Lifeboat Foundation: Safeguarding Humanity
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Category: bioengineering – Page 120

Chemical process called ELAST allows labeling probes to infuse more quickly, and makes samples tough enough for repeated handling.

When there’s a vexing problem to be solved, people sometimes offer metaphorical advice such as “stretching the mind” or engaging in “flexible” thinking, but in confronting a problem facing many biomedical research labs, a team of MIT researchers has engineered a solution that is much more literal. To make imaging cells and molecules in brain and other large tissues easier while also making samples tough enough for years of handling in the lab, they have come up with a chemical process that makes tissue stretchable, compressible, and pretty much indestructible.

“ELAST” technology, described in a new paper in Nature Methods, provides scientists a very fast way to fluorescently label cells, proteins, genetic material, and other molecules within brains, kidneys, lungs, hearts, and other organs. That’s because when such tissues can be stretched out or squished down thin, labeling probes can infuse them far more rapidly. Several demonstrations in the paper show that even after repeated expansions or compressions to speed up labeling, tissues snap back to their original form unaltered except for the new labels.

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Genetic engineering and other advanced technologies may need to come into play if people want to live in Mars.

Last month’s NASA and SpaceX successful launch of astronauts from US soil for the first time in almost a decade, has reignited discussion about space travel to Mars and beyond. SpaceX is fronted by the billionaire Elon Musk.

Sky News reports:

Having completed its first human launch, SpaceX’s founder and chief executive Elon Musk says the company is now focusing on developing its next-generation spacecraft Starship …

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Although many animals have evolved intrinsic transparency for the purpose of concealment, the development of dynamic, that is, controllable and reversible, transparency for living human cells and tissues has remained elusive to date. Here, by drawing inspiration from the structures and functionalities of adaptive cephalopod skin cells, we design and engineer human cells that contain reconfigurable protein-based photonic architectures and, as a result, possess tunable transparency-changing and light-scattering capabilities. Our findings may lead to the development of unique biophotonic tools for applications in materials science and bioengineering and may also facilitate an improved understanding of a wide range of biological systems.

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Here’s What You Need To Remember: Chinese so-called “carrier-killer” missiles could, quite possibly, push a carrier back to a point where its fighters no longer have range to strike inland enemy targets from the air. The new drone is being engineered, at least in large measure, as a specific way to address this problem. If the attack distance of an F-18, which might have a combat radius of 500 miles or so, can double — then carrier-based fighters can strike targets as far as 1000 miles away if they are refueled from the air.

The Navy will choose a new carrier-launched drone at the end of this year as part of a plan to massively expand fighter jet attack range and power projection ability of aircraft carriers.

The emerging Navy MQ-25 Stingray program, to enter service in the mid-2020s, will bring a new generation of technology by engineering a first-of-its-kind unmanned re-fueler for the carrier air wing.

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“Properties that have never been found in nature”

New claims that the novel coronavirus SARS-CoV-2 was engineered have been dismissed by scientific and intelligence experts.

The authors of a British-Norwegian vaccine study—accepted by the Quarterly Review of Biophysics—claim that the coronavirus’s spike protein contains sequences that appear to be artificially inserted.

In their paper, the Norwegian scientist Birger Sørensen and British oncologist Angus Dalgleish claim to have identified “inserted sections placed on the SARS-CoV-2 spike surface” that explains how the virus interacts with cells in the human body. Virologists, however, note that similar sections appear naturally in other viruses.

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A team of scientists from Stanford University is working with researchers at the Molecular Foundry, a nanoscience user facility located at the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab), to develop a gene-targeting, antiviral agent against COVID-19.

Last year, Stanley Qi, an assistant professor in the departments of bioengineering, and chemical and at Stanford University and his team had begun working on a technique called PAC-MAN—or Prophylactic Antiviral CRISPR in —that uses the gene-editing tool CRISPR to fight influenza.

But that all changed in January, when news of the COVID-19 pandemic emerged. Qi and his team were suddenly confronted with a mysterious new virus for which no one had a clear solution. “So we thought, ‘Why don’t we try using our PAC-MAN technology to fight it?’” said Qi.

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Scientists have successfully transplanted functional miniature livers into rats, after growing the bioengineered organs in the lab from reprogrammed human skin cells.

The experiment, which gave the animals working liver organs, could lay the groundwork for future treatments to address terminal liver failure – a disease that claims the lives of over 40,000 people in the US every year.

While there’s still a lot of work to be done before the technique can directly aid human patients, the researchers say their proof of concept may help underpin a future alternative to liver transplants, which are often incredibly expensive procedures to perform, in addition to being strictly limited by donor supply.

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