturing institutes for the purpose of accelerating new manufacturing technologies. President Obama proposed that the network grow to 45 institutes over the course of 10 years, and as of today, 12 have been established. The 12th, which was just announced by the Department of Defense, will be the Advanced Tissue Biofabrication (ATB) Manufacturing USA Institute, and will be led by the Advanced Regenerative Manufacturing Institute (ARMI), based in Manchester, New Hampshire.

“The investments we are making in advanced manufacturing, including today’s announcement, will ensure that the innovations needed to develop, manufacture and commercialize cutting-edge processes and materials will happen right here, in America,” said Defense Secretary Ash Carter. “They will provide important benefits to our war fighters and will help strengthen the economy that is the bedrock of our national security.”

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Bioprinting has been all over the news in the past several years with headline-worthy breakthroughs like printed human skin, synthetic bones, and even a fully functional mouse thyroid gland.

3D printing paved the way for bioprinting thanks to the printers’ unique ability to recreate human tissue structures; their software can be written to ‘stack’ cells in precise patterns as directed by a digital model, and they can produce tissue in just hours and make numerous identical samples.

Despite the progress in bioprinting, however, more complex human organs continue to elude scientists, and resting near the top of the ‘more complex’ list are the kidneys.

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A woman living on a dialysis machine is grown a new kidney using her own cells. A father struggling with age-related vision loss has his eyesight restored. A soldier suffers extensive burns and has his skin regenerated.

This is a glimpse of the holy grail of regenerative medicine. The ultimate goal of the field is to develop therapies that restore normal function to diseased tissues and organs. Advances in 3D bioprinting, the process of fabricating functional human tissue outside the body in a layer-by-layer fashion, have pushed the envelope on what is considered possible in the field.

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Humanized organs in gene-edited animals is one potential way medicine can deal with the demand for transplant organs.


One potential avenue for research and to help solve the organ shortage is to modify animals to be closer matched to humans in order to have organs capable of being used for transplant. This short paper is an interesting primer into the subject and touches upon the technical and ethical concerns involved here.

It is one possible solution to the problem, however, 3D bioprinting increases in sophistication and other methods are also being developed that would render this approach needless. Still this is an interesting insight into regenerative medicine and one possible path research might take.

#LifespanIO #aging #crowdfundthecure

http://www.futuremedicine.com/doi/10.2217/rme-2016-0096

South Korean-based company Rokit is a 3D printing manufacturer we’ve talked about on several occasions before. In February this year, they released Edison Invivo, a tissue engineering and bio-medical research 3D printer that uses a bio ink to produce cell structures in the form of organic tissue.

Now, as a constant innovator, Rokit is back with their latest and also the world first Multi-Use Hybrid Bio 3D printer — Rokit Invivo. What’s exciting is that this awesome bioprinter will be revealed very soon on 30th, September in the Digical Show held by London-based iMakr.

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