Bioengineers and tissue engineers intend to reconstruct skin equivalents with physiologically relevant cellular and matrix architectures for basic research and industrial applications. Skin pathophysiology depends on skin-nerve crosstalk and researchers must therefore develop reliable models of skin in the lab to assess selective communications between epidermal keratinocytes and sensory neurons.
In a new report now published in Nature Communications, Jinchul Ahn and a research team in mechanical engineering, bio-convergence engineering, and therapeutics and biotechnology in South Korea presented a three-dimensional, innervated epidermal keratinocyte layer on a microfluidic chip to create a sensory neuron-epidermal keratinocyte co-culture model. The biological model maintained well-organized basal-suprabasal stratification and enhanced barrier function for physiologically relevant anatomical representation to show the feasibility of imaging in the lab, alongside functional analyses to improve the existing co-culture models. The platform is well-suited for biomedical and pharmaceutical research.
Skin: The largest sensory organ of the human body
Skin is composed of a complex network of sensory nerve fibers to form a highly sensitive organ with mechanoreceptors, thermoreceptors and nociceptors. These neuronal subtypes reside in the dorsal root ganglia and are densely and distinctly innervated into the cutaneous layers. Sensory nerve fibers in the skin also express and release nerve mediators including neuropeptides to signal the skin. The biological significance of nerves to sensations and other biological skin functions have formed physical and pathological correlations with several skin diseases, making these instruments apt in vivo models to emulate skin-nerve interactions.
Scientists at the Max Planck Institute have developed a synthetic pathway that can capture CO2 from the air more efficiently than in nature, and shown how to implement it into living bacteria. The technique could help make biofuels and other products in a sustainable way.
Plants are famous for their ability to convert carbon dioxide from the air into chemical energy to fuel their growth. With way too much CO2 in the atmosphere already and more being blasted out every day, it’s no wonder scientists are turning to this natural process to help rein levels back in, while producing fuels and other useful molecules on the side.
In the new study, Max Planck scientists developed a brand new CO2-fixation pathway that works even better than nature’s own tried-and-true method. They call it the THETA cycle, and it uses 17 different biocatalysts to produce a molecule called acetyl-CoA, which is a key building block in a range of biofuels, materials and pharmaceuticals.
A nice talk. At 18 minutes dude says healthspan is way more important than lifespan. Never mind that large sign behind him that says lifespan. But, not to knock it too much, yes healthspan is important too.
I believe nanomachines or new advanced rna antivirals that can target one’s own variants of viruses will be game changers to prevent future global pandemics. Also eventually new genetic engineering could allow for the end to all viruses with some sorta Omni vaccine.
Measurement(s) Pandemic-and epidemic-prone disease outbreaks Technology Type(s) Text mining using R Sample Characteristic — Organism Disease outbreaks Sample Characteristic — Environment spatiotemporal region Sample Characteristic — Location Global.
In this new episode Steven sits down with the physician and longevity expert, Dr Peter Attia. 0:00 Intro 03:26 What is your mission? 06:52 Medicine 3.0 14:51 When should we really think about diseases? 23:14 What role does trauma play in longevity? 47:24 The 5 health deterioration 50:16 Proof exercise is important 01:04:48 Body deterioration can be slowed down 01:08:38 How much exercise should we be doing? 01:14:03 The importance of stability 01:20:59 We’ve engineered discomfort out of our lives 01:26:29 Sugar 01:34:16 Misconceptions about weight loss 01:45:13 Alcohol 01:49:13 Sleep 01:52:35 Hormone replacement therapy 01:57:07 Hair loss 01:59:48 The last guests question You can purchase Dr Attia’s new book, ‘Outlive: The Science and Art of Longevity’, here — https://amzn.to/3FUD6ok Follow Dr Attia: Instagram: https://bit.ly/3rBMyJ7 Twitter: https://bit.ly/44DkrYF YouTube: https://bit.
An interview with J. Storrs Hall, author of the epic book “Where is My Flying Car — A Memoir of Future Past”: “The book starts as an examination of the technical limitations of building flying cars and evolves into an investigation of the scientific, technological, and social roots of the economic…
J. Storrs Hall or Josh is an independent researcher and author.
He was the founding Chief Scientist of Nanorex, which is developing a CAD system for nanomechanical engineering.
His research interests include molecular nanotechnology and the design of useful macroscopic machines using the capabilities of molecular manufacturing. His background is in computer science, particularly parallel processor architectures, artificial intelligence, particularly agoric and genetic algorithms.
Resurrection biology — attempting to bring strings of molecules and more complex organisms back to life — is gaining traction in labs around the world.
The work is a far cry from the genetically engineered dinosaurs that escape in the blockbuster movie “Jurassic Park,” although for some scientists the ultimate goal is de-extinction and resurrecting animals and plants that have been lost.
Other researchers are looking to the past for new sources of drugs or to sound an alarm about the possibility of long-dormant pathogens. The field of study is also about recreating elements of human history in an attempt to better understand how our ancestors might have lived and died.
The Genetic Revolution is a compelling science documentary that invites viewers into the groundbreaking world of DNA manipulation and genetic engineering. This intriguing documentary showcases the innovative science behind genetic modifications and chronicles a diverse team of scientists from around the world as they utilize advanced DNA editing technologies like CRISPR in ways previously deemed unthinkable.\
With its exploration into the rapidly evolving science of DNA editing, \.
Feng Guo, an associate professor of intelligent systems engineering at the Indiana University Luddy School of Informatics, Computing and Engineering, is addressing the technical limitations of artificial intelligence computing hardware by developing a new hybrid computing system—which has been dubbed “Brainoware”—that combines electronic hardware with human brain organoids.
Advanced AI techniques, such as machine learning and deep learning, which are powered by specialized silicon computer chips, expend enormous amounts of energy. As such, engineers have designed neuromorphic computing systems, modeled after the structure and function of a human brain, to improve the performance and efficiency of these technologies. However, these systems are still limited in their ability to fully mimic brain function, as most are built on digital electronic principles.
In response, Guo and a team of IU researchers, including graduate student Hongwei Cai, have developed a hybrid neuromorphic computing system that mounts a brain organoid onto a multielectrode assay to receive and send information. The brain organoids are brain-like 3D cell cultures derived from stem cells and characterized by different brain cell types, including neurons and glia, and brain-like structures such as ventricular zones.
