Lifeboat Foundation

INDIANAPOLIS (WISH) — First is was monkeys, then dogs.

Now, researchers are turning to cows in hopes of developing a treatment for the coronavirus.

Scientists at SAb Biotherapeutics in South Dakota created an embryo via genetic engineering that contains human chromosomes. The embryo was then implanted into cattle. The cows gave birth to calves that internally function similarly to a person, specifically with regards to the human immune system.

Then there is the COVID-19 Open Research Dataset (CORD-19), a multi-institutional initiative that includes The White House Office of Science and Technology Policy, Allen Institute for AI, Chan Zuckerberg Initiative (CZI), Georgetown University’s Center for Security and Emerging Technology (CSET), Microsoft, and the National Library of Medicine (NLM) at the National Institutes of Health (NIH).

The goal of this initiative is to create new natural language processing and machine learning algorithms to scour scientific and medical literature to help researchers prioritize potential therapies to evaluate for further study. AI is also being used to automate screening at checkpoints by evaluating temperature via thermal cameras, as well as modulations in sweat and skin discoloration. What’s more, AI-powered robots have even been used to monitor and treat patients. In Wuhan, the original epicenter of the pandemic, an entire field hospital was transitioned into a “smart hospital” fully staffed by AI robotics.

Any time of great challenge is a time of great change. The waves of technological innovation that are occurring now will echo throughout eternity. Science, technology, engineering and mathematics are experiencing a call to mobilization that will forever alter the fabric of discovery in the fields of bioengineering, biomimicry and artificial intelligence. The promise of tomorrow will be perpetuated by the pangs of today. It is the symbiosis of all these fields that will power future innovations.

In an effort to create first-of-kind microelectronic devices that connect with biological systems, University of Maryland (UMD) researchers are utilizing CRISPR technology in a novel way to electronically turn “on” and “off” several genes simultaneously. Their technique, published in Nature Communications, has the potential to further bridge the gap between the electronic and biological worlds, paving the way for new wearable and “smart” devices.

“Faced with the COVID-19 pandemic, we now have an even deeper understanding of how ‘smart’ devices could benefit the general population,” said William E. Bentley, professor in UMD’s Fischell Department of Bioengineering and Institute for Bioscience and Biotechnology Research (IBBR), and director of the Robert E. Fischell Institute for Biomedical Devices. “Imagine what the world would be like if we could wear a device and access an app on our smartphone capable of detecting whether the wearer has the active virus, generated immunity, or has not been infected. We don’t have this yet, but it is increasingly clear that a suite of technologies enabling rapid transfer of information between biology and electronics is needed to make this a reality.”

With such a device, this information could be used, for example, to dynamically and autonomously conduct effective contact tracing, Bentley said.

Circa 2019.

Gain of function research was heavily debated amidst many CDC mishaps. It was stopped, and then outsourced to China due to lax regulations. Now we have an outbreak that no one can confirm it’s origin, but the epicenter is in close proximity to a Wuhan lab working on the same pathogen, with direct bat to human transmission.

Knowing this, this story disturbs me, as we have no international protocols and regulations to prevent mishaps. The last thing we need is a lab mishap, and monkeys riding on horses with guns, all pissed off at humans. We are already experiencing the Contagion movie, and biblical plagues like locusts, the last we need is planet of the apes.

Continue reading “Scientists are making human-monkey hybrids in China” »

Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Dr. Robert Hariri, MD, PhD, surgeon, bio-medical scientist and highly successful serial entrepreneur in two technology sectors: bio-medicine and aerospace.

Dr. hariri utilizes biomedicine to aid human longevity:

Continue reading “Dr Robert Hariri Talks of Using Stem Cell Therapies for Human Health and Aging” »

Circa 2016 o,.o.

It is possible large, winged dragons could be created using cutting-edge genome editing, academics have suggested.

Scientists have recently explored the unique properties of nonlinear waves to facilitate a wide range of applications including impact mitigation, asymmetric transmission, switching and focusing. In a new study now published on Science Advances, Bolei Deng and a team of research scientists at Harvard, CNRS and the Wyss Institute for Biologically Inspired Engineering in the U.S. and France harnessed the propagation of nonlinear waves to make flexible structures crawl. They combined bioinspired experimental and theoretical methods to show how such pulse-driven locomotion could reach a maximum efficiency when the initiated pulses were solitons (solitary wave). The simple machine developed in the work could move across a wide range of surfaces and steer onward. The study expanded the variety of possible applications with nonlinear waves to offer a new platform for flexible machines.

Flexible structures that are capable of large deformation are attracting interest in bioengineering due to their intriguing static response and their ability to support elastic waves of large amplitude. By carefully controlling their geometry, the elastic energy landscape of highly deformable systems can be engineered to propagate a variety of nonlinear waves including vector solitons, transition waves and rarefaction pulses. The dynamic behavior of such structures demonstrate a very rich physics, while offering new opportunities to manipulate the propagation of mechanical signals. Such mechanisms can allow unidirectional propagation, wave guiding, mechanical logic and mitigation, among other applications.

In this work, Deng et al. were inspired by the biological retrograde peristaltic wave motion in earthworms and the ability of linear elastic waves to generate motion in ultrasonic motors. The team showed the propagation of nonlinear elastic waves in flexible structures to provide opportunities for locomotion. As proof of concept, they focused on a Slinky – and used it to create a pulse-driven robot capable of propelling itself. They built the simple machine by connecting the Slinky to a pneumatic actuator. The team used an electromagnet and a plate embedded between the loops to initiate nonlinear pulses to propagate along the device from the front to the back, allowing the pulse directionality to dictate the simple robot to move forward. The results indicated the efficiency of such pulse-driven locomotion to be optimal with solitons – large amplitude nonlinear pulses with a constant velocity and stable shape along propagation.

Doctors at the Casey Eye Institute at Oregon Health & Science University in Portland have announced the first-ever use of the revolutionary gene editing tool, CRISPR, inside of a person’s body. The tool was used to modify the genes responsible for a particular form of inherited blindness, and those responsible for the pioneering effort say there is real potential here to not only restore the patient’s vision, but open up a new line of medicines specifically used to target and alter DNA.

In an Associated Press report, which comes via NBC, the companies that make the treatment used in the procedure, including Cambridge, Massachusetts-based Editas Medicine and Dublin-based Allergan, highlighted the possibilities moving forward if the trial proves to be successful. Charles Albright, chief scientific officer at Editas, said that “We literally have the potential to take people who are essentially blind and make them see.”

Continue reading “CRISPR Used Inside a Person’s Body for the First Time Ever” »

We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.