Lifeboat Foundation

The behavior of one of nature’s humblest creatures is helping astronomers probe the largest structures in the universe.

The single-cell organism, known as slime mold (Physarum polycephalum), builds complex filamentary networks in search of food, finding near-optimal pathways to connect different locations. In shaping the universe, gravity builds a vast cobweb structure of filaments tying galaxies and clusters of galaxies together along faint bridges hundreds of millions of light-years long. There is an uncanny resemblance between the two networks: one crafted by biological evolution, and the other by the primordial force of gravity.

The cosmic web is the large-scale backbone of the cosmos, consisting primarily of the mysterious substance known as dark matter and laced with gas, upon which galaxies are built. Dark matter cannot be seen, but it makes up the bulk of the universe’s material. The existence of a web-like structure to the universe was first hinted at in the 1985 Redshift Survey conducted at the Harvard-Smithsonian Center for Astrophysics. Since those studies, the grand scale of this filamentary structure has grown in subsequent sky surveys. The filaments form the boundaries between large voids in the universe.

Even since Alexander Fleming stumbled across penicillin—the first antibiotic drug—scientists knew our fight with evolution was on.

Most antibiotics work by blocking biological processes that allow bacteria to thrive and multiply. With prolonged, low-dosage use, however, antibiotics become a source of pressure that forces bacteria to evolve—and because these microorganisms are extremely adept at swapping and sharing bits of their DNA, when one member becomes resistant, so does most of its population.

Continue reading “CRISPR Pill May Be Key in Fight Against Antibiotic Resistance” »

Nematic superconductivity with spontaneously broken rotation symmetry has recently been reported in doped topological insulators, M x Bi 2 Se 3 (M = Cu, Sr, Nb). Here we show that the electromagnetic (EM) response of these compounds provides a spectroscopy for bosonic excitations that reflect the pairing channel and the broken symmetries of the ground state. Using quasiclassical Keldysh theory, we find two characteristic bosonic modes in nematic superconductors: the nematicity mode and the chiral Higgs mode. The former corresponds to the vibrations of the nematic order parameter associated with broken crystal symmetry, while the latter represents the excitation of chiral Cooper pairs. The chiral Higgs mode softens at a critical doping, signaling a dynamical instability of the nematic state towards a new chiral ground state with broken time reversal and mirror symmetry. Evolution of the bosonic spectrum is directly captured by EM power absorption spectra. We also discuss contributions to the bosonic spectrum from subdominant pairing channels to the EM response.

We’ve been expecting aliens from Mars for decades now, but what if life was vanquished on the red planet before evolution ever got the chance to take hold?

A pair of researchers recently published an analysis of 3.5 billion-years-old soil samples from Mars containing chemical compounds called “thiophenes” that could, potentially, be organic. If they are, it would be highly likely that bacteria once lived on the planet.

Terrestrial thiophenes are considered tell-tale signs of life by Earthbound biologists. The presence of these possibly-organic compounds in Martian soil represents the strongest evidence yet that life may have once existed anywhere other than Earth.

Humans and rodents have similar brain structures that regulate empathy, suggesting the behavior is deeply rooted in mammal evolution.

If there was a public vote about human gene enhancement, would you vote YES or NO?

Our species is on the cusp of a revolution that will change every aspect of our lives but we’re hardly talking about it.

Continue reading “Our Genetic Future Is Coming… Faster Than We Think” »

Scientists at Uppsala University have proposed an addition to the theory of evolution that can explain how and why genes move on chromosomes. The hypothesis, called the SNAP Hypothesis, is presented in the scientific journal PLOS Genet ics.

Life originated on Earth almost 4 billion years ago and diversified into a vast array of species. How did this diversification occur? The Theory of Evolution, together with the discovery of DNA and how it replicates, provide an answer and a mechanism. Mutations in DNA occur from generation to generation, and can be selected if they help individuals to adapt better to their environment. Over time, this has led to the separation of organisms into the different species that now inhabit all ecosystems.

Current theory holds that evolution involves mistakes made when replicating a gene. This explains how genes can mutate over time and acquire new functions. However, a mystery in biology is that the relative locations of genes on chromosomes also change over time. This is obvious in bacteria, as different species often have the same genes in very different relative locations. Since the origin of life, genes have apparently been changing location. The questions are, how and why do genes move their relative locations?

Domestic cats exhibit abundant variations in tail morphology and serve as an excellent model to study the development and evolution of vertebrate tails. Cats with shortened and kinked tails were first recorded in the Malayan archipelago by Charles Darwin in 1868 and remain quite common today in Southeast and East Asia. To elucidate the genetic basis of short tails in Asian cats, we built a pedigree of 13 cats segregating at the trait with a founder from southern China and performed linkage mapping based on whole genome sequencing data from the pedigree. The short-tailed trait was mapped to a 5.6 Mb region of Chr E1, within which the substitution c. 5T C in the somite segmentation-related gene HES7 was identified as the causal mutation resulting in a missense change (p. V2A). Validation in 245 unrelated cats confirmed the correlation between HES7-c. 5T C and Chinese short-tailed feral cats as well as the Japanese Bobtail breed, indicating a common genetic basis of the two. In addition, some of our sampled kinked-tailed cats could not be explained by either HES7 or the Manx-related T-box, suggesting at least three independent events in the evolution of domestic cats giving rise to short-tailed traits.

The majority of vertebrate species, with the remarkable exceptions of humans and apes, possess a visible tail throughout their lifespans. The animal tail is an important appendage to the torso and plays adaptive roles in locomotion, balance, communication, thermoregulation and even energy storage¹. In vertebrates, tails vary dramatically in color, size, shape and mobility and represent different evolutionary histories, including multiple independent events of shortening or loss of the tail in distinct lineages. Understanding the genetic causes of intraspecific tail length polymorphism would be one essential step toward elucidating the mechanisms underlying the development and evolution of tails. In laboratory mice, genetic studies of axial skeleton development have identified multiple genes and mutations involved in caudal vertebra development that have pleiotropic effects on fertility, somitogenesis, and meiotic recombination, thus shedding light on vertebrate evolution^2,3,4,5.

In 2016, the European Space Agency announced a call for medium-size missions within their Cosmic Vision Program. In layman’s terms, “medium-size” means moderate-cost (less than 550 million euros, or $610 million) and low-risk, and this is achieved by keeping payloads small and by using proven, heritage technology for both spacecraft and payload. Alongside these common-sense conditions is a third and less tangible quality, that the project be scientifically robust. But when comparing excellent cases from vastly different fields, the merits of one scientific mission over another can seem subjective. It’s not enough to lament the dearth of data in said field, or to establish how a project will discover this or that, or even to show exactly how said “groundbreaking technology” will work. ESA wants a mission that will stir up an unprecedented level of excitement, support, and interest within the scientific community. Here is how they attempt to measure a project’s relevance.

“Each member state has a representative in the Science Programme Committee, and it’s their duty to define the content of the program,” said Luigi Colangeli, head of ESA’s Science Coordination Office. “Study groups work with the various proposals to arrive at something that is compatible with the boundary conditions, in this case, of a M-5, or medium-class mission. Right now, we are studying the evolution of the three missions. And then next year we will put together a peer review panel, who will analyze the three candidates and recommend the best selection to our Director of Science.”

Since the call went out four years ago, ESA have been whittling down proposals, from 25 at the beginning to only three now: Envision, Theseus, or SPICA. In February the EnVision conference took place at the National Centre for Space Studies (CNES) in Paris. EnVision is a low-altitude polar orbiter that is meant to perform high-resolution radar mapping, surface composition, and atmospheric studies of Venus. The purpose of the meeting was to call the Venus community to attention, because the clock is ticking. Consortium members, ESA representatives, and interested scientists from all over the world were in attendance.