Lifeboat Foundation

Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.

In a new paper in Nano Letters, the researchers demonstrate how peptides — short strings of amino acids — can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons.

This represents an important advance in delivering mRNA to the cell types that would be key in treating neurodegenerative diseases; any such treatments will need to ensure that mRNA arrives at the correct location. Previous work by the same researchers proved that LNPs can cross the BBB and deliver mRNA to the brain, but did not attempt to control which cells the LNPs targeted.

Project Hyperion explores the feasibility of crewed interstellar travel via generation ships, using current and near-future technologies. A generation ship is a hypothetical spacecraft designed for long-duration interstellar travel, where the journey may take centuries to complete. The objective of the competition is to design the habitat of the generation ship, including its architecture and society.

Scientists achieve two-way communication in lucid dreams, unlocking new possibilities in therapy and skill learning.

CrystaLLM uses GPT to arrange atoms, turning text-based data into numerical tokens.

As the multi-polar world of global politics becomes ever more complex, who better to cast light on its workings than a physicist turned President? Join Armen Sarkissian, former President of Armenia, as he argues for his new theory of quantum politics, in which individuals are necessarily connected across space and our world is dominated by randomness, uncertainty, and possibility.

Tesla’s Megapack grid-scale storage systems have been selected for yet another solar energy and storage project, this time set to be installed in Chile.

Chilean energy storage developer Colbún has announced plans to install over 200 Tesla Megapacks as part of the 228 MW/912 MWh Celda Solar project in the northern part of the country, as detailed in a press release shared this week. The site will be constructed in the Camarones, Arica and Parinacota region, and the company estimates the total cost to be around $260 million.

“Energy storage will play an increasing role in the Chilean electricity system, allowing solar energy generated during the day to be accumulated and supplied to the system at night,” writes José Ignacio Escobar, Colbún CEO, as translated into English from Spanish. “Our energy stored in the reservoirs in the south complements perfectly with the energy that we will store in our batteries in the north, thus having a safe, diversified and competitive offer for our clients from Arica to Puerto Montt.”

Microsoft leads the AI GPU race, purchasing nearly 500k NVIDIA Hopper GPUs in 2024, while other tech giants also invest heavily in AI.

Scientists from the ALICE (A Large Ion Collider Experiment) at CERN’s Large Hadron Collider reported evidence of a new antimatter particle called antihyperhelium-4, essentially the “evil twin” of another weird particle called hyperhelium-4. This incredibly exotic form of matter contains two antiprotons, an antineutron, and an unstable particle called an antilambda comprised of subatomic quarks.

ASUS chairman Jonney Shih said the development of its first humanoid robot is already underway, wouldn’t be the first robot: ASUS has its Zenbo already.