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Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors

In the past decade, the therapeutic scope of sodium–glucose cotransporter 2 (SGLT2) inhibitors has expanded beyond glycaemic regulation in the management of type 2 diabetes mellitus. In this Review, Lim et al. discuss data from clinical studies of SGLT2 inhibitors, demonstrating their multifaceted cardiovascular, metabolic and renal effects, and elucidate the diverse mechanisms underpinning these benefits.

New rare genetic disease affecting motor neuron and muscle control identified

An international research team, led by Shinghua Ding at the University of Missouri, has identified a previously unknown genetic disease that affects movement and muscle control.

The disease—called Mutation in NAMPT Axonopathy (MINA) syndrome—causes damage to motor neurons, the that send signals from the brain and spinal cord to muscles. It’s the result of a rare genetic mutation in a known as NAMPT, which helps the body’s cells make and use energy. When this protein doesn’t work as it should, cells can’t produce enough energy to stay healthy.

Over time, this lack of energy causes the cells to weaken and die, and leads to symptoms such as muscle weakness, loss of coordination and foot deformities—which can worsen over time. In severe cases, patients may eventually need a wheelchair.

To fight cybercrime, student unravels the layers of 3D printing

To most people, a 3D printer is a cool piece of technology that can make toys, tools or parts in minutes. But for Hala Ali, it can be a partner in crime, and the doctoral student at Virginia Commonwealth University earned national honors recently for her work exploring one of the fastest-growing frontiers in cybercrime.

Ali, a computer science student in the College of Engineering, won best paper at this summer’s 25th annual Digital Forensics Research Conference in Chicago. The paper, “Leveraging Memory Forensics to Investigate and Detect Illegal 3D Printing Activities,” reflects her research into how digital forensics can help investigators uncover whether a 3D printer was used to create weapons or other illegal objects.

“3D printing is a process of creating a physical object from a by laying down successive layers of material until the object is created,” Ali said.

Lung cancer cells in the brain form electrical connections with neurons that spur tumor growth

By Krista Conger

Small cell lung cancer often metastasizes to the brain. A Stanford Medicine-led study shows the cancer cells form synapses with neurons, and signaling across these synapses encourages tumor growth.

The Holy Grail of Physics: Scientists Discover New Path to Room-Temperature Superconductors

Penn State scientists have unveiled a new theory-driven method to predict superconductors, offering a possible path toward materials that could conduct electricity perfectly. Electricity travels through wires to deliver power, but some of that energy is always lost along the way. However, that en

Weather radar data reveal alarming declines in insect populations

A research team including a Keele University scientist have made a breakthrough in monitoring insect populations across the UK using weather radar data. Traditionally used to track rainfall and storms, these radars are now helping researchers monitor the daily movements and long-term numbers of flying and floating creatures—including bees, moths, flies, spiders, and other arthropods.

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