Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: evolution

Myeloproliferative Neoplasms

Classic myeloproliferative neoplasms, including essential thrombocythemia, polycythemia vera, and primary myelofibrosis, are chronic, clonal hematopoietic stem-cell disorders. These disorders are driven by gain-of-function mutations in the genes Janus kinase 2 (JAK2), calreticulin (CALR), or the thrombopoietin receptor (MPL) that activate cytokine signaling. These mutations arise decades before clinical disease develops and confer a clonal advantage that is further shaped by comutations in epigenetic, splicing, or signaling genes. Inflammation enhances clonal dominance, favoring the development of myelofibrosis and thrombotic complications. Disease evolution may culminate in secondary acute myeloid leukemia, which has a poor prognosis.

New Monte Carlo method accelerates simulations of densely entangled polymer melts

Long polymer chains are everywhere: in synthetic materials, soft matter, biological systems such as chromosomes, and mathematical models of filaments and knots. When many such chains are densely packed, they form what physicists call a polymer melt. In this crowded environment, each chain is constrained by the others around it. These entanglements are central to the behavior of polymeric materials, but they also make the systems extremely difficult to simulate. As chain length increases, the time needed to obtain a new independent configuration grows very rapidly. For very large systems, conventional simulations can therefore become computationally prohibitive.

For more than 70 years, scientists have used many “tricks” to speed up this process, including so-called Monte Carlo methods with ingenious moves designed to accelerate the evolution of the system. These methods helped, but the basic problem remained: In a dense melt, changes still had to propagate through a highly tangled system, slowing down the simulation.

New measurements explain how silicon and diamond achieve extreme reversible stretching

A research team led by Yang Lu from the Department of Mechanical Engineering at the Faculty of Engineering, The University of Hong Kong (HKU), has uncovered the microscopic physical nature of ultralarge elasticity in covalent semiconductors such as silicon and diamond. The discovery provides quantitative guidance for deep elastic strain engineering (DESE), paving the way for the development of next-generation electronic, optoelectronic and quantum devices.

Despite the potential of DESE, the underlying deformation mechanisms of these covalent crystals have long remained elusive. The research team was the first to directly observe the pure lattice evolution of single-crystal silicon and diamond under tension at the atomic scale.

By precisely quantifying the resulting lattice strains, the researchers bridged macroscopic mechanical strain with microscopic lattice strain, establishing a physical foundation for the design of advanced semiconductor devices. The research team also includes PhD student Jiayi Li and postdoctoral fellow Dr. Heyi Wang.

Rethinking how we name and classify our human ancestors following recent evolutionary discoveries

Recent advances in our understanding of human evolution challenge the way we currently name and classify our ancestors, according to new research from Monash University. The study, published in the American Journal of Biological Anthropology, argues that we need a rethink and proposes reclassifying all species of humans and our closely related fossil relatives that have lived in the past 4–5 million years as part of the genus Homo.

Stellar stream beyond Milky Way offers new tool to map dark matter

In the image above, a faint trail of stars can be seen stretching across the galaxy. These structures, known as globular cluster stellar streams, are coherent stellar structures that retain a record of their dynamical history and can provide unique insights into the evolution of galaxies and the nature of dark matter.

Globular cluster stellar streams offer astronomers a unique opportunity to map otherwise invisible dark matter and study how it behaves. For many years, they have been difficult to observe because they are extremely faint. However, advances in large astronomical data sets and sophisticated analysis techniques have recently made stellar streams one of the most promising tools in galactic astronomy.

Now, Ph.D. student Julie Kiel Holm from the Niels Bohr Institute and associate professor Sarah Pearson from DTU Space, together with an international team of researchers, have made a discovery that has never been seen before. Their findings have just been published in Nature.

A Human-Specific Gene May Help Explain Our Extraordinary Brainpower

The new findings could help explain what made the human brain unique during evolution.

A mouse’s brain immune cells mature in about three weeks. Their human counterparts take four to eight years, an unusually slow timetable that may help explain how the human brain develops its distinctive cognitive abilities.

Microglia are the brain’s most abundant immune cells. They protect against invading threats, remove damaged neurons and help shape neural circuits as the brain develops. Scientists at Columbia’s Zuckerman Institute have now found for the first time that human microglia, like human neurons, mature far more slowly than those of other animals.

Lost Primal Eye Paradigm scientific review and update August 2026

A growing body of research across paleoneurology, evolutionary biology, and chronobiology now supports the core mechanisms of Steve Nichols’s Lost Primal Eye paradigm aka Median Vision Theory (MVT). This is a regular scientific review and update posted for The Posthuman University Journal on academia.edu August 2026 Palaeoneurology and Therapsid Evolution Benoit et al. (2016) (Acta Palaeontologica Polonica): Examined over 800 therapsid fossil skulls, documenting the convergent, gradual reduction and complete loss of the parietal foramen across Permo-Triassic eutheriodonts. The study directly links the degeneration of the physical pineal eye to the evolution of mammalian endothermy, nocturnal adaptation, and the transfer of photoreception to paired lateral eyes.

Astronomers catch massive galaxy assembling piece by piece 1.2 billion years after Big Bang

Astronomers have discovered a remarkably tiny group of six young galaxies just 1.2 billion years after the Big Bang. This may be a rare glimpse of how some of the universe’s largest galaxies formed. The paper outlining the findings was submitted to the arXiv preprint server on July 13.

Chaotic patches The widely accepted cosmological model of the universe known as the Lambda Cold Dark Matter Model suggests that galaxies primarily form hierarchically through mergers. That means they grow piece by piece, as smaller galaxies merge over billions of years. In this context, dense regions in the early universe serve as natural laboratories to test this idea.

These dense patches, known as protoclusters and proto-groups, are young clusters of galaxies packed into a region just tens of thousands of light-years across and represent an especially brief and extreme stage in galaxy evolution. Spotting them requires telescopes sensitive enough to detect faint, low-mass galaxies at extreme distances, and precise enough to confirm that the galaxies are truly bound together.

Cells share universal on switches but evolve unique strategy to silence genes

The signals that cells use to switch genes on have remained almost unchanged across two billion years of evolution, but the ones used to switch genes off vary dramatically from one branch of life to another, according to a new study from the Centre for Genomic Regulation (CRG) in Barcelona.

Reversal of protein chemical aging by enzymatic deglycation

et al. used an innovative series of screening and directed evolution steps to produce a new enzyme (CMLase) which can remove a pernicious form of advanced glycation end product (AGE) linkage from proteins. AGEs contribute to biological aging, so CMLase may possess therapeutic potential to combat parts of the aging process.

Advanced glycation end products (AGEs) in proteins, a hallmark of aging, are considered irreversible. Here, authors report the development of CMLase — an enzyme that specifically oxidizes Nε-carboxymethyl-lysine (CML) and restores the native lysine residues in vitro and in human tissue samples.

/* */