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Training Mathematicians in the Age of AI: What Does It Mean to Become a Mathematician?

Artificial intelligence is changing not only how mathematics is done, but also how we determine whether someone truly understands mathematics. As AI systems become increasingly capable of generating proofs, discovering theorems, and producing polished academic writing, a fundamental question emerges: If AI can help produce original mathematical work, how can we tell whether a student has developed the expertise to understand and defend it? https://arxiv.org/abs/2609.

This paper argues that the purpose of graduate mathematics education must go beyond producing original theorems or impressive PhD dissertations. What matters just as much is developing intellectual agency—the ability to think independently, exercise mathematical judgment, understand why an argument works, and take responsibility for one’s own conclusions.

The author distinguishes between two ways of relying on AI. Productive cognitive offloading occurs when AI helps mathematicians handle routine or demanding tasks while strengthening their understanding and allowing them to focus on deeper problems. Premature cognitive offloading, by contrast, happens when students delegate essential intellectual work to AI before they have developed the skills needed to understand, evaluate, or independently reproduce the results. The danger is that students may appear highly productive while lacking the expertise their work is supposed to demonstrate.

To address this challenge, the paper proposes combining two approaches to mathematical training: independent work, which builds foundational skills and the ability to reason without AI, and AI-augmented work, which teaches students how to use these tools effectively and critically. It also calls for rethinking the PhD thesis and dissertation defense. Instead of evaluating students primarily on the originality and quality of their written output, universities should place greater emphasis on whether candidates genuinely understand their work, can explain their reasoning, recognize limitations, and respond intelligently to challenging questions.

Ultimately, the paper calls for a broader redefinition of the mission of academic mathematics. In an era when AI can increasingly contribute to mathematical discoveries, universities should not focus exclusively on producing more theorems and publications. They must also ensure that the next generation of mathematicians develops the knowledge, judgment, independence, and intellectual responsibility necessary to advance the discipline.

The central message is that producing mathematics and becoming a mathematician are not the same thing. Even as AI expands what people can accomplish, mathematical education must preserve the human capacity to understand, question, evaluate, and take responsibility for mathematical knowledge.

#ArtificialIntelligence #mathematics #CriticalThinking #TranformingEducation #HumanExpertise.

🧠🤖➗ JOIN US! | AI ERA MATH PhDs: Agency, Offloading, & the Thesis.

Lab-Grown Models Reveal How Anesthesia Alters Brain Activity

Assembloids help close that gap. Unlike neurons grown flat in a lab dish, which are among the models that have previously been used in these types of studies, the assembloids contain interconnected circuits that produce coordinated electrical activity. And unlike animal brains, they let researchers isolate and manipulate those circuits in a controlled human system.

Slow waves, quiet neurons

Created from induced pluripotent stem cells — adult cells that have been reprogrammed into a stem cell-like state — the assembloids combine three types of brain cells: excitatory neurons, which transmit signals; inhibitory neurons, which restrain activity; and glial cells, which play multiple roles in brain function. Together, these cells form circuits capable of generating coordinated rhythms similar to those in the human brain.

Non-invasive nanoparticle barcoding in nonhuman primates

et al. developed a clever DNA barcode system to measure pooled lipid nanoparticle (LNP) delivery in nonhuman primates by taking small samples of serum. This allows high-throughput NHP screening of the efficacy of LNP formulations without killing monkeys. However, a limitation of the technique is that the readout does not encode which tissues the LNPs reach. Nonetheless, I expect this method will accelerate LNP discovery while minimizing harm to NHP animals.


Simultaneous delivery of several lipid nanoparticles is quantified using snapCodes in a single nonhuman primate.

Targeting mRNA therapeutics: current approaches and emerging platforms

A good review paper covering current and emerging approaches for modifying lipid nanoparticles (LNPs) towards better tissue-specific targeting.


MRNA therapeutics is a rapidly expanding area of research within various medical applications, ranging from vaccines to cancer treatments. First widely adopted into the mainstream as a prevention tool for avoiding severe illness from SARS Cov2, mRNA is now being explored as a way to address genetic disorders and various forms of cancer. By encoding CRISPR machinery to be translated into cells or by training the immune system to attack cancerous cells, mRNA is fast becoming a powerful treatment tool for gaining access to traditionally undruggable targets. As the formulation chemistries that enable mRNA to be effective at expressing therapeutic proteins race forward, there are two major challenges currently limiting its full clinical potential. The first is the generalized inability to effectively target mRNA to specific cell types using standard LNPs, and the second, even more limiting challenge, is mRNA’s inability to efficiently reach the cytosol of cells once targeted to a specific cell type. Here, we will review aspects of the first challenge with regard to current methods of targeting mRNA, introducing new emerging platforms that seek to incorporate antibodies, aptamers, and small molecules as targeting agents. We highlight ways in which these critical challenges are being addressed and what future formulation designs seek to enable in order to achieve a more controlled delivery of this important biomolecule.

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The big reveal: Chinese firm cuts open its robot to prove it’s not human

Xpeng’s humanoid robot “Iron” will enter mass production later this year, with deliveries starting as early as the first quarter of next year. 2027 will mark the beginning of the era of humanoid robots.

1. The Robot: XPeng “IRON”

- Physical Specs: IRON is a high-end general-purpose humanoid robot standing about 1.73 meters tall and weighing approximately 70 kg.

- Capabilities: It features 200 degrees of freedom (DoF) for highly fluid motion, including 22-DoF dexterous hands, and 720° panoramic vision.

- AI Compute: The robot is powered by three of XPeng’s self-developed “Turing” AI chips, delivering an effective compute power of up to 2,250 TOPS, enabling advanced “Physical AI” and embodied intelligence.

2. Mass Production Timeline (Late 2026)

- Production Line Live: On September 8, 2026, XPeng officially commissioned its automated humanoid robot production line in Guangzhou, China.

- First Unit: The very first IRON robot successfully completed automated assembly and autonomously walked off the production line, marking a major milestone toward scale manufacturing.

Moderna stock hits 4-year high on planned national cancer vaccine effort

Moderna (MRNA) stock popped 14% on Friday, reaching its highest level since January 2022, after the New York Times reported new details about an effort to accelerate cancer vaccine development. Investors saw the mRNA biotech company, in particular, as a beneficiary.

Biotech stocks, including Pfizer (PFE), BioNTech (BNTX), and Merck (MRK), rallied on the news. Novavax (NVAX) shares surged 15%.

Tryptophan Absorption Declines During Aging: Can It Be Improved?

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