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Category: bioengineering – Page 215

Hope for HIV patients.

In 2014, a team of researchers in the Lewis Katz School of Medicine at Temple University became the first to successfully eliminate the HIV-1 virus from cultured human cells. Fewer than two years later, the team has made further strides in its research by eliminating the virus from the genome of human T-cells using the specialized gene editing system they designed.

In a new study published in Scientific Reports, the researchers show that the method can both effectively and safely eliminate the virus from the DNA of human cells grown in culture.

How this research differs In previous work, the team—led by Kamel Khalili, professor and chair of the Department of Neuroscience at Temple—had demonstrated the ability of their technology to snip out HIV-1 DNA from normal human cells. The newest findings used that same technology to snip out the virus from latently and productively infected CD4+ T-cells, which host the virus in persons infected with HIV.

Continue reading “Scientists prove effectiveness of gene editing system in eliminating HIV from DNA of CD4+ T-cells” | >

Next time you go for a brain scan; you could actually see dissolvable electrodes.

Hmmm

Scientists at the University of Pennsylvania in a study funded by the Defense Advance Research Projects Agency (DARPA) are developing implantable electrodes for brain monitoring that melt away at a predetermined rate. The devices could come in handy for monitoring and treating certain neurophysiological disorders such as Parkinson’s, depression and chronic pain.

The electrodes, which are made from layers of silicon and a chemical element, molybdenum, dissolve at a known rate according to thickness. The devices can provide “continuous streams of data for guiding medical care over predetermined periods of time,” Brian Litt, senior co-author on the study and a professor of neurology, neurosurgery and bioengineering at UPenn, said in a statement.

Continue reading “DARPA-backed researchers create dissolvable electrodes for brain monitoring” | >

Samsung get into the cancer treatment space with their own Q-Dot technology? Another reason for the FDA to show up in tech’s backyard; lookout for all those future federal and state regs & compliance training that will be coming that eats up 20 hours each month of your scientists and engineering talent’s time.

For a lot of users, Samsung might be known best for their smartphones and other mobile devices, but the company is so much more than that. Many of you reading this might have one of Samsung’s Super HD TV sets, a curved Samsung TV or some other model of theirs. Next to smartphones one of their more popular consumer electronics is of course of TVs, and with the advent of new technology such as Quantum Dot, Samsung is getting even better at producing a great image. One area that you might expect to find this Quantum Dot technology being used is for medical uses, but that’s just what researchers have been exploring recently.

Explaining a Quantum Dot can become quite tricky, but to cut a long story short, they are semiconductors that are so small they register at the nanoscale side of things. In terms of Quantum Dots used in television displays, it’s their ability to precisely tune to a specific and exact part of the color spectrum that makes them so attractive, not to mention their much lower power draw. Now, Kim Sung-jee, a professor of the Chemistry department at Pohang University of Science and Technology (POSTECH), has said that “when combining protein which clings to cancer cells and quantum dots, it can be used to seek out cancer cells in the body”. It’s reasoned that the potential for these Quantum Dots to be so precise in terms of color reproduction can help physicians track down certain cancer cells.

Myung Seung-jae, chief director of Biomedical Research Center at Asan Institute for Life Sciences who joined Professor Kim in researching Quantum Dots to fight cancer, said that when a test was ran on animals with Cancer cells in their bodies drugs with Quantum Dots “attacked only cancer cells. When quantum dots meet cancer cells, they detect the change of potential of hydrogen (pH) and anti-cancer drugs”. So, while it seems a long way off, it looks like the same technology that makes for a more accurate and engaging picture for your TV could be used in order to fight cancer or at least better identify types of Cancer and how to combat them inside of the body.

Continue reading “Samsung’s Quantum Dot TV Tech to Find Medical Applications” | >

A study performed at IRB Barcelona offers an explanation as to why the genetic code stopped growing 3,000 million years ago. This is attributed to the structure of transfer RNAs—the key molecules in the translation of genes into proteins. The genetic code is limited to 20 amino acids—the building blocks of proteins—the maximum number that prevents systematic mutations, which are fatal for life. The discovery could have applications in synthetic biology.

Nature is constantly evolving—its limits determined only by variations that threaten the viability of species. Research into the origin and expansion of the are fundamental to explain the evolution of life. In Science Advances, a team of biologists specialised in this field explain a limitation that put the brakes on the further development of the genetic code, which is the universal set of rules that all organisms on Earth use to translate genetic sequences of nucleic acids (DNA and RNA) into the that comprise the proteins that undertake cell functions.

Headed by ICREA researcher Lluís Ribas de Pouplana at the Institute for Research in Biomedicine (IRB Barcelona) and in collaboration with Fyodor A. Kondrashov, at the Centre for Genomic Regulation (CRG) and Modesto Orozco, from IRB Barcelona, the team of scientists has demonstrated that the genetic code evolved to include a maximum of 20 and that it was unable to grow further because of a functional limitation of transfer RNAs—the molecules that serve as interpreters between the language of genes and that of proteins. This halt in the increase in the complexity of life happened more than 3,000 million years ago, before the separate evolution of bacteria, eukaryotes and archaebacteria, as all organisms use the same code to produce proteins from genetic information.

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Neurons created from chemically induced neural stem cells. The cells were created from skin cells that were reprogrammed into neural stem cells using a cocktail of only nine chemicals. This is the first time cellular reprogramming has been accomplished without adding external genes to the cells. (credit: Mingliang Zhang, PhD, Gladstone Institutes)

Scientists at the Gladstone Institutes have used chemicals to transform skin cells into heart cells and brain cells, instead of adding external genes — making this accomplishment a breakthrough, according to the scientists.

The research lays the groundwork for one day being able to regenerate lost or damaged cells directly with pharmaceutical drugs — a more efficient and reliable method to reprogram cells and one that avoids medical concerns surrounding genetic engineering.

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Now, that’s an exhibit!

May 5, 2016, will mark the opening of a new and exciting exhibit at Chicago’s famed Museum of Science and Industry: an in-depth and interactive look behind the curtain at the Defense Advanced Research Projects Agency (DARPA).

DARPA was created in 1958 at the peak of the Cold War in response to the Soviet Union’s launch of Sputnik, the world’s first manmade satellite, which passed menacingly over the United States every 96 minutes. Tasked with preventing such strategic surprises in the future, the agency has achieved its mission over the years in part by creating a series of technological surprises of its own, many of which are highlighted in the Chicago exhibit, “Redefining Possible.”

“We are grateful to Chicago’s Museum of Science and Industry for inviting us to tell the DARPA story of ambitious problem solving and technological innovation,” said DARPA Deputy Director Steve Walker, who will be on hand for the exhibit’s opening day. “Learning how DARPA has tackled some of the most daunting scientific and engineering challenges—and how it has tolerated the risk of failure in order to have major impact when it succeeds—can be enormously inspiring to students. And for adults, we hope the exhibit will serve as a reminder that some of the most exciting work going on today in fields as diverse as chemistry, engineering, cyber defense and synthetic biology are happening with federal support, in furtherance of pressing national priorities.”

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Excellent read and a true point about the need for some additional data laws with our ever exploding information overload world.

Laws for Mobility, IoT, Artificial Intelligence and Intelligent Process Automation

If you are the VP of Sales, it is quite likely you want and need to know up to date sales numbers, pipeline status and forecasts. If you are meeting with a prospect to close a deal, it is quite likely that having up to date business intelligence and CRM information would be useful. Likewise traveling to a remote job site to check on the progress of an engineering project is also an obvious trigger that you will need the latest project information. Developing solutions integrated with mobile applications that can anticipate your needs based upon your Code Halo data, the information that surrounds people, organizations, projects, activities and devices, and acting upon it automatically is where a large amount of productivity gains will be found in the future.

There needs to be a law, like Moore’s infamous law, that states, “The more data that is collected and analyzed, the greater the economic value it has in aggregate.” This law I believe is accurate and my colleagues at the Center for the Future of Work, wrote a book titled Code Halos that documents evidence of its truthfulness as well. I would also like to submit an additional law, “Data has a shelf-life and the economic value of data diminishes over time.” In other words, if I am negotiating a deal today, but can’t get the critical business data I need for another week, the data will not be as valuable to me then. The same is true if I am trying to optimize, in real-time, the schedules of 5,000 service techs, but don’t have up to date job status information. Receiving job status information tomorrow, does not help me optimize schedules today.

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Scientists are now one step closer to neutralizing HIV.

In a study conducted at Vanderbilt University and published in Proceedings of the National Academy of Sciences, researchers isolated antibodies with a loop-like structure that binds tightly to HIV and disables it. Unlike traditional vaccines, which jump-start an immune response by exposing the patient to a pathogen, this newly discovered method could work even in people who have not previously been exposed to by the virus.

Using computer modeling, the researchers identified the amino acid sequences that bound most tightly to HIV and re-engineered them in an optimal sequence that simulated vaccination.

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