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The model can help evolve “better methods for growing cells for blood transfusions, novel cell therapies, and hematopoietic stem cell transplants.”


Remarkably, heX-Embryoid models developed structures akin to blood islands, the initial sites supporting the generation of blood cells in developing embryos. The study identified progenitors for red blood cells, platelets, and various white blood cell types—a pivotal advancement in the field, according to the team.

Researchers claim the model successfully replicated a process closely resembling the initial stages of blood production in humans. “This is exciting because there are extensive possibilities to apply this model to better understand how blood is formed and develop better methods for growing cells for blood transfusions, novel cell therapies, and hematopoietic stem cell transplants,” said Mo Ebrahimkhani, senior author and an associate professor at the Pittsburgh Liver Institute and the Department of Bioengineering at Pitt, in a statement.

Versatile characteristics

A new Seattle biotech organization will be funded to the tune of $75 million to research “DNA typewriters,” self-monitoring cells that could upend our understanding of biology. The collaboration between the University of Washington, the Chan-Zuckerberg Initiative and the Allen Institute is already underway.

Called the Seattle Hub for Synthetic Biology, the joint initiative will combine the expertise of the two well-funded research outfits with that of UW Medicine, working in what UW’s Jay Shendure, scientific lead for the project, called “a new model of collaboration.”

The Hub (not to be confused with the HUB, or Husky Union Building, on UW’s campus) aims to strike a balance between a disinterested intellectual academic approach and a development-focused commercial approach. The $75 million will fund the organization for five years, with the option to renew then.

Good telescope that I’ve used to learn the basics: https://amzn.to/35r1jAk.
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Hello and welcome! My name is Anton I’m away for a few days due to voice issues, so enjoy this older video where we talk about the incredible invention of 3D printed bio ink that could be used to print any biological tissue (in theory). 3D printed heart anyone?

Links:
https://www.nature.com/articles/s41467-021-26791-x.
https://www.mdpi.com/2072-666X/12/8/865
https://www.sciencedaily.com/releases/2021/09/210921134345.htm.
https://en.wikipedia.org/wiki/Fibrin.

Bladder grown from 3D bioprinted tissue continues to function after 14 years


https://www.ascb.org/science-news/bioprinting-ethical-and-societal-implications/
Biocomputing: https://youtu.be/nszcPNhYRzI
Artificial cell: https://youtu.be/0MRGJNKACYs.
Synthethic genome: https://youtu.be/OxVZPKmm58M
0:00 History of 3D printing organs.
2:00 Why this is important for medical studies.
2:45 Bioink invention.
3:40 How this works.
5:30 Results from the study are quite incredible.
6:30 Future of medical 3D printing.

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Target validation is a crucial step in pre-clinical drug discovery workflows that builds confidence on the identification of a genetic target as relevant to a disease. With recent advancements, CRISPR serves as a particularly powerful tool for this process, as it enables researchers to accurately modify genes and determine their function in a variety of experimental systems.

One scientist leveraging CRISPR gene editing in this way is Dr. Panos Zalmas, Head of the Open Targets Validation Lab based at the Wellcome Sanger Institute, whose work focuses on discovering and validating new putative disease targets for the development of safe and effective medicines.

In this SelectScience® interview, we speak with Zalmas to learn how he is working to improve the rate of target adoption into drug discovery pipelines across therapy areas such as oncology, neurodegeneration, and immunology and inflammation. Here, Zalmas explains the importance of gene editing in his target validation workflows and highlights how CRISPR technologies in particular are key to the success of drug discovery.