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Sugarcoated nanoparticles show promise for treating most aggressive form of brain cancer

Sugar-coated nanoparticles show promise against glioblastoma.

Researchers have developed mannose-coated lipid nanoparticles capable of crossing the blood-brain barrier and delivering therapeutic PTEN mRNA directly to glioblastoma cells, one of the deadliest forms of brain cancer.

Glioblastoma cells have an exceptionally high demand for glucose. By coating the nanoparticles with a sugar molecule called mannose, the researchers took advantage of this metabolic feature, allowing the particles to enter the brain more efficiently and accumulate within tumors.

Once inside the cancer cells, the nanoparticles restored production of PTEN, a critical tumor-suppressor protein that is frequently lost or dysfunctional in glioblastoma. In mouse models, this approach significantly slowed tumor growth, increased median survival by approximately 50%, and showed no measurable toxicity in major organs.

Although these findings are still preclinical and have not yet been tested in humans, they represent an exciting advance in overcoming one of neuro-oncology’s greatest challenges: safely delivering targeted therapies across the blood-brain barrier.


PORTLAND, Ore. – Researchers at Oregon State University have potentially found a new way to treat the most aggressive form of brain cancer, glioblastoma, whose two-year survival rate is less than 30%.

Scientists built a camera that can track invisible particles in 3D

Unlike an ordinary camera, which mainly records the intensity of incoming light, a light field camera also captures information about the direction from which the light arrived. This allows it to recover depth and reconstruct a scene in three dimensions.

The technology relies on a micro-lens array (MLA) placed between the camera’s main lens and imaging sensor. Each microscopic lens acts like a tiny camera, recording the same scene from a slightly different angle. When the information from all of these lenses is combined, the system can reconstruct a light field, which describes the intensity, position, and direction of the incoming light.

Tesla’s selling a $225 balance bike for toddlers

Tesla’s Autopilot may fail to recognize children at times, but the company certainly recognizes their potential as future buyers. The company just unveiled the $225 Balance Bike for Kids aimed at 2–5 year olds. Like the Radio Flyer Tesla Model Y, it lacks motors or even pedals and is simply designed to be pushed along by your kids’ feet, Flintstones style.

The bike comes with a lightweight white magnesium frame, five-way adjustable seat (in black), tools for assembly, “Tesla” word mark on the side and the T logo up front. The model is for tots under 77 pounds with legs less than 13-inches long. It’s at the top of the price range for balance bikes, with only a few models priced higher (like the Woom 1 which at least has brakes) and most under $100.

Tesla has made a few products for kids before, including the $1,900 Tesla Cyberquad ATV that was recalled for violating ATV safety standards for kids. Apparently, what Tesla fans really want is a branded e-bike, and they’d willing to pay extra to get one.

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