Lifeboat Foundation

The idea of terraforming Mars is a fascinating idea. … But just how long would such an endeavor take, what would it cost us, and is it really an effective use of our time and energy?

Ultimately, Yakovlev thinks that space biospheres could also be accomplished within a reasonable timeframe – i.e. between 2030 and 2050 – which is simply not possible with terraforming. Citing the growing presence and power of the commercial space sector, Yakovlev also believed a lot of the infrastructure that is necessary is already in place (or under development).

Continue reading “The future of space colonization – terraforming or space habitats?” »

Circa 2011

There is a physical and electrical disconnect between the world of electronics and the world of biology. Electronics tend to be rigid, operate using electrons, and are inherently two-dimensional. The brain, as a basis for comparison, is soft, operates using ions, and is three-dimensional. Researchers have therefore been looking to find different routes to create biocompatible devices that work well in wet environments like biological systems. In an exiting new development, researchers from North Carolina State University have fabricated a memory device that is soft, entirely based on liquid-based matter, and functions well in wet environments — opening the door to a new generation of biocompatible electronic devices.

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Researchers at the Department of Energy’s Oak Ridge National Laboratory used neutron scattering to identify key information to improve the effectiveness of drug inhibitors designed to block the virus’s replication mechanism. The research is published in the Journal of Biological Chemistry.

The SARS-CoV-2 virus, which causes the COVID-19 disease, expresses long chains of proteins composed of approximately 1,900 amino acid residues. For the virus to reproduce, those chains have to be broken down and cut into smaller strands by an enzyme called the main protease. The active protease enzyme is formed from two identical protein molecules held together by hydrogen bonds. Developing a drug that inhibits or blocks the protease activity will prevent the virus from replicating and spreading to other cells in the body.

The discovery puts a nail in the coffin of a long-held assumption about the limits of where the essential process can occur.

The result is a science park and university campus that offers degrees at all levels. It hosts more than 300 labs and advanced research equipment, such as the SOLEIL synchrotron. About 100 companies and 6 of France’s public research organizations, including the national research agency CNRS, have a presence there. That combination — of the university with national facilities — is powerful, says Price. The park accounts for an estimated 15% of France’s public and private research. About 30,000 people work or study at Saclay, and this is projected to rise to 80,000 by 2030.

The lab has no overall scientific project, and has added an extra layer of management, says Fayard, although he concedes that the coronavirus pandemic has complicated the lab’s first months. “I fear the lab will have to work hard not to fall between two stools — it is too big to be efficient, but not big enough to invest alone in major local infrastructures.”

But Oliver Brüning, a particle physicist at CERN, Europe’s particle physics lab near Geneva, Switzerland, who spent time working at LAL, says he thinks the new lab has greater weight and influence than did LAL alone.

Continue reading “How France overcame the odds to build a research mega-campus” »

Here’s my latest video!

Calorie restriction (CR) is well known to extend average and maximal lifespan in a variety of animal models, but what about in people? In this video, I present evidence showing that CR slows biological aging, which suggests that CR will positively affect lifespan in people.

The great powerful guppy can essentially evolve 10 million times faster than usual. Which could lead to humans evolving faster too leading to a biological singularity.

Although natural selection is often viewed as a slow pruning process, a dramatic new field study suggests it can sometimes shape a population as fast as a chain saw can rip through a sapling. Scientists have found that guppies moved to a predator-free environment adapted to it in a mere 4 years—a rate of change some 10,000 to 10 million times faster than the average rates gleaned from the fossil record. Some experts argue that the 11-year study, described in today’s issue of Science,* may even shed light on evolutionary patterns that occur over eons.

A team led by evolutionary biologist David Reznick of the University of California, Riverside, scooped guppies from a waterfall pool brimming with predators in Trinidad’s Aripo River, then released them in a tributary where only one enemy species lurked. In as little as 4 years, male guppies in the predator-free tributary were already detectably larger and older at maturity when compared with the control population; 7 years later females were too. Guppies in the safer waters also lived longer and had fewer and bigger offspring.

Continue reading “Guppy Evolution Fast Forwards” »

Chemists studying how life started often focus on how modern biopolymers like peptides and nucleic acids contributed, but modern biopolymers don’t form easily without help from living organisms. A possible solution to this paradox is that life started using different components, and many non-biological chemicals were likely abundant in the environment. A new survey conducted by an international team of chemists from the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology and other institutes from Malaysia, the Czech Republic, the U.S. and India, has found that a diverse set of such compounds easily form polymers under primitive environmental conditions, and some even spontaneously form cell-like structures.

Understanding how life started on Earth is one of the most challenging questions modern science seeks to explain. Scientists presently study modern organisms and try to see what aspects of their biochemistry are universal, and thus were probably present in the organisms from which they descended. The best guess is that life has thrived on Earth for at least 3.5 billion of Earth’s 4.5-billion-year history since the planet formed, and most scientists would say life likely began before there is good evidence for its existence. Problematically, since Earth’s surface is dynamic, the earliest traces of life on Earth have not been preserved in the geological record. However, the earliest evidence for life on Earth tells us little about what the earliest organisms were made of, or what was going on inside their cells. “There is clearly a lot left to learn from prebiotic chemistry about how life may have arisen,” says the study’s co-author Jim Cleaves.

A hallmark of life is evolution, and the mechanisms of evolution suggest that common traits can suddenly be displaced by rare and novel mutations which allow mutant organisms to survive better and proliferate, often replacing previously common organisms very rapidly. Paleontological, ecological and laboratory evidence suggests this occurs commonly and quickly. One example is an invasive organism like the dandelion, which was introduced to the Americas from Europe and is now a commo weed causing lawn-concerned homeowners to spend countless hours of effort and dollars to eradicate.

Summary: A mutation in a gene associated with circadian rhythm extends the clock period, causing people to stay up late at night and sleep late in the mornings.

Source: UC Santa Cruz

A new study by researchers at UC Santa Cruz shows how a genetic mutation throws off the timing of the biological clock, causing a common sleep syndrome called delayed sleep phase disorder.